scholarly journals Coexistence of Behçet’s disease with ankylosing spondylitis and familial Mediterranean fever: a rare occurrence

2011 ◽  
Vol 1 (2) ◽  
pp. 34 ◽  
Author(s):  
Makram Frigui ◽  
Manel Kechaou ◽  
Moez Jallouli ◽  
Neila Kaddour ◽  
Habiba Bouhamed Chaabouni ◽  
...  

Behçet's disease (BD) and familial Mediterranean fever (FMF), which are two separate diseases sharing some clinical features, may also coexist in the same patient. Further investigations are needed to understand whether this coexistence is due to either chance or geographical distribution patterns of these diseases or to common etiopathogenetic characteristics. Spondylarthritis as part of the clinical picture in these two diseases has been questioned and probably it is not a prominent characteristic of any of them. We report a 35- year-old Tunisian man who had an association of BD, FMF and Human Leukocyte Antigen (HLA) B27 positive ankylosing spondylitis. Although that spondylarthritis is an infrequent joint involvement of FMF and BD, it must be looked for in case of association of these diseases.

2006 ◽  
Vol 45 (12) ◽  
pp. 799-800 ◽  
Author(s):  
Masayuki Matsuda ◽  
Akinori Nakamura ◽  
Saiko Tsuchiya ◽  
Takuhiro Yoshida ◽  
Shiro Horie ◽  
...  

2006 ◽  
Vol 73 (5) ◽  
pp. 514-517 ◽  
Author(s):  
Levent Özçakar ◽  
Ahmet Mesut Onat ◽  
Kemal Üreten ◽  
Alp Çetin ◽  
Sedat Kiraz ◽  
...  

2021 ◽  
Vol 2 (1) ◽  
pp. 43-50
Author(s):  
Ummusen Kaya Akca ◽  
Ezgi Deniz Batu

Familial Mediterranean Fever (FMF) is the most common monogenic autoinflammatory disease, mainly affecting populations originating from the Eastern Mediterranean region. Behçet’s Disease (BD) is grouped in polygenic autoinflammatory diseases. It is a systemic vasculitis that affects all types and sizes of blood vessels. The aim of this article is to shed light on similarities and differences between FMF and BD. BD is frequently reported along the ancient Silk Road, extending from the Far East to the Mediterranean basin. Several studies have searched for the association between FMF and BD. FMF is caused by mutations of the MEditerranean FeVer (MEFV) gene while an increased frequency of MEFV mutations is reported in BD patients. Although BD and FMF share some epidemiological and pathophysiological features, there are distinct clinical characteristics of these nosological entities. Mucocutaneous manifestations, especially recurrent oral ulcers, are the most common symptom in BD patients whereas fever accompanied by serosal inflammation is the main clinical presentation in FMF patients.


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