Examination of an efficient extraction method for rice-bran albumin and its suppressive effect on postprandial blood glucose elevation

2021 ◽  
Author(s):  
Rio Ogawa ◽  
Sunao Kotani ◽  
Kazumi Ninomiya ◽  
Shigenobu Ina ◽  
Hitoshi Kumagai ◽  
...  
Keyword(s):  
Blood Glucose ◽  
Rice Bran ◽  
Extraction Method ◽  
Suppressive Effect ◽  
Postprandial Blood Glucose ◽  
Efficient Extraction ◽  
Blood Glucose Elevation ◽  
Rice Bran Albumin

scholarly journals Suppressive Effect of the α-Amylase Inhibitor Albumin from Buckwheat (Fagopyrum esculentum Moench) on Postprandial Hyperglycaemia

Nutrients ◽  
2018 ◽  
Vol 10 (10) ◽  
pp. 1503 ◽  
Author(s):  
Kazumi Ninomiya ◽  
Shigenobu Ina ◽  
Aya Hamada ◽  
Yusuke Yamaguchi ◽  
Makoto Akao ◽  
...  
Keyword(s):  
Blood Glucose ◽  
Competitive Inhibition ◽  
Suppressive Effect ◽  
Postprandial Blood Glucose ◽  
Amylase Inhibitor ◽  
Level Elevation ◽  
Fagopyrum Esculentum Moench ◽  
Blood Glucose Elevation

Inhibiting starch hydrolysis into sugar could reduce postprandial blood glucose elevation and contribute to diabetes prevention. Here, both buckwheat and wheat albumin that inhibited mammalian α-amylase in vitro suppressed blood glucose level elevation after starch loading in vivo, but it had no effect after glucose loading. In contrast to the non-competitive inhibition of wheat α-amylase inhibitor, buckwheat albumin acted in a competitive manner. Although buckwheat α-amylase inhibitor was readily hydrolysed by digestive enzymes, the hydrolysate retained inhibitory activity. Together with its thermal stability, this suggests its potential use in functional foods that prevent diabetes.

scholarly journals Suppressive effect of a single dose of monoglucosyl rutin on postprandial blood glucose elevation: A randomized, placebo-controlled, double-blind crossover study

2021 ◽  
Vol 11 (6) ◽  
pp. 270
Author(s):  
Yushi Hashizume ◽  
Mahamadou Tandia
Keyword(s):  
Blood Glucose ◽  
Crossover Study ◽  
Fasting Blood Glucose ◽  
Area Under The Curve ◽  
Suppressive Effect ◽  
Postprandial Blood Glucose ◽  
Double Blind ◽  
Blood Glucose Elevation ◽  
Blind Crossover Study ◽  
Double Blind Crossover Study

Objective: This study aimed to investigate the suppressive effect of a single dose of water-soluble α- glycosylated rutin (monoglucosyl rutin; MR) on postprandial blood glucose elevation in healthy subjects with relatively high fasting blood glucose levels.Methods: This randomized, placebo-controlled, double-blind crossover study enrolled 34 healthy Japanese adult subjects with relatively high fasting blood glucose levels. The study period ran from November 13, 2019, to March 19, 2020. All subjects were randomly allocated to either sequence A or sequence B (n = 17 per group) using a computerized random number generator. The washout period was at least one week between periods I and II. In period I, the subjects took either MR or placebo tablets. In period II, subjects took different tablets from the ones they had taken in period I. We evaluated their blood glucose and insulin levels after glucose loading (150 g of cooked rice). The incremental area under the curve (IAUC) of the postprandial blood glucose level was determined as the primary outcome. The blood glucose and insulin levels at maximum (maximum blood concentration; Cmax), each measurement point, and IAUC of the blood insulin level after glucose loading were the secondary outcomes.Results: Out of 33 subjects, 16 in sequence A (11 men and 5 women, 54.5 ± 9.8 years) and 17 in sequence B (9 men and 8 women, 58.8 ± 9.4 years) were analyzed as a per-protocol dataset. The glucose IAUC after MR consumption was significantly lower than that of the placebo (P = 0.034). Results of the other outcomes were not observed with significant treatment effects. There were no adverse events attributable to the test foods.Conclusions: We suggest that MR has a suppressive effect on the elevation of postprandial blood glucose in healthy adults with relatively high fasting blood glucose levels.Trial registration: UMIN-CTR: UMIN000038515. Foundation: Toyo Sugar Refining Co., Ltd.Keywords: monoglucosyl rutin, blood glucose level, incremental area under the curve, α-amylase, α-glucosidase, crossover study

Skin-related enzyme inhibitory activity by hydrolyzable polyphenols in water chestnut (Trapa natans) husk

2021 ◽  
Vol 85 (3) ◽  
pp. 666-674
Author(s):  
Midori Yasuda ◽  
Masaki Ikeoka ◽  
Shin-ichi Kondo
Keyword(s):  
Suppressive Effect ◽  
Postprandial Blood Glucose ◽  
Water Chestnut ◽  
Trapa Natans ◽  
Related Enzyme ◽  
Inhibitory Activities ◽  
Blood Glucose Elevation ◽  
Lifestyle Related Diseases ◽  
The Devil ◽  
Floating Leaf

ABSTRACT Water chestnut is a floating leaf plant native to Asia and Europe. Its fruit has long been used as an edible and herbal medicine. Water chestnut contains many polyphenols and its consumption can prevent lifestyle-related diseases because it has a suppressive effect on postprandial blood glucose elevation; however, its suitability as a cosmetic material is unknown. Therefore, this study aimed at investigating the antiaging effect of polyphenols contained in the husk of the devil water chestnut (Trapa natans). Six hydrolyzable polyphenols—1,6-di-O-galloyl-β-d-glucopyranose, 1,2,6-tri-O-galloyl-β-d-glucopyranose, 1,6-di-O-galloyl-2,3-O-(S)-hexahydroxydiphenoyl-β-d-glucopyranose (nobotanin D), eugeniin, 1,2,3,6-tetra-O-galloyl-β-d-glucopyranose, and trapain—were collected and isolated from the water chestnut husk. These polyphenols showed high antioxidant and antiglycation activities. In addition, inhibitory activities against hyaluronidase, elastase, and collagenase were observed. Especially, eugeniin and trapain, which have many gallic acids and a hexahydroxy-biphenyl group, showed high inhibitory activities. Thus, the polyphenols in water chestnut are beneficial for antiaging effects.

scholarly journals Rice Bran Oil Compared to Atorvastatin for Treatment of Dyslipidemia in Patients with Type 2 Diabetes

2014 ◽  
Vol 2 (1) ◽  
pp. 95-102 ◽  
Author(s):  
Marie-Christine Shakib ◽  
Shreef Gabrial ◽  
Gamal Gabrial
Keyword(s):  
Type 2 Diabetes ◽  
Blood Glucose ◽  
Rice Bran ◽  
Serum Lipid ◽  
Rice Bran Oil ◽  
Glycosylated Hemoglobin ◽  
Postprandial Blood Glucose ◽  
Atorvastatin Group ◽  
Calorie Diet

Objective: To compare the effect of rice bran oil versus statins (atorvastatin drug) on blood glucose, glycosylated hemoglobin (HbA1C) and serum lipid profiles in patients with type 2 diabetes. The safety of the tested rice bran oil and atorvastatin were investigated. Fatty acids contents of RBO, olive and sesame oil were also assessed.Materials and Methods: Forty four eligible patients with type 2 diabetes and moderately hyperlipidemic were randomly and equally allocated into two groups, rice bran oil (RBO) group and atorvastatin group. The RBO group received a low-calorie diet and consumed 30 g / day RBO oil as salad dressing and for use as main cooking oil for 6 months. The Atorvastatin group received a low-calorie diet and 40 mg/day of atorvastatin drug for 6 months. At baseline and after 6 months of study intervention, blood glucose, glycosylated hemoglobin (HbA1c), serum lipid profiles; hepatic, renal and inflammatory biomarkers were estimated.Results: Results showed significant increase in fasting and postprandial blood glucose, HbA1C and liver transaminases (alanine transaminase ALT and aspartate transaminase AST) in the atorvastatin group while a significant reduction was shown in RBO group. Moreover, significant reductions in lipid profile levels, blood urea, serum uric acid and erythrocyte sedimentation rate (ESR) were observed in both RBO and atorvastatin groups after 6 months of the study intervention.Conclusion: The use of rice bran oil together with dietary modifications may have implications in lowering fasting and postprandial blood glucose, suppressing serum lipid levels, reduce the TC/HDL-C ratio and therefore reducing the risk of cardiovascular disease. Moreover, RBO exerts a hypouricemic action and anti-inflammatory effects. The findings obtained from the current study reinforce the use of RBO as an alternative natural potent hypolipidemic agent safer than atorvastatin drug that may induce side effects in some cases in patients intolerant to statins.

scholarly journals Effect of Siraita grosvenori on postprandial blood glucose elevation in human

2018 ◽  
Vol WCP2018 (0) ◽  
pp. PO4-8-9
Author(s):  
Aki Ogawa ◽  
Sayaka Yoshida ◽  
Takahito Ichi ◽  
Rikako Inoue ◽  
Maya Tsumagari ◽  
...  
Keyword(s):  
Blood Glucose ◽  
Postprandial Blood Glucose ◽  
Blood Glucose Elevation
Sign in / Sign up

Export Citation Format

Share Document