scholarly journals Hybrid Multimedia / In-Person Intervention Addressing Cerebrovascular Health Needs among Minority Populations at Risk of Urban Flooding (Preprint)

Author(s):  
Elizabeth A Noser ◽  
Jing Zhang ◽  
Mohammad H Rahbar ◽  
Anjail Z Sharrief ◽  
Andrew D Barreto ◽  
...  
2021 ◽  
Author(s):  
Elizabeth A Noser ◽  
Jing Zhang ◽  
Mohammad H Rahbar ◽  
Anjail Z Sharrief ◽  
Andrew D Barreto ◽  
...  

BACKGROUND Social inequities affecting minority populations after Hurricane Katrina led to an expansion of environmental justice literature. In August 2017, Hurricane Harvey rainfall was estimated as a 3,000 to 20,000 year event. To address dual concerns of urban flooding and disproportionate stroke prevalence among minorities, Stomp out Stroke, a patient-centered community outreach intervention, focused on improving knowledge of race/ethnicity specific healthcare needs. OBJECTIVE Our study addressed social inequities in minority cerebrovascular health through (1) the identification of race/ethnicity specific healthcare needs and (2) the provision of structured stroke prevention screening during two annual community engagement events (May 2018 and May 2019). METHODS Stomp out Stroke registrant surveys (age>18 years) detailed sociodemographic characteristics, family history of stroke and stroke survivorship. Participant healthcare interests’ were assessed. Comparisons by race/ethnicity [Asian, African-American(AA), Hispanic or non-Hispanic White (NHW)] were conducted using Kruskal-Wallis or Chi-square test. P < 0.05 equaled a statistically significant difference between >2 groups. RESULTS A total of 1401 people registered for Stomp out Stroke. Registrants were 70% female, median age 45 years. Participants largely self-identified as members of minority groups - 32% Hispanic, 26% AA, 14% Asian compared to 24%NHW. Stroke survivors comprised 11% of our population (n=155), 124 stroke caregivers participated. Approximately 37% of participants had a family history of stroke (n=493). AAs were most likely to have Medicare/Medicaid insurance (24.6%); Hispanics were most likely to be uninsured (29.2%). Hispanics were more likely than NHW to obtain health screenings (62.8 vs 52.9%; P=0.03). Asian and AAs were more likely to request stroke education than NHWs or Hispanics (55 or 56% vs 41.7 or 43%). AAs were more likely to seek overall health education than NHWs (46.2 vs 32.65%; P<0.01). NHWs were less likely than AAs or Asians to speak to healthcare providers (14.5 vs 25.3 or 28.3%). During the 2018 and 2019 events, 2774 Health Screenings were completed. These screenings included Blood Pressure (n=1031, 37.2%), Stroke Risk Assessment (n=496, 17.9%), Bone Density (n=426, 15.4%), Carotid Ultrasound (n=380, 13.7%) , Body Mass Index (n=182, 6.5%), Serum Lipids (n=157, 5.6%) and Hemoglobin A1C (n=102, 3.7%). CONCLUSIONS Stomp out Stroke identified race/ethnicity specific healthcare needs and provided appropriate screenings to minority populations at increased risk of urban flooding and stroke. This community engagement protocol can be replicated in Southern US “Stroke Belt” cities (New Orleans LA, Charleston SC, Savannah GA) with similar flood risk.


2021 ◽  
Vol 35 (2) ◽  
pp. 301-311 ◽  
Author(s):  
Mark É. Czeisler ◽  
Mark E. Howard ◽  
Shantha M. W. Rajaratnam

Author(s):  
Andrew J. Paul ◽  
Christopher L. Cahill ◽  
Laura MacPherson ◽  
Michael G. Sullivan ◽  
Myles R. Brown

1980 ◽  
Vol 73 (1) ◽  
pp. 25-27 ◽  
Author(s):  
GEORGE A. NORTON ◽  
RAYMOND W. POSTLETHWAIT ◽  
WILLIAM M. THOMPSON

Critical Care ◽  
2019 ◽  
Vol 23 (1) ◽  
Author(s):  
Juan Gonzalez del Castillo ◽  
◽  
Darius Cameron Wilson ◽  
Carlota Clemente-Callejo ◽  
Francisco Román ◽  
...  

Abstract Background The performance of blood biomarkers (mid-regional proadrenomedullin (MR-proADM), procalcitonin (PCT), C-reactive protein (CRP), and lactate) and clinical scores (Sequential Organ Failure Assessment (SOFA), National Early Warning Score (NEWS), and quick SOFA) was compared to identify patient populations at risk of delayed treatment initiation and disease progression after presenting to the emergency department (ED) with a suspected infection. Methods A prospective observational study across three EDs. Biomarker and clinical score values were calculated upon presentation and 72 h, and logistic and Cox regression used to assess the strength of association. Primary outcomes comprised of 28-day mortality prediction and delayed antibiotic administration or intensive care (ICU) admission, whilst secondary outcomes identified subsequent disease progression. Results Six hundred eighty-four patients were enrolled with hospitalisation, ICU admission, and infection-related 28-day mortality rates of 72.8%, 3.4%, and 4.4%, respectively. MR-proADM and NEWS had the strongest association with hospitalisation and the requirement for antibiotic administration, whereas MR-proADM alone had the strongest association with ICU admission (OR [95% CI]: 5.8 [3.1 - 10.8]) and mortality (HR [95% CI]: 3.8 [2.2 - 6.5]). Patient subgroups with high MR-proADM concentrations (≥ 1.77 nmol/L) and low NEWS (< 5 points) values had significantly higher rates of ICU admission (8.1% vs 1.6%; p < 0.001), hospital readmission (18.9% vs. 5.9%; p < 0.001), infection-related mortality (13.5% vs. 0.2%; p < 0.001), and disease progression (29.7% vs. 4.9%; p < 0.001) than corresponding patients with low MR-proADM concentrations. ICU admission was delayed by 1.5 [0.25 – 5.0] days in patients with high MR-proADM and low NEWS values compared to corresponding patients with high NEWS values, despite similar 28-day mortality rates (13.5% vs. 16.5%). Antibiotics were withheld in 17.4% of patients with high MR-proADM and low NEWS values, with higher subsequent rates of ICU admission (27.3% vs. 4.8%) and infection-related hospital readmission (54.5% vs. 14.3%) compared to those administered antibiotics during ED treatment. Conclusions Patients with low severity signs of infection but high MR-proADM concentrations had an increased likelihood of subsequent disease progression, delayed antibiotic administration or ICU admission. Appropriate triage decisions and the rapid use of antibiotics in patients with high MR-proADM concentrations may constitute initial steps in escalating or intensifying early treatment strategies.


2010 ◽  
Vol 27 (5) ◽  
pp. 418-424 ◽  
Author(s):  
Hayley Mark ◽  
Susan G. Sherman ◽  
Joy Nanda ◽  
Tracey Chambers-Thomas ◽  
Mathilda Barnes ◽  
...  

2018 ◽  
Vol 3 (1) ◽  
pp. 89-99 ◽  
Author(s):  
Robert H Christenson ◽  
Marvin Lessig ◽  
Gabrielle Miles ◽  
Silke Luebcke ◽  
Cheryl Stillions ◽  
...  

Abstract Background The Elecsys® syphilis immunoassay is an automated, qualitative immunoassay that uses a double-antigen sandwich format to detect antibodies to Treponema pallidum in human serum and plasma. We aimed to validate performance of the immunoassay in various populations at risk for syphilis infection in the US and Argentina. Methods Samples were obtained for a number of study cohorts, including participants from routine syphilis testing at high or low risk for syphilis, HIV-positive patients, pregnant women, and patients in various stages of syphilis infection. The primary objective was to validate the Elecsys syphilis immunoassay by comparing it with a composite testing algorithm using US Food and Drug Administration (FDA)-approved tests, including the predicate IMMULITE 2000 syphilis screening assay, the rapid plasma reagin, and the T. pallidum particle agglutination assay. Results Complete algorithm testing was performed on all 2660 collected samples. Acceptable precision was demonstrated in all samples. Comparison of the Elecsys syphilis immunoassay with the final syphilis status for all samples yielded a diagnostic sensitivity of 99.5% (95% CI, 98.21–99.94) and a diagnostic specificity of 99.2% (95% CI, 98.69–99.49). Overall, the lower limit of the 95% CIs for sensitivity and specificity met the expected performance of ≥95%. Conclusion This is the first study that confirms the high sensitivity and specificity of the Elecsys syphilis immunoassay in US and Argentinian cohorts and highlights the assay's usefulness as an alternative to current tests for the diagnosis of syphilis infection in a broad range of participant cohorts.


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