Current Role of Intraoperative Frozen Section Examination of Sentinel Lymph Node in Early Breast Cancer

2020 ◽  
Vol 40 (3) ◽  
pp. 1711-1717
Author(s):  
CALOGERO CIPOLLA ◽  
GIUSEPPA GRACEFFA ◽  
DANIELA CABIBI ◽  
GIUSEPPE GANGI ◽  
MARIO LATTERI ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Lymph Node ◽  
Sentinel Lymph Node ◽  
Early Breast Cancer ◽  
Frozen Section ◽  
Current Role ◽  
Intraoperative Frozen Section ◽  
Frozen Section Examination

scholarly journals Is there a role of frozen section of sentinel lymph node in patients with early breast cancer for the management of axilla in India: a prospective study

2019 ◽  
Vol 6 (6) ◽  
pp. 2126
Author(s):  
Anshika Arora ◽  
Neena Chauhan ◽  
Sunil Saini ◽  
Nishish Vishwakarma ◽  
Tanvi Luthra
Keyword(s):  
Breast Cancer ◽  
Lymph Node ◽  
Sentinel Lymph Node ◽  
Early Breast Cancer ◽  
False Positive ◽  
Frozen Section ◽  
False Negative ◽  
Lymph Node Biopsy ◽  
True Negative ◽  
Node Negative

Background: Evaluation of axilla using sentinel lymph node biopsy (SLNB) is the standard of care in node negative early breast cancer. Intra operative assessment of SLNB with frozen section (FS) often guides the surgeon regarding decision for level of axillary dissection. The aim of this study was to evaluate accuracy of FS of SLNB in these patients with histopathology examination (HPE) as the gold standard.Methods: This study was performed between July 2017 and November 2018. After gross evaluation of SLNB, nodes were cut in half and frozen; the other half was preserved for HPE. For FS, nodes were sectioned to 4 mm width and examined.Results: A total of 61 patients underwent SLNB, 55 patients undergoing intra-operative FS. The mean age was 53 years (range 30-84, ± 15.09 SD), primary tumor was clinically T1 in 23.6%, T2 in 76.4% patients. A median of four sentinel nodes were identified, mean size 13.84 mm. On FS SLNB was positive for metastasis in 14 (25.5%), on HPE in 16 (29.1%) patients. There were 13 true positive, 38 true negative, 3 false negative and 1 false positive result for FS. The sensitivity, specificity, positive and negative predictive value, false negative and false positive rates were 81.25%, 97.44%, 92.86%, 92.73%, 18.75% and 2.56% respectively in this study. The overall accuracy of FS of SLNB in early carcinoma breast was found to be 92.73%.Conclusions: An intra-operative FS of the SLN in node negative early breast cancer is a highly sensitive tool in axilla management.

scholarly journals Should Sentinel Lymph Node Biopsy for Patients with Early Breast Cancer be Abandoned? Not So Fast

2016 ◽  
Vol 10 ◽  
pp. CMO.S32817
Author(s):  
Quyen D. Chu ◽  
Prakash Peddi
Keyword(s):  
Breast Cancer ◽  
Lymph Node ◽  
Sentinel Lymph Node ◽  
Sentinel Lymph Node Biopsy ◽  
Early Breast Cancer ◽  
Critical Appraisal ◽  
Lymph Node Biopsy ◽  
Node Biopsy ◽  
Made In

As major advances are made in the management of early breast cancer, the role of sentinel lymph node biopsy (SLNBx) has been called into question. However, before abandoning SLNBx, a critical appraisal of its role should be done because we believe that it remains a critical component of care, especially when tailoring patient's adjuvant therapy. This commentary provides cogent arguments in favor of SLNBx in the management of patients with early breast cancer.

scholarly journals Role of total tumour load of sentinel lymph node on survival in early breast cancer patients

The Breast ◽  
2017 ◽  
Vol 33 ◽  
pp. 8-13 ◽  
Author(s):  
Vicente Peg ◽  
Irene Sansano ◽  
Begoña Vieites ◽  
Laia Bernet ◽  
Rafael Cano ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Lymph Node ◽  
Sentinel Lymph Node ◽  
Cancer Patients ◽  
Early Breast Cancer ◽  
Breast Cancer Patients ◽  
Tumour Load
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