scholarly journals A Biomedical Knowledge Graph System to Propose Mechanistic Hypotheses for Real-world Environmental Health Observations: Application (Preprint)

2020 ◽  
Author(s):  
Karamarie Fecho ◽  
Chris Bizon ◽  
Frederick Miller ◽  
Shepherd Schurman ◽  
Charles Schmitt ◽  
...  
Keyword(s):  
User Interface ◽  
Environmental Health ◽  
Survey Data ◽  
Real World ◽  
Knowledge Graph ◽  
Supporting Evidence ◽  
Biomedical Knowledge ◽  
Environmental Health Sciences ◽  
Immune Mediated ◽  
Answer Sets

BACKGROUND Knowledge graphs are a common form of knowledge representation in biomedicine and many other fields. We developed an open biomedical knowledge graph–based system termed Reasoning Over Biomedical Objects linked in Knowledge Oriented Pathways, or ROBOKOP. ROBOKOP consists of both a front-end user interface and a back-end knowledge graph. The ROBOKOP user interface allows users to posit questions and explore answer subgraphs. Users can also posit questions through direct Cypher query of the underlying knowledge graph, which currently contains roughly 6M nodes or biomedical entities and 140M edges or predicates describing the relationship between nodes, drawn from >30 curated data sources. OBJECTIVE We aimed to apply ROBOKOP to survey data on workplace exposures and immune-medicated diseases from the Environmental Polymorphisms Registry (EPR) within the National Institute of Environmental Health Sciences. METHODS We analyzed EPR survey data focused on immune-mediated diseases and identified 45 associations between chemical workplace exposures and immune-mediated diseases, as self-reported by study participants (N = 4574), with 20 associations significant at P < .05 after a false discovery rate connection. We then used ROBOKOP to: (1) validate the associations by determining whether plausible connections exist within the ROBOKOP knowledge graph; and (2) propose biological mechanisms that might explain them and serve as hypotheses for subsequent testing. We highlight three exemplar associations: carbon monoxide – multiple sclerosis; ammonia – asthma; and isopropanol – allergic disease. RESULTS ROBOKOP successfully returned answer sets for three queries that were posed in the context of the driving examples. The answer sets included potential intermediary genes, as well as supporting evidence that might explain the observed associations. CONCLUSIONS We demonstrate a real-world application of ROBOKOP to generate mechanistic hypotheses for associations between chemical workplace exposure and immune-mediates diseases. We expect that ROBOKOP will find broad application across many biomedical fields and other scientific disciplines due to its generalizability, speed to discovery and generation of mechanistic hypotheses, and open nature.

scholarly journals A Biomedical Knowledge Graph System to Propose Mechanistic Hypotheses for Real-world Environmental Health Observations: Application (Preprint)

10.2196/26714 ◽  
2020 ◽  
Author(s):  
Karamarie Fecho ◽  
Chris Bizon ◽  
Frederick Miller ◽  
Shepherd Schurman ◽  
Charles Schmitt ◽  
...  
Keyword(s):  
Environmental Health ◽  
Real World ◽  
Knowledge Graph ◽  
Biomedical Knowledge ◽  
Graph System

Exploring the Real World: Medical Librarians' Involvement in Supporting Evidence-Based Medicine (EBM) Practice

2013 ◽  
Author(s):  
Ping Li ◽  
Lin Wu
Keyword(s):  
Data Analysis ◽  
Survey Data ◽  
Real World ◽  
Evidence Based Medicine ◽  
Online Survey ◽  
Evidence Based ◽  
Supporting Evidence ◽  
The Real ◽  
Based Medicine

This paper reports the results of an online survey that explores medical librarians’ roles and activities in supporting EBM practice. More than 500 medical librarians replied to the survey. Data analysis reveals that librarians have been taking on various EBM-related responsibilities both routine by nature and project-related.Cet article présente les résultats d’un sondage en ligne portant sur les rôles et les activités des bibliothécaires du domaine des sciences de la santé pour soutenir les pratiques de médecine fondée sur les preuves (MFP). Plus de 500 bibliothécaires ont répondu au sondage. L’analyse des données révèlent que ces bibliothécaires ont participé à des activités routinières et à des projets relevant du domaine de la MFP. 

scholarly journals Catalyzing Knowledge-Driven Discovery in Environmental Health Sciences through a Community-Driven Harmonized Language

2021 ◽  
Vol 18 (17) ◽  
pp. 8985
Author(s):  
Stephanie D. Holmgren ◽  
Rebecca R. Boyles ◽  
Ryan D. Cronk ◽  
Christopher G. Duncan ◽  
Richard K. Kwok ◽  
...  
Keyword(s):  
Environmental Health ◽  
Large Scale ◽  
Health Sciences ◽  
Knowledge Bases ◽  
Scientific Data ◽  
Biomedical Knowledge ◽  
Environmental Health Sciences ◽  
Community Initiative ◽  
Meta Analyses ◽  
Standard Terms

Harmonized language is critical for helping researchers to find data, collecting scientific data to facilitate comparison, and performing pooled and meta-analyses. Using standard terms to link data to knowledge systems facilitates knowledge-driven analysis, allows for the use of biomedical knowledge bases for scientific interpretation and hypothesis generation, and increasingly supports artificial intelligence (AI) and machine learning. Due to the breadth of environmental health sciences (EHS) research and the continuous evolution in scientific methods, the gaps in standard terminologies, vocabularies, ontologies, and related tools hamper the capabilities to address large-scale, complex EHS research questions that require the integration of disparate data and knowledge sources. The results of prior workshops to advance a harmonized environmental health language demonstrate that future efforts should be sustained and grounded in scientific need. We describe a community initiative whose mission was to advance integrative environmental health sciences research via the development and adoption of a harmonized language. The products, outcomes, and recommendations developed and endorsed by this community are expected to enhance data collection and management efforts for NIEHS and the EHS community, making data more findable and interoperable. This initiative will provide a community of practice space to exchange information and expertise, be a coordination hub for identifying and prioritizing activities, and a collaboration platform for the development and adoption of semantic solutions. We encourage anyone interested in advancing this mission to engage in this community.

scholarly journals Real-World Evidence of Caplacizumab Use in the Management of Acute TTP

Blood ◽  
2020 ◽  
Author(s):  
Tina Dutt ◽  
Rebecca J Shaw ◽  
Matthew James Stubbs ◽  
Jun Yong ◽  
Benjamin Bailiff ◽  
...  
Keyword(s):  
Platelet Count ◽  
Real World ◽  
Patient Characteristics ◽  
Patient Access Scheme ◽  
Fda Approval ◽  
Immune Mediated ◽  
Real World Evidence ◽  
Life Saving ◽  
The Uk ◽  
Von Willebrand

The cornerstone of life-saving therapy in immune mediated thrombotic thrombocytopenic purpura (iTTP) has been plasma exchange (PEX) combined with immunomodulatory strategies. Caplacizumab, a novel anti-von Willebrand factor nanobody, trialled in two multicentre, randomised-placebo-controlled trials leading to EU and FDA approval, has been available in the UK through a patient-access scheme. Data was collected retrospectively from 2018-2020 for 85 patients receiving caplacizumab, including 4 children, from 22 UK hospitals. Patient characteristics and outcomes in the real-world clinical setting were compared with caplacizumab trial endpoints and historical outcomes in the pre-caplacizumab era. 84/85 patients received steroid and rituximab alongside PEX; 26% required intubation. Median time to platelet count normalisation (3 days), duration of PEX (7 days) and hospital stay (12 days) was comparable with RCT data. Median duration of PEX and time from PEX initiation to platelet count normalisation was favourable compared with historical outcomes (p&lt;0.05). TTP recurrence occurred in 5/85 patients; all with persistent ADAMTS13 activity &lt;5iu/dL. Of 31 adverse events in 26 patients, 17/31 (55%) were bleeding episodes and 5/31 (16%) were thrombotic events (two unrelated to caplacizumab); mortality was 6% (5/85), with no deaths attributed to caplacizumab. In 4/5 deaths caplacizumab was introduced &gt;48 hours after PEX initiation (3-21 days). This real-world evidence represents the first and largest series of TTP patients receiving caplacizumab outside clinical trials, including paediatric patients. Representative of true clinical practice, the findings provide valuable information for clinicians treating TTP globally.

A Lightweight User Interface for Smart Charging of Electric Vehicles: A Real-World Application

2021 ◽  
Author(s):  
Stefan Meisenbacher ◽  
Karl Schwenk ◽  
Johannes Galenzowski ◽  
Simon Waczowicz ◽  
Ralf Mikut ◽  
...  
Keyword(s):  
User Interface ◽  
Electric Vehicles ◽  
Real World ◽  
Real World Application ◽  
Smart Charging

scholarly journals #ODU2ODU: Testing the Benefits of a Partnership Between Sport Management Classrooms

2020 ◽  
Vol 1 ◽  
pp. 18-35
Author(s):  
Brendan O'Hallarn ◽  
James Strode
Keyword(s):  
Social Media ◽  
Survey Data ◽  
Real World ◽  
Sport Management ◽  
Media Use ◽  
Academic Research ◽  
Perceived Benefits ◽  
Media Technologies ◽  
Social Media Site ◽  
The Social

As sport management pedagogy has evolved, an effort has been made to incorporate popular and innovative social media technologies into classroom instruction. Academic research has suggested how the technology can be utilized to provide real-world skills for students and develop proficiencies in an area where many sport management graduates find employment. Notable among the recommendations about social media use by sport management scholars is a lack of research testing the efficacy of these tools in improving curricula. The current study relied on the recommendations of Sanderson and Browning (2015) to use the social media site Twitter to create online partnerships, testing the perceived benefits of such an arrangement through end-of-semester surveys with student participants. While the survey data show a true partnership may be difficult to realize—particularly during a single semester—the benefits of such an assignment were clearly articulated.

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