scholarly journals Perfluorooctanoic Acid Enhances Invasion of Follicular Thyroid Carcinoma Cells Through NF-κB and Matrix Metalloproteinase-2 Activation

2019 ◽  
Vol 39 (5) ◽  
pp. 2429-2435 ◽  
Author(s):  
PIPOP SAEJIA ◽  
KRIENGSAK LIRDPRAPAMONGKOL ◽  
JISNUSON SVASTI ◽  
N. MONIQUE PARICHARTTANAKUL
Keyword(s):  
Thyroid Carcinoma ◽  
Matrix Metalloproteinase ◽  
Follicular Thyroid Carcinoma ◽  
Perfluorooctanoic Acid ◽  
Carcinoma Cells ◽  
Matrix Metalloproteinase 2

scholarly journals Molecular Signature of Prospero Homeobox 1 (PROX1) in Follicular Thyroid Carcinoma Cells

2019 ◽  
Vol 20 (9) ◽  
pp. 2212 ◽  
Author(s):  
Magdalena Rudzińska ◽  
Małgorzata Grzanka ◽  
Anna Stachurska ◽  
Michał Mikula ◽  
Katarzyna Paczkowska ◽  
...  
Keyword(s):  
Thyroid Cancer ◽  
Thyroid Carcinoma ◽  
Follicular Thyroid Carcinoma ◽  
Carcinoma Cells ◽  
Molecular Signature ◽  
Transcriptional Analysis ◽  
Rna Seq ◽  
Cytoskeleton Organization ◽  
Transcriptional Signature ◽  
Interfering Rna

The prospero homeobox 1 (PROX1) transcription factor is a product of one of the lymphangiogenesis master genes. It has also been suggested to play a role in carcinogenesis, although its precise role in tumour development and metastasis remains unclear. The aim of this study was to gain more knowledge on the PROX1 function in thyroid tumorigenesis. Follicular thyroid cancer-derived cells—CGTH-W-1—were transfected with PROX1-siRNA (small interfering RNA) and their proliferation, cell cycle, apoptosis and motility were then analysed. The transcriptional signature of PROX1 depletion was determined using RNA-Sequencing (RNA-Seq) and the expression of relevant genes was further validated using reverse transcriptase quantitative PCR (RT-qPCR), Western blot and immunocytochemistry. PROX1 depletion resulted in a decreased cell motility, with both migratory and invasive potential being significantly reduced. The cell morphology was also affected, while the other studied cancer-related cell characteristics were not significantly altered. RNA-seq analysis revealed significant changes in the expression of transcripts encoding genes involved in both motility and cytoskeleton organization. Our transcriptional analysis of PROX1-depleted follicular thyroid carcinoma cells followed by functional and phenotypical analyses provide, for the first time, evidence that PROX1 plays an important role in the metastasis of thyroid cancer cells by regulating genes involved in focal adhesion and cytoskeleton organization in tumour cells.

Simulated microgravity alters differentiation and increases apoptosis in human follicular thyroid carcinoma cells

2002 ◽  
Vol 16 (6) ◽  
pp. 604-606 ◽  
Author(s):  
Daniela Grimm ◽  
Johann Bauer ◽  
Peter Kossmehl ◽  
Mehdi Shakibaei ◽  
Johann Schönberger ◽  
...  
Keyword(s):  
Thyroid Carcinoma ◽  
Simulated Microgravity ◽  
Follicular Thyroid Carcinoma ◽  
Carcinoma Cells

scholarly journals The role of prospero homeobox 1 (PROX1) expression in follicular thyroid carcinoma cells

Oncotarget ◽  
2017 ◽  
Vol 8 (69) ◽  
pp. 114136-114155 ◽  
Author(s):  
Magdalena Rudzinska ◽  
Joanna K. Ledwon ◽  
Damian Gawel ◽  
Justyna Sikorska ◽  
Barbara Czarnocka
Keyword(s):  
Thyroid Carcinoma ◽  
Follicular Thyroid Carcinoma ◽  
Carcinoma Cells ◽  
Prox1 Expression

Invasion of Human Follicular Thyroid Carcinoma Cells in An In Vivo Invasion Model

Thyroid ◽  
1999 ◽  
Vol 9 (12) ◽  
pp. 1221-1226 ◽  
Author(s):  
MICHAEL C. GERLING ◽  
GREGORY JOSSART ◽  
QUAN Y. DUH ◽  
HEINZ-ULRICH WEIER ◽  
ORLO H. CLARK ◽  
...  
Keyword(s):  
Thyroid Carcinoma ◽  
Follicular Thyroid Carcinoma ◽  
Carcinoma Cells ◽  
Invasion Model
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