scholarly journals Modulation of Transforming Growth Factor-β Secretion from Malignant Glioma Cells by Interleukin-1β

1996 ◽  
Vol 36 (3) ◽  
pp. 145-150 ◽  
Author(s):  
Hirofumi NAGANUMA ◽  
Atsushi SASAKI ◽  
Eiji SATOH ◽  
Mitsuyasu NAGASAKA ◽  
Shin NAKANO ◽  
...  
Keyword(s):  
Growth Factor ◽  
Malignant Glioma ◽  
Transforming Growth Factor ◽  
Glioma Cells ◽  
Transforming Growth Factor Β ◽  
Interleukin 1Β ◽  
Malignant Glioma Cells

scholarly journals Participation of Thrombospondin-1 in the Activation of Latent Transforming Growth Factor-.BETA. in Malignant Glioma Cells.

2001 ◽  
Vol 41 (5) ◽  
pp. 253-259 ◽  
Author(s):  
Atsushi SASAKI ◽  
Hirofumi NAGANUMA ◽  
Eiji SATOH ◽  
Tomoyuki KAWATAKI ◽  
Kenichi AMAGASAKI ◽  
...  
Keyword(s):  
Growth Factor ◽  
Malignant Glioma ◽  
Transforming Growth Factor Beta ◽  
Transforming Growth Factor ◽  
Glioma Cells ◽  
Thrombospondin 1 ◽  
Growth Factor Beta ◽  
Malignant Glioma Cells

scholarly journals Secretion of Transforming Growth Factor-β1 and -β2 by Malignant Glioma Cells

1995 ◽  
Vol 35 (7) ◽  
pp. 423-430 ◽  
Author(s):  
Atsushi SASAKI ◽  
Hirofumi NAGANUMA ◽  
Eiji SATOH ◽  
Mitsuyasu NAGASAKA ◽  
Shiro ISOE ◽  
...  
Keyword(s):  
Growth Factor ◽  
Malignant Glioma ◽  
Transforming Growth Factor ◽  
Glioma Cells ◽  
Transforming Growth Factor Β1 ◽  
Malignant Glioma Cells

The effect of interleukin-1β and transforming growth factor β on cathepsin B activity in human articular chondrocytes

1994 ◽  
Vol 41 (S2) ◽  
pp. C198-C200 ◽  
Author(s):  
M. H. M. Meijers ◽  
C. M. Aisa ◽  
M. E. J. Billingham ◽  
R. G. G. Russell ◽  
R. A. D. Bunning
Keyword(s):  
Growth Factor ◽  
Cathepsin B ◽  
Transforming Growth Factor ◽  
Articular Chondrocytes ◽  
Transforming Growth Factor Β ◽  
Interleukin 1Β ◽  
Human Articular Chondrocytes

Interaction of acidic fibroblast growth factor and transforming growth factor-β in normal and transformed glia in vitro

1992 ◽  
Vol 76 (5) ◽  
pp. 850-855 ◽  
Author(s):  
Timothy C. Ryken ◽  
Vincent C. Traynelis ◽  
Ramon Lim
Keyword(s):  
Growth Factor ◽  
Mitotic Activity ◽  
Transforming Growth Factor ◽  
Morphological Changes ◽  
Glioma Cells ◽  
Transforming Growth Factor Β ◽  
Acidic Fibroblast Growth Factor ◽  
Fetal Rat ◽  
Rat Astrocytes

✓ The mitogenic and morphological effects of acidic fibroblast growth factor (aFGF) and transforming growth factor-β (TGF-β) were assessed on cultured fetal rat astrocytes and C6 rat glioma cells in the presence and absence of serum. Astrocytes incubated with aFGF exhibited an increase in mitotic activity and characteristic morphological changes involving extensive process formation and rounding of cell bodies. Astrocytes incubated with TGF-β underwent a slight decrease in mitotic activity and remained morphologically unchanged. Cells exposed to a combination of aFGF and TGF-β demonstrated an attenuation of both the mitogenic and morphological changes observed in the presence of aFGF alone. The C6 glioma cells cultured in the presence of aFGF underwent a characteristic morphological change from a rounded piling cell mass to a more spindle-shaped bipolar cell layer, accompanied by an increase in mitotic activity. In contrast to the astrocyte cultures, increased growth and similar morphological effects were produced by TGF-β. The combination of aFGF and TGF-β did not result in attenuation of the mitogenic and morphological changes (as seen in astrocytic cells). These results suggest that, in normal fetal rat astrocytes, TGF-β is capable of attenuating the mitogenic and morphological changes induced by aFGF in vitro. In the transformed C6 glioma cell line, aFGF and TGF-β elicit similar mitogenic and morphological changes, without evidence of an antagonistic interaction as seen in normal astrocytes.

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