Genomic Sequencing of Cancer-related Genes in Sinonasal Squamous Cell Carcinoma and Coexisting Inverted Papilloma

2021 ◽  
Vol 41 (1) ◽  
pp. 71-79
Author(s):  
RYUTARO UCHI ◽  
RINA JIROMARU ◽  
RYUJI YASUMATSU ◽  
HIDETAKA YAMAMOTO ◽  
TAKAHIRO HONGO ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Inverted Papilloma ◽  
Genomic Sequencing

scholarly journals Concurrent Inverted Papilloma and Squamous Cell Carcinoma with Intradural Extension Presenting with Frontal Lobe Syndrome

2021 ◽  
Author(s):  
Abdul Jaleel ◽  
Pavithran V. M. ◽  
Shanavas Cholakkal ◽  
Vineeth Kadangot Kuthampulli
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Frontal Lobe ◽  
Squamous Cell ◽  
Benign Lesion ◽  
Lateral Wall ◽  
Inverted Papilloma ◽  
Intracranial Extension ◽  
Rare Presentation ◽  
Frontal Lobe Syndrome

Abstract Inverted papilloma is an uncommon tumor mostly arising from the lateral wall of the nasal cavity and displays a benign but locally aggressive behavior. Intracranial extension is an extremely rare presentation of inverted papilloma. Extension occurs either as a benign lesion or due to malignant transformation. We report a case of concurrent inverted papilloma and squamous cell carcinoma presenting with epistaxis and recent-onset altered behavior and memory impairment. After literature review of similar cases having inverted papilloma with intracranial extension, we could identify a total of 12 cases, most of which were recurrences of a primary inverted papilloma that were resected before extension into the cranial cavity. Most cases were of extradural extension, and intradural spread resulted in poor prognosis on follow-up. Concurrent inverted papilloma and squamous cell carcinoma extending into the anterior cranial fossa and frontal lobe is a very rare clinical entity and can present as frontal lobe syndrome.

Squamous Cell Carcinoma Antigen Production in Nasal Inverted Papilloma

2012 ◽  
Vol 26 (5) ◽  
pp. 365-370 ◽  
Author(s):  
Mikio Suzuki ◽  
Zeyi Deng ◽  
Masahiro Hasegawa ◽  
Takayuki Uehara ◽  
Asanori Kiyuna ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Inverted Papilloma ◽  
Squamous Cell Carcinoma Antigen ◽  
Antigen Production

scholarly journals A rare combination of polyp, inverted papilloma and squamous cell carcinoma of sphenoid sinus

2021 ◽  
Vol 7 (9) ◽  
pp. 1565
Author(s):  
Nitish Baisakhiya ◽  
Anusha Shukla ◽  
Kartikey Pande
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Sphenoid Sinus ◽  
Rare Case ◽  
Lateral Wall ◽  
Inverted Papilloma ◽  
Back Ground ◽  
Rare Site ◽  
Malignant Changes

<p class="abstract">Inverted papilloma (IP) is a tumor most commonly originates from lateral wall of nose and benign in nature. Sphenoid sinus is a rare site of origin and involvement. Malignant changes are the rare possibility in the IP. In this case report we reported a rare case of squamous cell carcinoma in back ground of inverted papilloma of sphenoid sinus.</p>

scholarly journals Outcomes of Sinonasal Squamous Cell Carcinoma with and without Association of Inverted Papilloma: A Multi-Institutional Analysis

2017 ◽  
Vol 31 (5) ◽  
pp. 305-309 ◽  
Author(s):  
Brian C. Lobo ◽  
Brian D'Anza ◽  
Janice L. Farlow ◽  
Dennis Tang ◽  
Troy D. Woodard ◽  
...  
Keyword(s):  
Overall Survival ◽  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Cleveland Clinic ◽  
Nodal Metastasis ◽  
Inverted Papilloma ◽  
Low Grade ◽  
Primary Tumors ◽  
Stage Disease

Introduction Sinonasal squamous cell carcinoma (SCC) accounts for <1% of all malignancies but represents 70% of sinonasal cancer. Up to 10% of SCCs are associated with inverted papilloma (IPSCC). Studies that compare patients, treatment, and outcomes of SCC and IPSCC are absent in the literature. Methods A retrospective review of patients with SCC and those with IPSCC at Cleveland Clinic and Indiana University from 1995 to 2015. The records were analyzed for demographics, tumor characteristics, treatment, and outcomes. Results The study comprised 117 patients with SCC, of whom, 29 had IPSCC. The mean age at diagnosis was similar: 63 and 64 years for patients with SCC and patients with IPSCC, respectively; with female patients representing 36% and 34%, respectively (p > 0.99). Smokers represented 64% of the patients with SCC and 55% of patients with IPSCC (p = 0.3); excessive alcohol intake was noted in 16% of the patients with SCC and 21% of the patients with IPSCC (p = 0.56). The maxillary sinus was most commonly involved, followed by the nasal cavity (51% versus 35% SCC, 45% versus 38% IPSCC). Frontal ethmoid and sphenoid sinuses contained primary tumors only in patients with SCC. Upfront treatment was surgery in 84% of patients with SCC and 97% of patients with IPSCC (p = 0.18); 68 and 55% received radiation, respectively, and 25 and 21% received chemotherapy, respectively. Overall survival averaged 5.5 and 3.4 years for patients with SCC and patients with IPSCC, respectively (p = 0.12); disease-free survival was 4.8 and 2.9 years, respectively (p = 0.18). Nodal metastasis was more likely in patients with SCC (18 versus 0%; p = 0.02). When divided into high- and low-stage disease: more common nodal metastases were demonstrated in high-stage SCC than in low-stage disease (p = 0.03). Overall survival was decreased between high- and low-grade disease but not when subdivided between SCC and IPSCC. Conclusion Although SCC with and without IP association are considered different diseases, their demographics and outcomes seem similar. Nodal metastasis was noted to be higher in the SCC cohort, which may indicate different tumor biology. Further study is warranted.

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