Long Term Survival After Pancreatic Resection for Pancreatic Adenocarcinoma

2002 ◽  
Vol 40 (09) ◽  
pp. 849-852
Author(s):  
M Wirtz ◽  
H Friess
Keyword(s):  
Pancreatic Adenocarcinoma ◽  
Pancreatic Resection ◽  
Term Survival ◽  
Long Term Survival

Long term survival after pancreatic resection for pancreatic adenocarcinoma

2001 ◽  
Vol 96 (9) ◽  
pp. 2609-2615 ◽  
Author(s):  
Nuzhat A. Ahmad ◽  
James D. Lewis ◽  
Gregory G. Ginsberg ◽  
Daniel G. Haller ◽  
Jon B. Morris ◽  
...  
Keyword(s):  
Pancreatic Adenocarcinoma ◽  
Pancreatic Resection ◽  
Term Survival ◽  
Long Term Survival

Long term survival after pancreatic resection for pancreatic adenocarcinoma

2000 ◽  
Vol 95 (9) ◽  
pp. 2472-2472
Author(s):  
Nuzhat A. Ahmad ◽  
James D. Lewis ◽  
Gregory G. Ginsberg ◽  
Ernest F. Rosato ◽  
Daniel G. Haller ◽  
...  
Keyword(s):  
Pancreatic Adenocarcinoma ◽  
Pancreatic Resection ◽  
Term Survival ◽  
Long Term Survival

scholarly journals Identification of KRAS G12V associated clonal neoantigens and immune microenvironment in long-term survival of pancreatic adenocarcinoma

2021 ◽  
Author(s):  
Chao Wang ◽  
Min Shi ◽  
Lei Zhang ◽  
Jun Ji ◽  
Ruyan Xie ◽  
...  
Keyword(s):  
Pancreatic Adenocarcinoma ◽  
Genomic Analysis ◽  
Molecular Characteristics ◽  
Immune Microenvironment ◽  
Term Survival ◽  
Long Term Survival ◽  
Tumor Immune Microenvironment ◽  
Genetic Features ◽  
Multiple Recurrences

Abstract Objective To investigate the molecular characteristics in tumor immune microenvironment that affect long-term survival of patients with pancreatic adenocarcinoma (PAAD). Methods The tumor related genetic features of a female PAAD patient (over 13-year survival) who suffered from multiple recurrences and metastases, and six operations over one decade were investigated deeply. Genomic features and immune microenvironment signatures of her primary lesion as well as six metastatic tumors at different time-points were characterized. Results High-frequency clonal neoantigenic mutations identified in these specimens revealed the significant associations between clonal neoantigens with her prognosis after each surgery. Meanwhile, the TCGA and ICGC databases were employed to analyse the function of KRAS G12V in pancreatic cancer. Conclusions The genomic analysis of clonal neoantigens combined with tumor immune microenvironment could promote the understandings of personalized prognostic evaluation and the stratification of resected PAAD individuals with better outcome.

scholarly journals Does long-term survival exist in pancreatic adenocarcinoma?

2015 ◽  
Vol 55 (3) ◽  
pp. 259-264 ◽  
Author(s):  
Myrte Zijlstra ◽  
Nienke Bernards ◽  
Ignace H. J. T. de Hingh ◽  
Agnes J. van de Wouw ◽  
Swan Hoo Goey ◽  
...  
Keyword(s):  
Pancreatic Adenocarcinoma ◽  
Term Survival ◽  
Long Term Survival

scholarly journals Does race affect the long-term survival benefit of systemic therapy in pancreatic adenocarcinoma?

HPB ◽  
2021 ◽  
Vol 23 ◽  
pp. S574-S575
Author(s):  
A. Irfan ◽  
H.A. Fang ◽  
S. Awad ◽  
A.M. Alkashah ◽  
S.M. Vickers ◽  
...  
Keyword(s):  
Pancreatic Adenocarcinoma ◽  
Systemic Therapy ◽  
Survival Benefit ◽  
Term Survival ◽  
Long Term Survival

Prognostic factors and long-term outcomes of resected pancreatic adenocarcinoma: A comparison between two decades.

2014 ◽  
Vol 32 (3_suppl) ◽  
pp. 318-318
Author(s):  
Pablo Emilio Serrano Aybar ◽  
Peter Tae Wan Kim ◽  
Kenneth Leung ◽  
Sean P. Cleary ◽  
Carol-anne Moulton ◽  
...  
Keyword(s):  
Overall Survival ◽  
Adjuvant Therapy ◽  
Pancreatic Adenocarcinoma ◽  
Median Overall Survival ◽  
Tumor Grade ◽  
Recent Decade ◽  
Term Survival ◽  
Long Term Survival ◽  
Short And Long Term

318 Background: There have been improvements in short and long-term survival rates for patients with resected pancreatic adenocarcinoma over time The main objective of this study was to evaluate differences in long-term survival in a cohort of patients with resected pancreatic adenocarcinoma. Methods: This is a retrospective cohort study of patients who underwent pancreatic resection for pancreatic adenocarcinoma over 2 decades at a high volume academic centre. Univariate and multivariate analysis using Cox proportional hazards model were performed to evaluate prognostic factors associated with long-term survival. Time trend analyses were performed to evaluate differences between decades. Results: There were 489 patients identified, 179 patients during the early (1991-2000) and 310 during the recent decade (2001-2010). Main differences between early and recent decade were: node-positive disease rate (59% vs. 69%), number of lymph nodes collected (median 7 vs. 17), perioperative mortality (6.7% vs. 1.6%) and percentage of patients receiving adjuvant therapy (33% vs. 68%), respectively. There were no differences in sex distribution, age, margin positivity rate or tumor grade. In the multivariate analysis, node, margin status, tumor grade, adjuvant therapy and decade of resection were independently associated with overall survival for the entire cohort. Patients who received adjuvant therapy had better median overall survival: 17 [95% confidence interval (CI): 14-22] vs. 26 months (95% CI: 24-31). Median overall survival for the early and recent decade were 16 months (95% CI: 14-20) and 27 months (95% CI: 24-30, p<0.001), respectively. Conclusions: Factors associated with improved long-term survival remain comparable over time: low tumor grade, node and margin negative disease. Short and long-term survival for patients with resected pancreatic adenocarcinoma has improved in the recent decade. This is due to decreased perioperative mortality and increase use of adjuvant therapy.

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