scholarly journals Role of Phosphodiesterase2A in Proliferation and Migration of Human Osteosarcoma Cells

2019 ◽  
Vol 39 (11) ◽  
pp. 6057-6062
Author(s):  
TAKU MURATA ◽  
KASUMI SHIMIZU ◽  
KAZUTO KUROHARA ◽  
AKIRA TOMEOKU ◽  
GAKU KOIZUMI ◽  
...  
Keyword(s):  
Osteosarcoma Cells ◽  
Human Osteosarcoma ◽  
Human Osteosarcoma Cells ◽  
And Migration ◽  
Proliferation And Migration

SGP-2, an acidic polysaccharide from Sarcandra glabra, inhibits proliferation and migration of human osteosarcoma cells

2014 ◽  
Vol 5 (1) ◽  
pp. 167-175 ◽  
Author(s):  
Zhenzhen Zhang ◽  
Wei Liu ◽  
Ying Zheng ◽  
Lei Jin ◽  
Wenbing Yao ◽  
...  
Keyword(s):  
Osteosarcoma Cells ◽  
Acidic Polysaccharide ◽  
Human Osteosarcoma ◽  
Human Osteosarcoma Cells ◽  
And Migration ◽  
Proliferation And Migration

The tumor suppressive role of TIMP3 in the human osteosarcoma cells

2021 ◽  
Author(s):  
Bingyi Tan ◽  
Xiqiang Xu ◽  
Qingyu Zhang ◽  
Zenong Yuan ◽  
Jun Dong
Keyword(s):  
Osteosarcoma Cells ◽  
Human Osteosarcoma ◽  
Human Osteosarcoma Cells

scholarly journals Interfering with pak4 Protein Expression Affects Osteosarcoma Cell Proliferation and Migration

2021 ◽  
Vol 2021 ◽  
pp. 1-10
Author(s):  
Yuxin Fu ◽  
Lun Fang ◽  
Qipu Yin ◽  
Qi Wu ◽  
Wei Sui ◽  
...  
Keyword(s):  
Protein Expression ◽  
Osteosarcoma Cell ◽  
Mrna Levels ◽  
Osteosarcoma Cells ◽  
Migration Ability ◽  
M Phase ◽  
Underlying Mechanisms ◽  
And Migration ◽  
Proliferation And Migration

Purpose. A number of studies have discovered various roles of PAK4 in human tumors, including osteosarcoma. However, the exact role of PAK4 in osteosarcoma and its mechanism have yet to be determined. Therefore, this study focused on interrogating the PAK4 effect on the proliferation and migration ability of osteosarcoma and its underlying mechanisms. Materials and Methods. Western blot and QRT-PCR were utilized to quantify the PAK4 relative protein and mRNA levels. To measure cellular viability and mobility, the MTT and wound-healing assays were preferred. Results. With the adenovirus-mediated overexpression of PAK4, the proliferation and migration of U2-OS and MG-63 osteosarcoma cells were stimulated. Furthermore, a liposome-mediated knockout of PAK4 will inhibit osteosarcoma cells from proliferating. In terms of mechanism, we observed the positive correlation of PAK4 expression with expression of P21, CyclinD1, CyclinE1, CDK2, and CDK6, which drives G0/G1 to the G2/M phase transition. PAK4 can also activate Erk expression in OS cells and induce EMT. Conclusion. Interfering with PAK4 protein expression has been shown to affect osteosarcoma proliferation and migration.

scholarly journals CPNE1 silencing inhibits the proliferation, invasion and migration of human osteosarcoma cells

2017 ◽  
Author(s):  
Zhenhuan Jiang ◽  
Jiannong Jiang ◽  
Bizeng Zhao ◽  
Huilin Yang ◽  
Yunliang Wang ◽  
...  
Keyword(s):  
Osteosarcoma Cells ◽  
Invasion And Migration ◽  
Human Osteosarcoma ◽  
Human Osteosarcoma Cells ◽  
And Migration
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