scholarly journals Participation of Thrombospondin-1 in the Activation of Latent Transforming Growth Factor-.BETA. in Malignant Glioma Cells.

2001 ◽  
Vol 41 (5) ◽  
pp. 253-259 ◽  
Author(s):  
Atsushi SASAKI ◽  
Hirofumi NAGANUMA ◽  
Eiji SATOH ◽  
Tomoyuki KAWATAKI ◽  
Kenichi AMAGASAKI ◽  
...  
Keyword(s):  
Growth Factor ◽  
Malignant Glioma ◽  
Transforming Growth Factor Beta ◽  
Transforming Growth Factor ◽  
Glioma Cells ◽  
Thrombospondin 1 ◽  
Growth Factor Beta ◽  
Malignant Glioma Cells

scholarly journals P.106 Thrombospondin 1 mediates transforming growth factor beta induced premature senescence in primary glioblastoma cells

2016 ◽  
Vol 43 (S2) ◽  
pp. S45-S45
Author(s):  
R Kumar ◽  
I Lorimer
Keyword(s):  
Growth Factor ◽  
Transforming Growth Factor Beta ◽  
Molecular Mechanisms ◽  
Transforming Growth Factor ◽  
Global Gene Expression ◽  
Premature Senescence ◽  
Primary Glioblastoma ◽  
Thrombospondin 1 ◽  
Growth Factor Beta ◽  
Novel Therapeutic Strategies

Background: Glioblastoma is the most common primary malignant brain tumor. Primary Glioblastoma (PriGO) cells are key drivers of glioblastoma. Senescence is the irreversible growth arrest of cells with continued metabolic activity. Recently, I discovered PriGO cells undergo premature senescence in response to Fetal Bovine Serum (FBS). Determining the underlying molecular mechanisms may allow development of novel therapeutic strategies to decrease the malignant potential of glioblastoma. Methods: Global gene expression changes in PriGO cells treated with serum were analyzed and compared to untreated cells. Senescence was determined by the Senescence-Associated-Beta-Galactosidase (SA-B-Gal) assay. Results: PriGO cells treated with serum demonstrated increased expression of genes in the Transforming Growth Factor Beta (TGF-B) pathway, such as Thrombospondin 1 (TSP1), compared to untreated cells. TGF-B treatment of PriGO cells significantly increased senescence compared to untreated cells. Treatment of PriGO cells with serum and the TGF-B inhibitor SB431542 led to a decrease in senescence compared to serum only treated cells. Treatment of PriGO cells with serum and the TSP1 inhibitor LSKL led to a reduction in senescence compared to serum only treated cells. Conclusions: Our data identifies TGF-B as an important component of serum responsible for inducing senescence in PriGO cells. Furthermore, TGF-B induced senescence in PriGO cells is in part mediated by TSP1.

Correlation of thrombospondin-1 and transforming growth factor-beta expression with malignancy of glioma

2000 ◽  
Vol 20 (3) ◽  
pp. 161-169 ◽  
Author(s):  
Tomoyuki Kawataki ◽  
Hirofumi Naganuma ◽  
Atsushi Sasaki ◽  
Hideji Yoshikawa ◽  
Kachio Tasaka ◽  
...  
Keyword(s):  
Growth Factor ◽  
Transforming Growth Factor Beta ◽  
Transforming Growth Factor ◽  
Thrombospondin 1 ◽  
Growth Factor Beta

scholarly journals Modulation of Transforming Growth Factor-β Secretion from Malignant Glioma Cells by Interleukin-1β

1996 ◽  
Vol 36 (3) ◽  
pp. 145-150 ◽  
Author(s):  
Hirofumi NAGANUMA ◽  
Atsushi SASAKI ◽  
Eiji SATOH ◽  
Mitsuyasu NAGASAKA ◽  
Shin NAKANO ◽  
...  
Keyword(s):  
Growth Factor ◽  
Malignant Glioma ◽  
Transforming Growth Factor ◽  
Glioma Cells ◽  
Transforming Growth Factor Β ◽  
Interleukin 1Β ◽  
Malignant Glioma Cells
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