scholarly journals Local Cerebral Blood Flow and Glucose Metabolism in Hydrostatic Brain Edema

1993 ◽  
Vol 33 (3) ◽  
pp. 139-145 ◽  
Author(s):  
Hitoshi UMEZAWA ◽  
Katsuji SHIMA ◽  
Hiroo CHIGASAKI ◽  
Shozo ISHII
Keyword(s):  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Glucose Metabolism ◽  
Brain Edema ◽  
Local Cerebral Blood Flow

scholarly journals Influence of early posttraumatic hypothermia therapy on local cerebral blood flow and glucose metabolism after fluid-percussion brain injury

2001 ◽  
Vol 11 (4) ◽  
pp. 510-519
Author(s):  
Weizhao Zhao ◽  
Ofelia F. Alonso ◽  
Judith Y. Loor ◽  
Raul Busto ◽  
Myron D. Ginsberg
Keyword(s):  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Glucose Metabolism ◽  
Glucose Utilization ◽  
Linear Regression Analysis ◽  
Data Sets ◽  
Imaging Data ◽  
Local Cerebral Blood Flow ◽  
Fluid Percussion ◽  
The Right

Object Using autoradiographic image averaging, the authors recently described prominent foci of marked glucose metabolism-greater-than-blood-flow uncoupling in the acutely traumatized rat brain. Because hypothermia is known to ameliorate injury in this and other injury models, the authors designed the present study to assess the effects of post-traumatic therapeutic hypothermia on the local cerebral metabolic rate of glucose (LCMRglu) and local cerebral blood flow (LCBF) following moderate parasagittal fluid-percussion head injury (FPI) in rats. Methods Either cranial hypothermia (30°C) or normothermia (37°C) was induced for 3 hours in matched groups of rats immediately after FPI; LCMRglu and LCBF were assessed 3 hours after concluding these temperature manipulations. In rats subjected to FPI, regardless of whether normothermia or hypothermia ensued, LCBF was reduced relative to the sham-injury groups. In addition, when FPI was followed by hypothermia (FPI–30°C group), the subsequent LCBF was significantly lower (35–38% on average) than in FPI–37°C rats. Statistical mapping of LCBF difference imaging data revealed confluent cortical and subcortical zones of significantly reduced LCBF (largely ipsilateral to the prior injury) in FPI–30°C rats relative to the FPI–37°C group. Local glucose utilization was reduced in both hemispheres of FPI–37°C rats relative to the sham-injury group and was lower in the right (traumatized) hemisphere than in the left. However, LCMRglu values were largely unaffected by temperature manipulation in either the FPI or sham-injury groups. The LCMRglu/LCBF ratio was nearly doubled in FPI–30°C rats relative to the FPI–37°C group, in a diffuse and bihemispheric fashion. Linear regression analysis comparing LCMRglu and LCBF revealed that the FPI–37°C and FPI–30°C data sets were completely nonoverlapping, whereas the two sham-injury data sets were intermixed. Conclusions Despite its proven neuroprotective efficacy, early posttraumatic hypothermia (30°C for 3 hours) nonetheless induces a moderate decline in cerebral perfusion without the (anticipated) improvement in cerebral glucose utilization, so that a state of mild metabolism-greater-than-blood-flow dissociation is perpetuated.

Local Cerebral Blood Flow and Glucose Metabolism in Hydrostatic Brain Oedema

1990 ◽  
pp. 351-353
Author(s):  
H. Umezawa ◽  
K. Shima ◽  
H. Chigasaki ◽  
K. Sato ◽  
S. Ishii
Keyword(s):  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Glucose Metabolism ◽  
Brain Oedema ◽  
Local Cerebral Blood Flow

scholarly journals Evaluation of a Double-Tracer Autoradiographic Technique for the Measurement of Both Local Cerebral Glucose Metabolism and Local Cerebral Blood Flow

1985 ◽  
Vol 5 (2) ◽  
pp. 335-337 ◽  
Author(s):  
Stephen C. Jones ◽  
Joel H. Greenberg
Keyword(s):  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Glucose Metabolism ◽  
Brain Tissue ◽  
Simultaneous Measurement ◽  
Cerebral Glucose Metabolism ◽  
Careful Attention ◽  
Local Cerebral Blood Flow ◽  
Tissue Sections ◽  
Autoradiographic Technique

A solvent washout technique is evaluated that could be used to remove one 14C tracer after a combined autoradiographic CMRglu and CBF study using [14C]2-deoxyglucose (2DG) and [14C]iodoantipyrine (IAP). The technique permits the simultaneous measurement of local CBF and local CMRglu in the same animal without the use of the short-lived tracers of iodine, 123I and 131I, for iodoantipyrine labeling. This report shows that brain tissue sections did not retain 14C from [14C]2DG when chloroform was used as the washout solvent. Chloroform washing removes nearly all the 14C from [14C]IAP. For this study, careful attention was given to the control, pre-wash measurement of 14C concentration.

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