The Effect of Alcohol, Cigarette Smoking and Their Cessation for Risk of Field Cancerization of Esophagus and Head and Neck

2020 ◽  
Author(s):  
Manabu Muto ◽  
Chikatoshi Katada ◽  
Tetsuji Yokoyama ◽  
Tomonori Yano ◽  
Ichiro Oda ◽  
...  
Keyword(s):  
Cigarette Smoking ◽  
Head And Neck ◽  
Field Cancerization

scholarly journals Cancer stem cells and field cancerization of head and neck cancer - An update

2020 ◽  
Vol 9 (7) ◽  
pp. 3178
Author(s):  
Richa Bansal ◽  
BikashBishwadarshee Nayak ◽  
Shweta Bhardwaj ◽  
CN Vanajakshi ◽  
Pragyan Das ◽  
...  
Keyword(s):  
Stem Cells ◽  
Head And Neck Cancer ◽  
Cancer Stem Cells ◽  
Head And Neck ◽  
Neck Cancer ◽  
Field Cancerization

scholarly journals Curcumin and Other Polyphenolic Compounds in Head and Neck Cancer Chemoprevention

2012 ◽  
Vol 2012 ◽  
pp. 1-9 ◽  
Author(s):  
Philipp Baumeister ◽  
Maximilian Reiter ◽  
Ulrich Harréus
Keyword(s):  
Head And Neck ◽  
Fruits And Vegetables ◽  
Cancer Chemoprevention ◽  
Field Cancerization ◽  
Cigarette Smoke Condensate ◽  
Upper Aerodigestive Tract ◽  
High Concentration ◽  
Beneficial Effects ◽  
The Impact ◽  
Preventive Effects

Despite clear results of observational studies linking a diet rich in fruits and vegetables to a decreased cancer risk, large interventional trials evaluating the impact of dietary micronutrient supplementation, mostly vitamins, could not show any beneficial effects. Today it has become clear that a single micronutrient, given in supernutritional doses, cannot match cancer preventive effects of whole fruits and vegetables. In this regard polyphenols came into focus, not only because of their antioxidant potential but also because of their ability to interact with molecular targets within the cells. Because polyphenols occur in many foods and beverages in high concentration and evidence for their anticancer activity is best for tissues they can come into direct contact with, field cancerization predestines upper aerodigestive tract epithelium for cancer chemoprevention by polyphenols. In this paper, we summarize cancer chemopreventive attempts with emphasis on head and neck carcinogenesis and discuss some methodological issues. We present data regarding antimutagenic effects of curcumin and epigallocatechin-3-gallate in human oropharyngeal mucosa cultures exposed to cigarette smoke condensate.

Metformin Prevents the Progression of Dysplastic Mucosa of the Head and Neck to Carcinoma in Nondiabetic Patients

2017 ◽  
Vol 126 (4) ◽  
pp. 340-343 ◽  
Author(s):  
Michael Zvi Lerner ◽  
Niv Mor ◽  
Hyung Paek ◽  
Andrew Blitzer ◽  
Marshall Strome
Keyword(s):  
Head And Neck ◽  
Case Series ◽  
Field Cancerization ◽  
Metformin Therapy ◽  
Abnormal Glucose Metabolism ◽  
Clinical Literature ◽  
Increased Risk ◽  
Risk Of Malignancy ◽  
History Of

Objective: Metformin is an oral anti-hyperglycemic agent used to treat type 2 diabetes mellitus (DM). In vitro and animal models have shown that metformin can prevent the progression of oral lesions to carcinoma; however, there is conflicting data in the clinical literature regarding risk reduction for malignancy in head and neck cancer (HNC). Study Design: Case series. Methods: We present 3 cases in which adjuvant metformin therapy was used to treat recurrent and multifocal dysplastic lesions in previously treated nondiabetic HNC patients. Results: Patients included 1 with a history of oral cavity squamous cell carcinoma (SCC) and 2 with a history of laryngeal SCC. Follow-up time ranged between 3 and 33 months. All 3 patients showed complete or partial regression of the remaining mucosal lesions and did not require any additional surgeries. Conclusion: We present 3 cases of nondiabetic HNC patients with field cancerization who showed a good response to adjuvant therapy with metformin. The nondiabetic population is not affected by confounding factors such as increased risk of malignancy and decreased overall survival that is itself associated with abnormal glucose metabolism and is therefore an excellent cohort in which to study the use of adjuvant metformin therapy in HNC patients.

scholarly journals Association between head-and-neck cancers and active and passive cigarette smoking

Health ◽  
2012 ◽  
Vol 04 (09) ◽  
pp. 619-624
Author(s):  
Yukiomi Kushihashi ◽  
Yoshiyuki Kadokura ◽  
Syuhei Takiguchi ◽  
Yoshiyuki Kyo ◽  
Yoshihiro Yamada ◽  
...  
Keyword(s):  
Cigarette Smoking ◽  
Head And Neck ◽  
Head And Neck Cancers

Human papillomavirus (HPV)-related oropharyngeal cancer cofactors: Viral co-infections, second cancers, and survival trends—A single Veterans Administration (VA) institution.

2017 ◽  
Vol 35 (15_suppl) ◽  
pp. e17531-e17531
Author(s):  
George Anthony Dawson ◽  
Yue Hua Zhang ◽  
Angela Laurio ◽  
Patricia Smith ◽  
Michael Dellatto ◽  
...  
Keyword(s):  
Head And Neck ◽  
Survival Data ◽  
Oropharyngeal Cancer ◽  
Statistical Significance ◽  
Small Sample ◽  
Head And Neck Cancers ◽  
Field Cancerization ◽  
Head Neck Cancer ◽  
Second Cancers ◽  
Hpv Status

e17531 Background: Oropharyngeal cancers related to HPV are increasing in number. Common factors associated with HPV related head and neck cancers include ethnicity, young age, and low usage of alcohol and tobacco. All are typical of HPV+ related Oropharyngeal cancer in non-VA populations. Methods: This IRB approved chart review of 73 documented patients with Oropharyngeal cancers from co-HPV infections from 01/01/2011 - 12/31/2016. In this version of report we discuss second cancers, trends and other co-factors. Results: Overall trend was notable for a reversal (more HPV+ / less HPV- ) cases. All cancers were squamous cell variety. 2011 /2012 /2013/ 2014/2015/2016 HPV +: 4 / 4 / 0 / 6 / 11 / 7. HPV -: 6 / 8 / 4 / 8 / 6 / 5. Clinical stage: Evident adenopathy - (N2 to N3) was noted in 51/73(70%) cases: HPV+ 30/36 (83%) / HPV- 21/37(57%). As noted, there are ~40 co-factor events in each group with no clear association with HPV + or – status numbers of cases were too small for meaningful analysis. Second Cancers HPV+: PROSTATE 7 / BLADDER 2 / TESTICULAR 1 / RENAL 1 / LUNG 1 / SKIN 4. HPV- : FOM 2 / LARYNX 2 / TONSILLAR 1 / PAROTID 1 / BLADDER 1 / SKIN 5 / PROSTATE 1 / LUNG 1. Survival data results: There was evidence in our data that survival was prolonged in patients who are HPV negative, but this sample was too small to show statistical significance. Further, it appears white race improves the odds of survival p-value 0.073, however, not statistically significant, due to the small sample. Conclusions: As in the non-VA community, our data noted an increase in HPV+ oropharyngeal cancers treated at the Bronx VA during review period. Further, our HPV+ group had predominant advanced adenopathy, and whites had longer survival regardless of HPV status. Second cancers in HPV- group followed field cancerization effects in regards number new or old head / neck cancer events. Interestingly, with almost equal tobacco / alcohol use in both groups, no 2nd head and neck cancers in the HPV+ group were discovered. Potential immuno-protection for HPV+ 2nd h and N cancers.[Table: see text]

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