Nondysplastic Crypts in Fission in Nonpolypoid Adenomas and in the Adjacent Mucosa Support Field Cancerization in the Colon

CARLOS A. RUBIO; PETER T. SCHMIDT

doi:10.21873/anticanres.14910

Field Cancerization in Oral Cavity: A review

Journal of Clinical Case Studies Reviews & Reports ◽

10.47363/jccsr/2020(2)127 ◽

2020 ◽

Vol 2 (3) ◽

pp. 1-5

Author(s):

Adel Bouguezz ◽

◽

Sameh Sioud ◽

Hajer Hentati ◽

◽

...

Keyword(s):

Field Cancerization ◽

Upper Aerodigestive Tract ◽

Epithelial Surface ◽

Adjacent Mucosa ◽

Independent Events ◽

Increased Risk ◽

Genetic Abnormalities ◽

Tissue Region ◽

Malignant Lesions ◽

Almost All

Patients with head and neck squamous cell carcinoma (HNSCC) often develop multiple (pre) malignant lesions. This finding led to the field of the cancerization theory, which hypothesizes that the entire epithelial surface of the upper aerodigestive tract has an increased risk for the development of (pre) malignant lesions, because of multiple genetic abnormalities in the whole tissue region. Demonstration of alterations in histologically normal tumor-adjacent mucosa from HNSCC patients supported this hypothesis. Currently, the question has been raised whether multiple lesions develop independently from each other or from migrated malignant or progenitor cells. Moreover, almost all primary remote tumors from HNSCC patients appear to be clonally unrelated. Therefore, there is more evidence that field cancerization is due to multiple independent events than to migration of genetically altered cells.

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Genotypic abnormalities in tumor-adjacent mucosa supports the field cancerization theory

Advances in Anatomic Pathology ◽

10.1097/00125480-199703000-00019 ◽

1997 ◽

Vol 4 (2) ◽

pp. 117

Author(s):

&NA;

Keyword(s):

Field Cancerization ◽

Adjacent Mucosa

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P53 overexpression in epidermoid carcinoma of the head and neck

Sao Paulo Medical Journal ◽

10.1590/s1516-31801997000100006 ◽

1997 ◽

Vol 115 (1) ◽

pp. 1349-1355 ◽

Cited By ~ 3

Author(s):

Angela Flavia Logullo ◽

Luiz Paulo Kowalski ◽

Sueli Nonogaki ◽

Roberto E. V. Miguel ◽

Humberto Torloni ◽

...

Keyword(s):

Head And Neck ◽

P53 Protein ◽

Demographic Data ◽

Control Cell ◽

Genetic Alterations ◽

Field Cancerization ◽

P53 Overexpression ◽

P53 Expression ◽

Adjacent Mucosa ◽

Normal Adjacent Mucosa

The theory of field cancerization in tumors of the head and neck reflects the complex oncogenesis that occurs in this region. The mechanisms that control cell proliferation at the molecular level in epidermoid carcinomas (ECs) of the upper aerodigestive tract are still unclear. Mutations in p53 are the genetic alterations most often detected in ECs of the head and neck and seem to contribute actively to the carcinogenic process triggered by p53 as a tumor-suppressor gene and to its association with tobacco. The objective of the present study was to investigate the expression of p53 protein in epidermoid head and neck carcinomas by immunohistochemistry and its immunohistochemical correlation with other prognostic factors. The study was conducted on 63 consecutive ECs cases not submitted to previous treatment. Specimens of the tumor and of the normal adjacent mucosa were collected during surgery and submitted to immunohistochemical reaction for the determination of the expression of anti-protein p53 antibody (M7001 DAKO A/S, Denmark). Anatomo-clinical and demographic data were not significantly correlated with the presence of lymph node metastases or p53 expression in the tumor or in the adjacent normal mucosa. Tumor localization in the larynx was significantly correlated with p53 expression. Histological grading as grades I, II, Ill and IV was correlated with significant p53 expression (p = 0.025). Conclusions: 1) in the studied material obtained from 63 cases of head and neck ECs, we detected a 48 percent rate of immunohistochemically detectable p53 overexpression; 2) we did not detect a relationship between demographic patient data and p53 expression in the tumor or in the normal adjacent mucosa; 3) p53 overexpression was significantly more frequent in ECs material from the larynx; and 4) The presence of 12 cases with p53 overexpression in the normal adjacent mucosa and with a p53-negative tumor is in agreement with the theory of field cancerization. Follow-up of this patient series for a longer period of time will permit a better analysis of these values.

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