scholarly journals Three-dimensional structure of the catalytic domain of chitinase Al from Bacillus circulars WL-12 at a very high resolution

1999 ◽  
Vol 75 (9) ◽  
pp. 269-274 ◽  
Author(s):  
Takuo MATSUMOTO ◽  
Takamasa NONAKA ◽  
Masayuki HASHIMOTO ◽  
Takeshi WATANABE ◽  
Yukio MITSUI
Keyword(s):  
High Resolution ◽  
Catalytic Domain ◽  
Three Dimensional ◽  
Dimensional Structure ◽  
Three Dimensional Structure ◽  
Very High

scholarly journals High Resolution Crystal Structure of the Catalytic Domain of ADAMTS-5 (Aggrecanase-2)

2007 ◽  
Vol 283 (3) ◽  
pp. 1501-1507 ◽  
Author(s):  
Huey-Sheng Shieh ◽  
Karl J. Mathis ◽  
Jennifer M. Williams ◽  
Robert L. Hills ◽  
Joe F. Wiese ◽  
...  
Keyword(s):  
Crystal Structure ◽  
High Resolution ◽  
Catalytic Domain ◽  
Three Dimensional ◽  
Dimensional Structure ◽  
Direct Role ◽  
Three Dimensional Structure ◽  
High Resolution Structure ◽  
A Disintegrin And Metalloproteinase ◽  
Resolution Structure

Aggrecanase-2 (a disintegrin and metalloproteinase with thrombospondin motifs-5 (ADAMTS-5)), a member of the ADAMTS protein family, is critically involved in arthritic diseases because of its direct role in cleaving the cartilage component aggrecan. The catalytic domain of aggrecanase-2 has been refolded, purified, and crystallized, and its three-dimensional structure determined to 1.4Å resolution in the presence of an inhibitor. A high resolution structure of an ADAMTS/aggrecanase protein provides an opportunity for the development of therapeutics to treat osteoarthritis.

scholarly journals Advances in Determination of a High-Resolution Three-Dimensional Structure of Rhodopsin, a Model of G-Protein-Coupled Receptors (GPCRs)†,‡

Biochemistry ◽  
2001 ◽  
Vol 40 (26) ◽  
pp. 7761-7772 ◽  
Author(s):  
David C. Teller ◽  
Tetsuji Okada ◽  
Craig A. Behnke ◽  
Krzysztof Palczewski ◽  
Ronald E. Stenkamp
Keyword(s):  
High Resolution ◽  
G Protein ◽  
Three Dimensional ◽  
G Protein Coupled Receptors ◽  
Dimensional Structure ◽  
Three Dimensional Structure ◽  
G Protein Coupled

Freeze-etching studies on muscle

1971 ◽  
Vol 261 (837) ◽  
pp. 139-142 ◽  
Keyword(s):  
High Resolution ◽  
Striated Muscle ◽  
Three Dimensional ◽  
Dimensional Structure ◽  
Low Resolution ◽  
Three Dimensional Structure ◽  
Membrane Particles ◽  
New Information ◽  
Biological Interest ◽  
Freeze Etching

The technique of freeze-etching is illustrated with reference to striated muscle. Besides features of immediate biological interest, the material demonstrates various ways in which the process may be used in general to yield new information. These fall broadly into two classes: ( a ) qualitative: visualizing structures not readily seen by other methods, for example, general three-dimensional structure (low resolution) and membrane particles (high resolution); ( b ) quantitative, for example, the distribution of membrane features over extensive uneven surfaces (low and high resolution).

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