Perioperative Red Blood Cell Transfusion Is Associated with Poor Long-term Survival in Pancreatic Adenocarcinoma

2017 ◽  
Vol 37 (10) ◽  
Keyword(s):  
Blood Cell ◽  
Pancreatic Adenocarcinoma ◽  
Red Blood Cell ◽  
Red Blood Cell Transfusion ◽  
Term Survival ◽  
Long Term Survival

Perioperative 1- to 2-Unit Red Blood Cell Transfusion Is Associated with Decreased Short-Term, but Not Long-Term Survival

2010 ◽  
Vol 110 (3) ◽  
pp. 972
Author(s):  
Stephen D. Surgenor ◽  
Charles A. S. Marrin ◽  
Bruce J. Leavitt ◽  
Jeremy R. Morton ◽  
Robert S. Kramer ◽  
...  
Keyword(s):  
Blood Cell ◽  
Red Blood Cell ◽  
Red Blood Cell Transfusion ◽  
Short Term ◽  
Term Survival ◽  
Long Term Survival

The impact of perioperative red blood cell transfusion on long-term survival after hepatectomy for colorectal liver metastases.

2015 ◽  
Vol 33 (3_suppl) ◽  
pp. 725-725 ◽  
Author(s):  
Julie I. Hallet ◽  
Melanie Tsang ◽  
Eva Cheng ◽  
Iryna B. Kulyk ◽  
Sherif Hanna ◽  
...  
Keyword(s):  
Blood Cell ◽  
Liver Metastases ◽  
Red Blood Cell ◽  
Colorectal Liver Metastases ◽  
Red Blood Cell Transfusion ◽  
Term Survival ◽  
Long Term Survival ◽  
Cox Regression Analysis ◽  
The Impact

725 Background: Perioperative red blood cell transfusions (RBCT) are associated with postoperative morbidity and may increase cancer recurrence through immunologic mechanisms following resection of colorectal liver metastases (CRLM). We sought to explore the relationship between RBCTs and long-term survival following resection of CRLM in the contemporary surgical era. Methods: We conducted a retrospective review of a prospective database including all patients undergoing partial hepatectomy for CRLM from 2003-2012. Data regarding date of death was abstracted from a validated, population-based cancer registry. Primary outcome was overall survival (OS), compared based on RBCT (defined as time of surgery to 30 days following surgery) and on number of RBC units received using Kaplan-Meier curves. Cox regression analysis was performed to examine the association between RBCT and OS, while adjusting for prognostic factors including Fong score and period of treatment (2003-2007 vs. 2008-2012). Results: We included 483 patients operated for CRLM, of which 27.5% received RBCT. 90-day post-operative mortality was 4.8% and median follow-up was 33 (IQR: 20.1-54.8) months. Median survival in patients who received RBCT was 44.5 months compared with 93.5 months in patients who did not(p<0.0001). The difference persisted in subgroup analysis excluding patients who died within 90 days of surgery (62.3 vs. 93.5 months, p=0.023). After adjustment for Fong score and period of treatment, RBCT was independently associated with decreased OS (HR 2.15; 95% CI: 1.52-3.04). Conclusions: Perioperative RBCT is independently associated with decreased OS following hepatectomy for CRLM. Interventions to minimize and rationalize the use of RBCT for hepatectomy are warranted in order to mitigate this detrimental effect on long-term outcomes.

The Association of Perioperative Red Blood Cell Transfusions and Decreased Long-Term Survival After Cardiac Surgery

2009 ◽  
Vol 108 (6) ◽  
pp. 1741-1746 ◽  
Author(s):  
Stephen D. Surgenor ◽  
Robert S. Kramer ◽  
Elaine M. Olmstead ◽  
Cathy S. Ross ◽  
Frank W. Sellke ◽  
...  
Keyword(s):  
Cardiac Surgery ◽  
Blood Cell ◽  
Red Blood Cell ◽  
Term Survival ◽  
Long Term Survival ◽  
Red Blood Cell Transfusions

scholarly journals Identification of KRAS G12V associated clonal neoantigens and immune microenvironment in long-term survival of pancreatic adenocarcinoma

2021 ◽  
Author(s):  
Chao Wang ◽  
Min Shi ◽  
Lei Zhang ◽  
Jun Ji ◽  
Ruyan Xie ◽  
...  
Keyword(s):  
Pancreatic Adenocarcinoma ◽  
Genomic Analysis ◽  
Molecular Characteristics ◽  
Immune Microenvironment ◽  
Term Survival ◽  
Long Term Survival ◽  
Tumor Immune Microenvironment ◽  
Genetic Features ◽  
Multiple Recurrences

Abstract Objective To investigate the molecular characteristics in tumor immune microenvironment that affect long-term survival of patients with pancreatic adenocarcinoma (PAAD). Methods The tumor related genetic features of a female PAAD patient (over 13-year survival) who suffered from multiple recurrences and metastases, and six operations over one decade were investigated deeply. Genomic features and immune microenvironment signatures of her primary lesion as well as six metastatic tumors at different time-points were characterized. Results High-frequency clonal neoantigenic mutations identified in these specimens revealed the significant associations between clonal neoantigens with her prognosis after each surgery. Meanwhile, the TCGA and ICGC databases were employed to analyse the function of KRAS G12V in pancreatic cancer. Conclusions The genomic analysis of clonal neoantigens combined with tumor immune microenvironment could promote the understandings of personalized prognostic evaluation and the stratification of resected PAAD individuals with better outcome.

Sign in / Sign up

Export Citation Format

Share Document