scholarly journals Oxidative DNA Damage and Apoptosis Induced by Aclarubicin, an Anthracycline: Role of Hydrogen Peroxide and Copper

2019 ◽  
Vol 39 (7) ◽  
pp. 3443-3451 ◽  
Author(s):  
HIDEKI MIZUTANI ◽  
YUKA HAYASHI ◽  
MIYABI HASHIMOTO ◽  
MASANORI IMAI ◽  
YOSHIMI ICHIMARU ◽  
...  
Keyword(s):  
Hydrogen Peroxide ◽  
Dna Damage ◽  
Oxidative Dna Damage

Role of oxidative DNA damage in the mechanism of fecapentaene 12 genotoxicity

1994 ◽  
Vol 15 (11) ◽  
pp. 2559-2566 ◽  
Author(s):  
T.M.C.M. de Kok ◽  
D.M.F.A. Pachen ◽  
J.M.S. van Maanen ◽  
M.V.M. Lafleur ◽  
E.J. Westmijze ◽  
...  
Keyword(s):  
Dna Damage ◽  
Oxidative Dna Damage

scholarly journals Potential role of oxidative DNA damage in the impact of PNPLA3 variant (rs 738409 C>G) in hepatocellular carcinoma risk

Hepatology ◽  
2014 ◽  
Vol 60 (3) ◽  
pp. 1110-1111 ◽  
Author(s):  
Emeric Limagne ◽  
Vanessa Cottet ◽  
Alexia Karen Cotte ◽  
Samia Hamza ◽  
Patrick Hillon ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Dna Damage ◽  
Oxidative Dna Damage ◽  
Potential Role ◽  
The Impact ◽  
Carcinoma Risk

scholarly journals Labile iron pool correlates with iron content in the nucleus and the formation of oxidative DNA damage in mouse lymphoma L5178Y cell lines.

2003 ◽  
Vol 50 (1) ◽  
pp. 211-215 ◽  
Author(s):  
Marcin Kruszewski ◽  
Teresa Iwaneńko
Keyword(s):  
Hydrogen Peroxide ◽  
Dna Damage ◽  
Cell Lines ◽  
Oxidative Dna Damage ◽  
Transition Metal Ions ◽  
Dna Lesions ◽  
Labile Iron Pool ◽  
Labile Iron ◽  
Iron Pool ◽  
Mouse Lymphoma

Labile iron pool (LIP) constitutes a crossroad of metabolic pathways of iron-containing compounds and is midway between the cellular need for iron, its uptake and storage. In this study we investigated oxidative DNA damage in relation to the labile iron pool in a pair of mouse lymphoma L5178Y (LY) sublines (LY-R and LY-S) differing in sensitivity to hydrogen peroxide. The LY-R cells, which are hydrogen peroxide-sensitive, contain 3 times more labile iron than the hydrogen peroxide-resistant LY-S cells. Using the comet assay, we compared total DNA breakage in the studied cell lines treated with hydrogen peroxide (25 microM for 30 min at 4 degrees C). More DNA damage was found in LY-R cells than in LY-S cells. We also compared the levels of DNA lesions sensitive to specific DNA repair enzymes in both cell lines treated with H(2)O(2). The levels of endonuclease III-sensitive sites and Fapy-DNA glycosylase-sensitive sites were found to be higher in LY-R cells than in LY-S cells. Our data suggest that the sensitivity of LY-R cells to H(2)O(2) is partially caused by the higher yield of oxidative DNA damage, as compared to that in LY-S cells. The critical factor appears to be the availability of transition metal ions that take part in the OH radical-generating Fenton reaction (very likely in the form of LIP).

scholarly journals The role of metal ion binding in the antioxidant mechanisms of reduced and oxidized glutathione in metal-mediated oxidative DNA damage

Metallomics ◽  
2020 ◽  
Vol 12 (1) ◽  
pp. 79-91 ◽  
Author(s):  
Elias O. U. Eteshola ◽  
Devin A. Haupt ◽  
Stephen I. Koos ◽  
Lee A. Siemer ◽  
Daniel L. Morris
Keyword(s):  
Dna Damage ◽  
Metal Ion ◽  
Oxidative Dna Damage ◽  
Ion Binding ◽  
Oxidized Glutathione ◽  
Metal Ion Binding ◽  
Reduced And Oxidized Glutathione ◽  
Antioxidant Mechanisms

GSH and GSSG appear to function as antioxidants against metal-mediated oxidative DNA damage by coordinating Fe(ii) and Cu(ii).

DNA Damage by Dimethylformamide:  Role of Hydrogen Peroxide Generated during Degradation

2000 ◽  
Vol 13 (4) ◽  
pp. 309-315 ◽  
Author(s):  
Kaoru Midorikawa ◽  
Mariko Murata ◽  
Shinji Oikawa ◽  
Saeko Tada-Oikawa ◽  
Shosuke Kawanishi
Keyword(s):  
Hydrogen Peroxide ◽  
Dna Damage

scholarly journals The role of CSA in the response to oxidative DNA damage in human cells

Oncogene ◽  
2007 ◽  
Vol 26 (30) ◽  
pp. 4336-4343 ◽  
Author(s):  
M D'Errico ◽  
E Parlanti ◽  
M Teson ◽  
P Degan ◽  
T Lemma ◽  
...  
Keyword(s):  
Dna Damage ◽  
Oxidative Dna Damage ◽  
Human Cells
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