scholarly journals Prevalence of Allergic Diseases in Patients with Common Autoinflammatory Diseases

2021 ◽  
Vol 19 (1) ◽  
pp. 32-37
Author(s):  
Tuba Erdoğan ◽  
Nazife Şule yaşar Bilge ◽  
Timuçin Kaşifoğlu
Keyword(s):  
Allergic Rhinitis ◽  
Familial Mediterranean Fever ◽  
Behçet’S Disease ◽  
Behcet’S Disease ◽  
Behçet's Disease ◽  
Allergic Diseases ◽  
Innate Immune ◽  
Autoinflammatory Diseases ◽  
Behcet's Disease ◽  
Mediterranean Fever

ABSTRACT Objective: Autoinflammatory diseases are driven by abnormal activation of the innate immune system. Although allergic diseases are known to be mediated by the T helper 2 response, new mechanisms are put forward about the activation of innate immunity during exposure to allergens in recent years. Familial Mediterranean fever (FMF) and Behçet’s disease (BD) are the commonly seen autoinflammatory diseases in Turkey. It was aimed to determine the prevalence of allergic diseases in BD and FMF and contribute to explaining the relationship between autoinflammation and allergic diseases in this survey. Materials and Methods: The study included 42 patients with BD, 40 with FMF, 20 with other rheumatic diseases, and 20 healthy controls who had volunteered for allergic evaluation. Patients were questioned about allergic diseases such as asthma, allergic rhinitis, atopic dermatitis, venom allergy, and food-drug allergy. The same prick test panel was used for all patients to investigate the presence of atopy. Results: Although the rate of allergic diseases and the blood eosinophil rate were significantly higher in patients with FMF and Behçet’s disease, which are commonly seen as autoinflammatory diseases, atopy rates were similar in all groups. The prevalence of allergic rhinitis and any allergic diseases was significantly higher in the FMF and BD groups (p: 0.03 and p: 0.02, respectively). In the multiple logistic regression model of the presence of any allergic disease, none of the factors was associated with allergic diseases. Conclusion: The prevalence of allergic diseases in patients with FMF and BD was found to be higher than in those with other rheumatic diseases and the control group but atopy rates were similar in all groups. The autoinflammatory diseases are not protective in terms of allergic sensitization and allergic rhinitis. This may be the result of recent advances in the innate immune sensing system. Keywords: Allergic diseases, autoinflammatory diseases, familial Mediterranean fever, Behçet’s disease, atopy

scholarly journals Coexistence of Familial Mediterranean Fever and Behçet's Disease in a Japanese Patient

2006 ◽  
Vol 45 (12) ◽  
pp. 799-800 ◽  
Author(s):  
Masayuki Matsuda ◽  
Akinori Nakamura ◽  
Saiko Tsuchiya ◽  
Takuhiro Yoshida ◽  
Shiro Horie ◽  
...  
Keyword(s):  
Familial Mediterranean Fever ◽  
Behçet’S Disease ◽  
Japanese Patient ◽  
Behcet’S Disease ◽  
Behçet's Disease ◽  
Behcet's Disease ◽  
Mediterranean Fever

Sonographic evaluation of the tendons in familial Mediterranean fever and Behçet’s disease

2006 ◽  
Vol 73 (5) ◽  
pp. 514-517 ◽  
Author(s):  
Levent Özçakar ◽  
Ahmet Mesut Onat ◽  
Kemal Üreten ◽  
Alp Çetin ◽  
Sedat Kiraz ◽  
...  
Keyword(s):  
Familial Mediterranean Fever ◽  
Behçet’S Disease ◽  
Behcet’S Disease ◽  
Behçet's Disease ◽  
Behcet's Disease ◽  
Sonographic Evaluation ◽  
Mediterranean Fever

scholarly journals Coexistence of Behçet’s disease with ankylosing spondylitis and familial Mediterranean fever: a rare occurrence

2011 ◽  
Vol 1 (2) ◽  
pp. 34 ◽  
Author(s):  
Makram Frigui ◽  
Manel Kechaou ◽  
Moez Jallouli ◽  
Neila Kaddour ◽  
Habiba Bouhamed Chaabouni ◽  
...  
Keyword(s):  
Ankylosing Spondylitis ◽  
Familial Mediterranean Fever ◽  
Behçet’S Disease ◽  
Behcet’S Disease ◽  
Behçet's Disease ◽  
Human Leukocyte ◽  
Distribution Patterns ◽  
Joint Involvement ◽  
Behcet's Disease ◽  
Mediterranean Fever

Behçet's disease (BD) and familial Mediterranean fever (FMF), which are two separate diseases sharing some clinical features, may also coexist in the same patient. Further investigations are needed to understand whether this coexistence is due to either chance or geographical distribution patterns of these diseases or to common etiopathogenetic characteristics. Spondylarthritis as part of the clinical picture in these two diseases has been questioned and probably it is not a prominent characteristic of any of them. We report a 35- year-old Tunisian man who had an association of BD, FMF and Human Leukocyte Antigen (HLA) B27 positive ankylosing spondylitis. Although that spondylarthritis is an infrequent joint involvement of FMF and BD, it must be looked for in case of association of these diseases.

scholarly journals SIMILARITIES AND DIFFERENCES BETWEEN FAMILIAL MEDITERRANEAN FEVER AND BEHÇET’S DISEASE

2021 ◽  
Vol 2 (1) ◽  
pp. 43-50
Author(s):  
Ummusen Kaya Akca ◽  
Ezgi Deniz Batu
Keyword(s):  
Familial Mediterranean Fever ◽  
Behçet’S Disease ◽  
Behcet’S Disease ◽  
Behçet's Disease ◽  
Mefv Gene ◽  
Common Symptom ◽  
Behcet's Disease ◽  
Mediterranean Fever ◽  
Similarities And Differences ◽  
The Mediterranean

Familial Mediterranean Fever (FMF) is the most common monogenic autoinflammatory disease, mainly affecting populations originating from the Eastern Mediterranean region. Behçet’s Disease (BD) is grouped in polygenic autoinflammatory diseases. It is a systemic vasculitis that affects all types and sizes of blood vessels. The aim of this article is to shed light on similarities and differences between FMF and BD. BD is frequently reported along the ancient Silk Road, extending from the Far East to the Mediterranean basin. Several studies have searched for the association between FMF and BD. FMF is caused by mutations of the MEditerranean FeVer (MEFV) gene while an increased frequency of MEFV mutations is reported in BD patients. Although BD and FMF share some epidemiological and pathophysiological features, there are distinct clinical characteristics of these nosological entities. Mucocutaneous manifestations, especially recurrent oral ulcers, are the most common symptom in BD patients whereas fever accompanied by serosal inflammation is the main clinical presentation in FMF patients.

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