scholarly journals Pazopanib-mediated Long-term Disease Stabilization after Local Recurrence and Distant Metastasis of Primary Intracranial Leiomyosarcoma: A Case Report on the Efficacy of Pazopanib as a Salvage Therapy

2018 ◽  
Vol 5 (1) ◽  
pp. 1-7 ◽  
Author(s):  
Yasuhiro Kawabata ◽  
Tomokazu Aoki ◽  
Tetsurou Yamamoto ◽  
Hisateru Yasui ◽  
Satoru Sawai ◽  
...  
Keyword(s):  
Case Report ◽  
Local Recurrence ◽  
Distant Metastasis ◽  
Salvage Therapy ◽  
Disease Stabilization

Tumor Regression Grading After Preoperative Chemoradiotherapy for Locally Advanced Rectal Carcinoma Revisited: Updated Results of the CAO/ARO/AIO-94 Trial

2014 ◽  
Vol 32 (15) ◽  
pp. 1554-1562 ◽  
Author(s):  
Emmanouil Fokas ◽  
Torsten Liersch ◽  
Rainer Fietkau ◽  
Werner Hohenberger ◽  
Tim Beissbarth ◽  
...  
Keyword(s):  
Local Recurrence ◽  
Tumor Cells ◽  
Rectal Carcinoma ◽  
Distant Metastasis ◽  
Cumulative Incidence ◽  
Tumor Regression ◽  
Preoperative Chemoradiotherapy ◽  
Regression Grading ◽  
Clinicopathologic Parameters

Purpose We previously described the prognostic impact of tumor regression grading (TRG) on the outcome of patients with rectal carcinoma treated with preoperative chemoradiotherapy (CRT) in the CAO/ARO/AIO-94 trial. Here we report long-term results after a median follow-up of 132 months. Patients and Methods TRG after preoperative CRT was determined in 386 surgical specimens by the amount of viable tumor cells versus fibrosis, ranging from TRG 4 (no viable tumor cells) to TRG 0 (no signs of regression). Clinicopathologic parameters and TRG were correlated to the cumulative incidence of local recurrence, distant metastasis, and disease-free survival (DFS). Results Ten-year cumulative incidence of distant metastasis and DFS were 10.5% and 89.5% for patients with TRG 4 (complete regression), 29.3% and 73.6% for TRG 2 and 3 (intermediate regression), and 39.6% and 63% for TRG 0 and 1 (poor regression), respectively (P = .005 and P = .008, respectively). On multivariable analysis, residual lymph node metastasis (ypN+) and TRG were the only independent prognostic factors for cumulative incidence of distant metastasis (P < .001 and P = .035, respectively) and DFS (P < .001 and P = .039, respectively), whereas local recurrence was significantly affected by ypN status (P < .001) and lymphatic invasion (P = .026). Conclusion Complete and intermediate tumor regressions were associated with improved long-term outcome in patients with rectal carcinoma after preoperative CRT independent of clinicopathologic parameters. This classification system needs to be prospectively tested in multiple data sets to validate its reproducibility in a wider setting.

scholarly journals Pazopanib-mediated long-term disease stabilization after resection of a uterine leiomyosarcoma metastasis to the brain: A case report

2016 ◽  
Vol 17 ◽  
pp. 60-64 ◽  
Author(s):  
Kayo Inoue ◽  
Hiroshi Tsubamoto ◽  
Yusuke Tomogane ◽  
Mariko Kamihigashi ◽  
Hiroaki Shibahara
Keyword(s):  
Case Report ◽  
Uterine Leiomyosarcoma ◽  
Disease Stabilization ◽  
The Brain

CHONDROSARCOMA OF THUMB METACARPAL — A CASE REPORT WITH LITERATURE REVIEW

Hand Surgery ◽  
2001 ◽  
Vol 06 (01) ◽  
pp. 81-87 ◽  
Author(s):  
G. Pathak ◽  
W. B. Conolly ◽  
S. W. McCarthy
Keyword(s):  
Case Report ◽  
Local Recurrence ◽  
Literature Review ◽  
Distant Metastasis ◽  
Iliac Crest ◽  
Functional Result ◽  
The Other ◽  
Iliac Crest Bone Grafting ◽  
Ray Amputation ◽  
Uncommon Neoplasm

Function preserving management of a dominant thumb metacarpal chondrosarcoma is reported, with a literature review for this uncommon neoplasm. Wide local excision of the metacarpal followed by temporary silicone block interposition and definitive iliac crest bone grafting was performed. A persistent wound defect was managed by a radial artery forearm flap. The functional result was acceptable. In the literature, there were seven cases of thumb metacarpal chondrosarcoma reported; two were treated by ray amputation, and the other five were treated by excision of the metacarpal. Three of those five had bone graft and the other two had simple resection. Of these seven cases, three had local recurrence and one a distant metastasis.

scholarly journals Paratesticular Leiomyosarcoma: A Case Report

2013 ◽  
Vol 52 (191) ◽  
Author(s):  
Vijaya Patil ◽  
Ashish Verma ◽  
Ravindra S. Pattar ◽  
Sanjay Nandar
Keyword(s):  
Case Report ◽  
Local Recurrence ◽  
Surgical Procedures ◽  
Distant Metastasis ◽  
Spermatic Cord ◽  
High Ligation ◽  
History Of ◽  
Radical Orchiectomy

Paratesticularleiomyosarcomas are rare neoplasms. Radical orchidectomy and high ligation of cordfollowed by surveillance is the treatment of choice. Here we report a 73-year-old man who presentedwith a 2-year history of painless lump in the left hemiscrotum. A left radical orchiectomy with highligation of the spermatic cord was performed. The histo-pathological and immunohistochemistryevaluation revealed a moderately differentiated leiomyosarcoma of paratesticular region. Thepatient is still alive with no evidence of local recurrence and distant metastasis after seven years offollow-up._______________________________________________________________________________________Keywords: leiomyosarcoma; spermatic cord; paratesticular; surgical procedures.

Epithelioid sarcoma of the neck: case report

2009 ◽  
Vol 123 (S31) ◽  
pp. 113-116 ◽  
Author(s):  
Y Ueda ◽  
H Chijiwa ◽  
T Nakashima
Keyword(s):  
Case Report ◽  
Soft Tissue ◽  
Local Recurrence ◽  
Neck Dissection ◽  
Distant Metastasis ◽  
Epithelioid Sarcoma ◽  
Malignant Tumour ◽  
Final Diagnosis ◽  
History Of ◽  
Growing Mass

AbstractEpithelioid sarcoma is an aggressive, malignant tumour of the soft tissue which tends to arise in proximity to large tendons and aponeuroses. We report the case of a patient presenting with an epithelioid sarcoma arising in the neck. A 56-year-old man was referred with a three-year history of a sensory disorder as well as a slowly growing mass in his right neck. The patient underwent resection of the tumour by means of a conservative neck dissection. The final diagnosis, based on the histological and immunohistochemical findings, was epithelioid sarcoma. Radiotherapy was performed after the operation. The post-operative course was uneventful, and there was no local recurrence or distant metastasis.

scholarly journals Intraosseous Schwannoma (Neurilemmoma) of the Cervical Spine

Sarcoma ◽  
2001 ◽  
Vol 5 (2) ◽  
pp. 101-103 ◽  
Author(s):  
H. W. Bart Schreuder ◽  
René P. H. Veth ◽  
Maciej Pruszczynski ◽  
J. Albert M. Lemmens ◽  
Erik W. van Laarhoven
Keyword(s):  
Case Report ◽  
Cervical Spine ◽  
Local Recurrence ◽  
Review Of The Literature ◽  
Rare Tumour ◽  
Intraosseous Schwannoma ◽  
Long Term Follow Up

Purpose:To report on an extremely rare tumour located in the cervical spine, its treatment and result. Review of the literature.Patient:Case report of a 38-year-old woman with an intraosseous schwannoma of the cervical spine.Results:After local curettage no evidence for local recurrence at long-term follow-up.

scholarly journals Influence of Body Mass Index on Long-Term Outcome in Patients with Rectal Cancer—A Single Centre Experience

Cancers ◽  
2019 ◽  
Vol 11 (5) ◽  
pp. 609 ◽  
Author(s):  
Kalb ◽  
Langheinrich ◽  
Merkel ◽  
Krautz ◽  
Brunner ◽  
...  
Keyword(s):  
Body Mass Index ◽  
Rectal Cancer ◽  
Overall Survival ◽  
Local Recurrence ◽  
Distant Metastasis ◽  
Hazard Ratio ◽  
Term Outcome ◽  
Long Term Outcome ◽  
Obesity Class

Background: Excess bodyweight is known to influence the risk of colorectal cancer; however, little evidence exists for the influence of the body mass index (BMI) on the long-term outcome of patients with rectal cancer. Methods: We assessed the impact of the BMI on the risk of local recurrence, distant metastasis and overall—survival in 612 patients between 2003 and 2010 after rectal cancer diagnosis and treatment at the University Hospital Erlangen. A Cox-regression model was used to estimate the hazard ratio and multivariate risk of mortality and distant-metastasis. Median follow up-time was 58 months. Results: Patients with obesity class II or higher (BMI ≥ 35 kg/m2, n = 25) and patients with underweight (BMI < 18.5 kg/m2, n = 5) had reduced overall survival (hazard ratio (HR) = 1.6; 95% confidence interval (CI) 0.9–2.7) as well as higher rates of distant metastases (hazard ratio HR = 1.7; 95% CI 0.9–3.3) as compared to patients with normal bodyweight (18.5 ≤ BMI < 25 kg/m2, n = 209), overweight (25 ≤ BMI <30 kg/m2, n = 257) or obesity class I (30 ≤ BMI <35 kg/m2, n = 102). There were no significant differences for local recurrence. Conclusions: Underweight and excess bodyweight are associated with lower overall survival and higher rates of distant metastasis in patients with rectal cancer.

scholarly journals Giant Diaphragmatic Angiosarcoma of Adult: A Case Report and Review of Literature

2012 ◽  
Vol 2012 ◽  
pp. 1-3
Author(s):  
Tao Ren ◽  
Xue-qian Chen
Keyword(s):  
Case Report ◽  
Soft Tissue ◽  
Local Recurrence ◽  
Adult Patient ◽  
Distant Metastasis ◽  
Soft Tissue Tumor ◽  
Review Of Literature ◽  
Tissue Tumor ◽  
Malignant Soft Tissue Tumor ◽  
Malignant Soft Tissue

Angiosarcoma is a rare vascular malignant soft tissue tumor, with highly malignant, invasive, and multifocal characteristics of biology, which is prone to local recurrence and distant metastasis, so the prognosis is extremely poor. It rarely involves the diaphragm. We present the case of an adult patient who had a primary giant angiosarcoma of the left-sided diaphragm.

scholarly journals Polymorphous low grade adenocarcinoma in oral cavity: a case report

1970 ◽  
Vol 16 (1) ◽  
pp. 66-69
Author(s):  
Mostafa Mahfuzul Anwar ◽  
AKM Sahabuddin Khan
Keyword(s):  
Case Report ◽  
Oral Cavity ◽  
Distant Metastasis ◽  
Regional Lymph Node ◽  
Careful Examination ◽  
Low Grade ◽  
Adenoid Cystic ◽  
Slow Growing

Polymorphous low grade adenocarcinoma is a slow growing tumor mainly arises in minorsalivary glands in oral cavity. The frequency of regional lymph node and distant metastasis arevery low in this tumor. Careful examination of histolopathological specimen is necessary asfeatures frequently overlap with that of pleomorphic adenoma and adenoid cystic carcinoma.Local excision is the treatment of this condition. Recurrences and distant metastasis werereported in literature many years after surgery. So, long term regular follow up is required inthis group of patients.DOI: 10.3329/bjo.v16i1.5784Bangladesh J Otorhinolaryngol 2010; 16(1): 66-69

Pleomorphic adenoma of the nasal cavity – a case report

2020 ◽  
Vol 9 (2) ◽  
pp. 1-5
Author(s):  
Anna Frączek ◽  
Julia Szczygielska ◽  
Daniel Majszyk ◽  
Kazimierz Niemczyk
Keyword(s):  
Case Report ◽  
Local Recurrence ◽  
Nasal Cavity ◽  
Pleomorphic Adenoma ◽  
Potential Risk ◽  
Benign Tumor ◽  
Histopathological Examination ◽  
Lateral Nasal Wall ◽  
Adenoid Cystic

<b>Introduction: </b>Pleomorphic adenoma is a benign tumor which occurs most commonly in the major salivary glands. It is very rare in the nasal cavity and may be misdiagnosed because of its uncharacteristic clinical and histopathological manifestation. <br><b>Case report: </b>A case of a 42-year-old patient with pleomorphic adenoma on the lateral nasal wall has been presented. The tumor was accidentally found during FESS and septorhinoplasty. Initially, based on the histopathological examination of the obtained sample, there was a suspicion of adenoid cystic carcinoma. Later, the neoplasm was completely removed by the open septorhinoplasty and histopathological re-examination showed features of pleomorphic adenoma. Long term followup was necessary due to the potential risk of local recurrence.

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