Evaluation of the antitumoral potential of different nitric oxide-donating non-steroidal anti-inflammatory drugs (NO-NSAIDs) on human urological tumor cell lines

2005 ◽  
Vol 218 (2) ◽  
pp. 163-170 ◽  
Author(s):  
Sandra Huguenin ◽  
Francis Vacherot ◽  
Jocelyne Fleury-Feith ◽  
Jean-Pierre Riffaud ◽  
Dominique K. Chopin ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Tumor Cell ◽  
Cell Lines ◽  
Tumor Cell Lines ◽  
Inflammatory Drugs ◽  
Anti Inflammatory

scholarly journals Antiproliferative Activity of Pt(IV) Conjugates Containing the Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) Ketoprofen and Naproxen †

2019 ◽  
Vol 20 (12) ◽  
pp. 3074 ◽  
Author(s):  
Mauro Ravera ◽  
Ilaria Zanellato ◽  
Elisabetta Gabano ◽  
Elena Perin ◽  
Beatrice Rangone ◽  
...  
Keyword(s):  
Tumor Cell ◽  
Cell Lines ◽  
Transforming Growth Factor Beta ◽  
Antiproliferative Activity ◽  
Transforming Growth Factor ◽  
Human Tumor ◽  
Tumor Cell Lines ◽  
Dual Action ◽  
Inflammatory Drugs ◽  
Anti Inflammatory

Cisplatin and several non-steroidal anti-inflammatory drugs (NSAIDs) have been proven to act synergistically or at least additively on several tumor cell lines. Dual-action cisplatin-based Pt(IV) combos containing ketoprofen and naproxen offer good antiproliferative performance on a panel of human tumor cell lines, including a malignant pleural mesothelioma (MPM) one, a very chemoresistant tumor. The main reason of the increased activity relies on the enhanced lipophilicity of these Pt(IV) conjugates that in turn promotes increased cellular accumulation. A quick Pt(IV)→Pt(II) reduction generates the active cisplatin metabolite. The NSAID adjuvant action seems to be almost independent from cyclooxygenase-2 (COX-2) expression in the tumor cells under investigation (lung A-549, colon HT-29, HCT 116, SW480, ovarian A2780, and biphasic MPM MSTO-211H), but it seems to rely (at least in part) on the activation of the NSAID activated gene, NAG-1 (a member of the transforming growth factor beta, TGF-β, superfamily), which has been suggested to be involved in NSAID antiproliferative activity.

Long-term adaptation of breast tumor cell lines to high concentrations of nitric oxide

Tumor Biology ◽  
2010 ◽  
Vol 31 (4) ◽  
pp. 267-275 ◽  
Author(s):  
Benjamin J. Vesper ◽  
Kim M. Elseth ◽  
Gabor Tarjan ◽  
G. Kenneth Haines ◽  
James A. Radosevich
Keyword(s):  
Nitric Oxide ◽  
Tumor Cell ◽  
Cell Lines ◽  
Breast Tumor ◽  
Tumor Cell Lines ◽  
Breast Tumor Cell ◽  
High Concentrations

scholarly journals In Vitro Interactions of Moroccan Propolis Phytochemical’s on Human Tumor Cell Lines and Anti-Inflammatory Properties

Biomolecules ◽  
2019 ◽  
Vol 9 (8) ◽  
pp. 315 ◽  
Author(s):  
Soraia I. Falcão ◽  
Ricardo C. Calhelha ◽  
Soumaya Touzani ◽  
Badiaâ Lyoussi ◽  
Isabel C. F. R. Ferreira ◽  
...  
Keyword(s):  
Phenolic Compounds ◽  
Tumor Cell ◽  
Cell Lines ◽  
Human Tumor ◽  
Inflammatory Activity ◽  
Tumor Cell Lines ◽  
Human Tumor Cell ◽  
Cell Lung Carcinoma ◽  
Human Tumor Cell Lines ◽  
Anti Inflammatory

Propolis is a resin manufactured by bees through the mixture of plant exudates and waxes with secreted substances from their metabolism, resulting in a complex mixture of natural substances of which quality depends on the phytogeographic and climatic conditions around the hive. The present study investigated the contribution of phenolic compounds to the cytotoxic and anti-inflammatory activities of propolis. The phenolic composition was evaluated by liquid chromatography with diode-array detection coupled to electrospray ionization tandem mass spectrometry (LC/DAD/ESI-MSn) analysis after phenolic extraction. The cytotoxicity of the extracts was checked using human tumor cell lines (MCF7- breast adenocarcinoma, NCI-H460- non-small cell lung carcinoma, HeLa- cervical carcinoma, HepG2- hepatocellular carcinoma, and MM127- malignant melanoma), as well as non-tumor cells (a porcine liver primary culture-PLP2). The anti-inflammatory activity was assessed using the murine macrophage (RAW 264.7) cell line. The results showed a composition rich in phenolic acids, such as caffeic and p-coumaric acid, as well as flavonoids, such as pinocembrin, pinobanksin, and pinobanksin-3-O-butyrate. Samples MP2 from Sefrou and MP3 from Moulay Yaâcoub presented a high concentration in phenolic compounds, while MP1 and MP4 from Boulemane and Immouzzer Mermoucha, respectively, showed similar composition with low bioactivity. The higher concentration of phenolic compound derivatives, which seems to be the most cytotoxic phenolic class, can explain the pronounced antitumor and anti-inflammatory activity observed for sample MP2.

Cytotoxicity against tumor cell lines and anti-inflammatory properties of chitinases from Calotropis procera latex

2017 ◽  
Vol 390 (10) ◽  
pp. 1005-1013 ◽  
Author(s):  
Carolina Araújo Viana ◽  
Márcio V. Ramos ◽  
José Delano Barreto Marinho Filho ◽  
Letícia Veras Costa Lotufo ◽  
Ingrid Samantha Tavares Figueiredo ◽  
...  
Keyword(s):  
Tumor Cell ◽  
Cell Lines ◽  
Calotropis Procera ◽  
Tumor Cell Lines ◽  
Anti Inflammatory

Necrotic tumor cells oppositely affect nitric oxide production in tumor cell lines and macrophages

2002 ◽  
Vol 215 (1) ◽  
pp. 72-77 ◽  
Author(s):  
Djordje Miljkovic ◽  
Milos Markovic ◽  
Natalija Bogdanovic ◽  
Marija Mostarica Stojkovic ◽  
Vladimir Trajkovic
Keyword(s):  
Nitric Oxide ◽  
Tumor Cell ◽  
Tumor Cells ◽  
Cell Lines ◽  
Nitric Oxide Production ◽  
Tumor Cell Lines ◽  
Oxide Production ◽  
Necrotic Tumor

Selective radiosensitization by nitric oxide in tumor cell lines

2007 ◽  
Vol 248 (1) ◽  
pp. 123-130 ◽  
Author(s):  
Lucía Policastro ◽  
Hebe Duran ◽  
Yann Henry ◽  
Beatriz Molinari ◽  
Vincent Favaudon
Keyword(s):  
Nitric Oxide ◽  
Tumor Cell ◽  
Cell Lines ◽  
Tumor Cell Lines

Novel Resveratrol-chalcone Derivatives: Synthesis and Biological Evaluation

2019 ◽  
Vol 19 (5) ◽  
pp. 424-436 ◽  
Author(s):  
Yulu Ma ◽  
Xi Zheng ◽  
Ping Zhu ◽  
Bei Liu ◽  
Hui Gao ◽  
...  
Keyword(s):  
Tumor Cell ◽  
Cell Lines ◽  
Biological Activities ◽  
Human Tumor ◽  
Biological Evaluation ◽  
Tumor Cell Lines ◽  
Human Tumor Cell ◽  
Human Tumor Cell Lines ◽  
Proliferative Effect ◽  
Anti Inflammatory

Introduction: Resveratrol and chalcones are lead compounds with good biological activities. </P><P> Method: In this study, a series of novel derivatives (6-38) between resveratrol and chalcone possessing piperazine moiety have been synthesized, and in vitro anti-inflammatory activity in lipopolysaccharide (LPS)-stimulated RAW-264.7 macrophages and anti-proliferative effect on a panel of human tumor cell lines (Hela, A549 and SGC7901) by MTT assay were evaluated. </P><P> Result: The results demonstrated that the substituents of the NH group of piperazine ring had an obvious influence on biological activities. Especially, compounds 13, 17, 30, 31 and 36 showed good inhibitory effect on the generation of NO compared to dexamethasone. Furthermore, analogs 20, 21, 22 and 25 were found to be the better anti-proliferative effect on 3 human tumor cell lines, which were found to be a better cytotoxic activity to positive control 5-FU. Many compounds displayed low cytotoxic effect on normal cells L02. </P><P> Conclusion: Further FACs analysis showed that compounds 20 and 25 significantly induced apoptosis in A549 cell. These derivatives were considered as the potential anti-inflammatory and anti-tumor agents.

A cohort of supporting metabolic enzymes is coinduced with nitric oxide synthase in human tumor cell lines

1996 ◽  
Vol 103 (1) ◽  
pp. 79-84 ◽  
Author(s):  
Andreas K. Nussler ◽  
Zhi-Ze Liu ◽  
Kazuyuki Hatakeyama ◽  
David A. Geller ◽  
Timothy R. Billiar ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Nitric Oxide Synthase ◽  
Tumor Cell ◽  
Cell Lines ◽  
Human Tumor ◽  
Metabolic Enzymes ◽  
Tumor Cell Lines ◽  
Human Tumor Cell ◽  
Human Tumor Cell Lines ◽  
Oxide Synthase

scholarly journals Long-Term Adaptation of Lung Tumor Cell Lines with Increasing Concentrations of Nitric Oxide Donor

2009 ◽  
Vol 2 (1) ◽  
pp. 35-44 ◽  
Author(s):  
James A. Radosevich ◽  
Kim M. Elseth ◽  
Benjamin J. Vesper ◽  
Gabor Tarjan ◽  
G. Kenneth Haines III
Keyword(s):  
Nitric Oxide ◽  
Tumor Cell ◽  
Cell Lines ◽  
Lung Tumor ◽  
Nitric Oxide Donor ◽  
Tumor Cell Lines ◽  
Lung Tumor Cell
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