scholarly journals Chloroquine Inhibits Self-Renewal of Blast Progenitors Synergistically With Phytochemicals or Nonsteroidal Anti-inflammatory Drugs in Hematological Malignant Cell Lines

2018 ◽  
Vol 39 (1) ◽  
pp. 87-98 ◽  
Author(s):  
NORIKO KAWAGUCHI-IHARA ◽  
YAN ZHAO ◽  
SUZUNE NAKAMURA ◽  
KEIKO SUZUKI ◽  
YI ZHANG ◽  
...  
Keyword(s):  
Cell Lines ◽  
Malignant Cell ◽  
Self Renewal ◽  
Inflammatory Drugs ◽  
Anti Inflammatory

Non-steroidal anti-inflammatory drugs inhibit telomerase activity in head and neck squamous carcinoma cell lines

Head & Neck ◽  
2001 ◽  
Vol 23 (12) ◽  
pp. 1049-1055 ◽  
Author(s):  
Dietmar Thurnher ◽  
Maia Bakroeva ◽  
Michael Formanek ◽  
Birgit Knerer ◽  
Johannes Kornfehl
Keyword(s):  
Head And Neck ◽  
Cell Lines ◽  
Carcinoma Cell ◽  
Squamous Carcinoma ◽  
Telomerase Activity ◽  
Carcinoma Cell Lines ◽  
Inflammatory Drugs ◽  
Anti Inflammatory ◽  
Squamous Carcinoma Cell

Nonsteroidal anti-inflammatory drugs inhibit the growth of C6 and U138-MG glioma cell lines

2006 ◽  
Vol 532 (3) ◽  
pp. 214-222 ◽  
Author(s):  
Andressa Bernardi ◽  
Maria C. Jacques-Silva ◽  
Andrés Delgado-Cañedo ◽  
Guido Lenz ◽  
Ana M.O. Battastini
Keyword(s):  
Cell Lines ◽  
Glioma Cell ◽  
Glioma Cell Lines ◽  
Inflammatory Drugs ◽  
Anti Inflammatory

scholarly journals Effects of Nonsteroidal Anti-inflammatory Drugs on the Self-renewal Capacity of Blast Progenitors in Hematological Malignancies

2017 ◽  
Vol 37 (5) ◽  
pp. 2315-2322
Author(s):  
ZHANG YAN ◽  
KAZUMA MIYAHARA ◽  
MAI SHIMADA ◽  
KEN-ICHI TANAKA ◽  
HIROYUKI HAYASHI ◽  
...  
Keyword(s):  
Hematological Malignancies ◽  
The Self ◽  
Self Renewal ◽  
Inflammatory Drugs ◽  
Anti Inflammatory

Non-Steroidal Anti-Inflammatory Drugs and Imatinib; Drug Interactions That May Impact Efficacy,

Blood ◽  
2011 ◽  
Vol 118 (21) ◽  
pp. 3501-3501
Author(s):  
Jueqiong Wang ◽  
Timothy P Hughes ◽  
Chung Hoow Kok ◽  
Verity A Saunders ◽  
Amity Frede ◽  
...  
Keyword(s):  
Board Of Directors ◽  
Cell Lines ◽  
Research Funding ◽  
Viable Cell ◽  
Viable Cell Number ◽  
Advisory Committees ◽  
Trypan Blue Exclusion Method ◽  
Inflammatory Drugs ◽  
Anti Inflammatory ◽  
The Impact

Abstract Abstract 3501 Aim: The human organic cation transporter-1 (OCT-1) is the primary active influx protein for imatinib (IM) into target BCR-ABL-positive cells. The functional activity of the OCT-1 protein (OCT-1 activity; OA) is predictive of molecular response and event-free survival in de-novo chronic phase chronic myeloid leukemia (CP-CML) patients. Due to the common use of non-steroidal anti-inflammatory drugs (NSAIDs) among CML patients on IM to treat musculoskeletal pain, it is of particular interest to investigate the impact of NSAIDs on OCT-1 mediated IM uptake. Methods: 12 NSAIDs were firstly examined for their impact on OA using the intracellular uptake and retention (IUR) assay and [14-C]-IM. The degree of in vitro kinase inhibition achieved was assessed using p-Crkl in the IC50imatinib assay. Viable cell numbers were determined by trypan blue exclusion method after 72 hours incubation with the co-administration of NSAIDs and IM. NSAIDs concentration was adjusted to median blood levels on standard doses. Results: The majority of NSAIDs (10 of 12) selected did not induce any significant change in OA in CML cell lines. Compared to control cells, increased OA were observed when K562 or KU812 cells were treated with diclofenac (10μM), and this resulted in a concomitant decrease in the IC50imatinib. In keeping with this, after 72 hours co-incubation with IM, diclofenac resulted in a significantly lower viable cell number compared with IM alone. In contrast, ibuprofen (130μM) led to a significant decrease in OA, resulting in an increased IC50imatinib and thus reduced the inhibition of IM on cell growth number (Table 1). The effects of diclofenac and ibuprofen on IM efficacy were then further investigated using primary samples. In keeping with the results observed in cell lines, diclofenac resulted in significant increases in OA, which translated to a significant decrease in IC50imatinib. Ibuprofen induced significant decreases in OA in all patients and healthy donors (Table 1). Conclusion: These finding provide strong evidence for interactions between some NSAIDs and IM which may substantially impact the response of CML patients to IM. While drugs such as diclofenac are likely to have a positive influence on IM efficacy, the findings observed with ibuprofen suggest caution when administrating NSAIDs to CML patients on IM treatment. Disclosures: Hughes: Novartis: Honoraria, Membership on an entity's Board of Directors or advisory committees, Research Funding; BMS: Honoraria, Membership on an entity's Board of Directors or advisory committees, Research Funding; ARIAD: Honoraria, Membership on an entity's Board of Directors or advisory committees. Osborn:Novartis: Research Funding. White:Novartis Pharmaceuticals: Research Funding; BMS: Research Funding.

Evaluation of the antitumoral potential of different nitric oxide-donating non-steroidal anti-inflammatory drugs (NO-NSAIDs) on human urological tumor cell lines

2005 ◽  
Vol 218 (2) ◽  
pp. 163-170 ◽  
Author(s):  
Sandra Huguenin ◽  
Francis Vacherot ◽  
Jocelyne Fleury-Feith ◽  
Jean-Pierre Riffaud ◽  
Dominique K. Chopin ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Tumor Cell ◽  
Cell Lines ◽  
Tumor Cell Lines ◽  
Inflammatory Drugs ◽  
Anti Inflammatory
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