Study of lipid profile, enzymatic antioxidant and oxidative stress in cardiovascular diseases

2016 ◽  
Vol 5 (08) ◽  
pp. 4759
Author(s):  
Binod Mahato
Keyword(s):  
Oxidative Stress ◽  
Cardiovascular Diseases ◽  
Lipid Profile ◽  
Mean Values ◽  
Enzymatic Antioxidant ◽  
Medical College ◽  
Stress Markers ◽  
Antioxidant Enzymes Activities ◽  
The Mean ◽  
And Oxidative Stress

Cardiovascular disease is one of the major causes of death in the India, therefore present study, was aimed to study the lipid profile, enzymatic antioxidant and oxidative stress in cardiovascular diseases. The study was carried out in the Department of Biochemistry and Medicine MGM Medical College and Hospital, Mumbai. 5ml. Blood sample was drawn into plain vacutainers and was utilised for estimation of lipid profile, oxidative stress markers concentration and antioxidant enzymes activities. The mean values of Total cholesterol, LDL TG, and MDA were significantly increased in CVD patients as compared to control (p<0.0001) and HDL, NO, SOD, CAT in CVD patients were significantly decreased as compared to control (p<0.0001). The present study reveals the importance of determining the lipid profile, free radicals and antioxidant status in CVD to enable the formulation of specific therapies for early intervention and better management of disease.

scholarly journals EVALUATION OF BIOCHEMICAL AND OXIDATIVE STRESS MARKERS AS PREDICTIVE TOOL FOR DIAGNOSIS OF BIRTH ASPHYXIA AND ENCEPHALOPATHY IN NEW BORN

2021 ◽  
Vol 9 (10) ◽  
pp. 891-897
Author(s):  
Shweta Singh ◽  
◽  
Babita Singhal ◽  
Bhumika Upadhyay ◽  
Chandra Mohan Kumar ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Cord Blood ◽  
Umbilical Cord Blood ◽  
Apgar Score ◽  
Oxidative Stress Markers ◽  
Term Neonates ◽  
Mean Values ◽  
Stress Markers ◽  
The Mean ◽  
And Oxidative Stress

Background:Birth asphyxia and resultanthypoxic ischemic encephalopathy (HIE), are leading cause of mortality and morbidity in newborns. Delayed diagnosis may lead to progression of HIE as its clinical features may not be evident at birth as they evolve with time. This study was done to identify asphyxia and HIE in term neonates by evaluating biochemical and oxidative stress markers in umbilical cord blood sample taken immediately after delivery. Methodology: This prospective cross sectional study was done on term neonates in a tertiary care hospital (n=60)Thestudy population was then divided into two equal groups on the basis of Apgar score at 1 minute, with score < 7 as cases (n=30) and ≥7 as controls ( n=30) . The umbilical cord blood was evaluated for biochemical and oxidative stress markers like lactate dehydrogenase (LDH), creatine kinase brain isoform (CK BB), superoxide dismutase (SOD,malondialdehyde (MDH) and catalase. Result: The mean values of LDH, CK BB, and MDA were higher in cases than controls and the differences were highly significant statistically. The mean values of SOD and catalase were higher in cases than controls and the differences were significant statistically. However, mean value of LDH & CKBB of cases with prolonged asphyxia with Apgar score < 7 at 5 minutes (n=4) versus cases with Apgar score > 7 (n=26) was not statistically significant at 95% CI. Conclusion: This study helps in diagnosis of neonatal asphyxia at an early stage thereby preserving the normal functioning of neonatal brain so that the brain functioning is not compromised.

scholarly journals Decreased Lipid Profile and Oxidative Stress in Healthy Subjects Who Underwent Whole-Body Cryotherapy in Closed Cryochamber with Subsequent Kinesiotherapy

2019 ◽  
Vol 2019 ◽  
pp. 1-10 ◽  
Author(s):  
Agata Stanek ◽  
Ewa Romuk ◽  
Tomasz Wielkoszyński ◽  
Stanisław Bartuś ◽  
Grzegorz Cieślar ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Lipid Profile ◽  
Healthy Subjects ◽  
Whole Body ◽  
Stress Index ◽  
Stress Markers ◽  
Total Antioxidant ◽  
Whole Body Cryotherapy ◽  
The Impact ◽  
And Oxidative Stress

Objective. The aim of the study was to estimate the impact of whole-body cryotherapy (WBC) and subsequent kinesiotherapy on oxidative stress and lipid profile when performed in a closed cryochamber on healthy subjects. Material and Methods. The effect of ten WBC procedures lasting 3 minutes a day followed by a 60-minute session kinesiotherapy on oxidative stress and lipid profile in healthy subjects (WBC group, n=16) was investigated. The WBC group was compared to the kinesiotherapy only (KT; n=16) group. The routine parameters of oxidative stress (antioxidant enzymatic and nonenzymatic antioxidant status, lipid peroxidation products, total oxidative status (TOS), and oxidative stress index (OSI)) and lipid profile were estimated one day before the beginning and one day after the completion of the research program. Results. After treatment, in the WBC group, a significant decrease of oxidative stress markers (TOS and OSI) and a significant increase of total antioxidant capacity were observed. The activity of plasma SOD-Mn and erythrocyte total SOD increased significantly in the WBC group. In the KT group, the erythrocyte activity of total SOD, CAT, and GR decreased significantly after the treatment. The levels of T-Chol and LDL-Chol decreased significantly after treatment in both groups, but the observed decrease of these lipid parameters in the WBC group was higher in comparison to the KT group. The level of TG decreased significantly after treatment in the WBC group only. Conclusion. WBC performed in a closed cryochamber followed by kinesiotherapy improves lipid profile and decreases oxidative stress in healthy subjects.

scholarly journals A Comparison of the Effect of Chamomile Tea and Black Tea Consumption on Depression and Oxidative Stress Markers in Depressed Patients with Type II Diabetes: a Randomized Clinical Trial

2018 ◽  
Author(s):  
Sahar Kermanian ◽  
Hassan Mozaffari-Khosravi ◽  
Javad Zavar Reza ◽  
Ghasem Dastgerdi ◽  
Mohammadhasan Lotfi
Keyword(s):  
Oxidative Stress ◽  
Clinical Trial ◽  
Randomized Clinical Trial ◽  
Black Tea ◽  
The Public ◽  
Depressed Patients ◽  
Stress Markers ◽  
Patients With Diabetes ◽  
The Mean ◽  
And Oxidative Stress

Introduction: According to the Public Beliefs and Chamomile combinations based on its relief effect, this trial is done to compare the effects of chamomile tea and black tea on depression and oxidative stress in depressed patients with diabetes. Methods: This is a randomized clinical trial that was done with participation of 74 depressed patients with diabetes. Participants were randomly divided to two groups of chamomile tea (CG) and black tea (BG) (n=37), that received 3 daily cups of chamomile tea and black tea bags respectively, at least half an hour after meals. Beck Depression Inventory was completed to assess depression at baseline, after 6 and 12 weeks. TAC and MDA tests were done at the beginning and end of the study. Results: At the end of study, 64 patients completed the study. After the study, mean scores of beck decreased significantly between the two groups. Beck scores showed significant differences in both CG (P < 0.001) and BG (P = 0.04) after the intervention, but the mean changes in scores were Obtained significantly in CG more than BG. Mean TAC was significantly decreased in both CG and BG, the mean changes showed no significant differences between the two groups. Conclusion: This study showed that consumption of chamomile tea compared with black tea relatively decreased depression, but had no significant effects on oxidative stress.

scholarly journals ASSESSMENT OF SERUM LIPID PROFILE IN HYPERTENSIVE PATIENTS: A CASE-CONTROL STUDY

2020 ◽  
pp. 21-24
Author(s):  
Sushma Reddy V ◽  
Hari Prasad TV ◽  
Surendra B V
Keyword(s):  
Cardiovascular Diseases ◽  
Lipid Profile ◽  
Total Cholesterol ◽  
Serum Lipid ◽  
Ldl Cholesterol ◽  
Colorimetric Method ◽  
Serum Lipid Profile ◽  
Hypertensive Patients ◽  
Mean Values ◽  
The Mean

Background: Hypertension and dyslipidemia are strongly associated with each other, and they are the most common risk factors for the development of the cardiovascular disease. Aim: Compare the serum lipid profile values among hypertensive patients and non-hypertensive individuals. Method: 30 patients with Hypertension and 30 age-matched non-hypertensive controls were included in the study. From the serum, total cholesterol levels were estimated by enzymatic (CHOD-PAP) colorimetric method, triglyceride by enzymatic (GPO-PAP) method, HDL-cholesterol and LDL-cholesterol were estimated using precipitant and Friedewald formula, by using commercially available reagent kits. Lipid profiles were compared with controls. Results: The mean values of total cholesterol were significantly more in Hypertensives-202.93 ± 28.44 and normotensives-178.76 ± 37.21, P<0.006. The mean values of triglycerides were significantly more in Hypertensives-139.8 ± 18.72 and normotensives-125.8± 12.34, P<0.001. The mean values of LDL-Cholesterol were significantly more in Hypertensives-141.63 ± 11.59 and normotensives-127.83 ± 14.65, P<0.0001. Conclusions: As Dyslipidemia is associated with Hypertension, serum lipid profile may be useful in the identification of patients at risk of Hypertension. Hypertensive patients need the measurement of blood pressure and lipid profile at regular intervals to prevent Cardiovascular diseases. Keywords: Cholesterol; Cardiovascular Diseases; Hypertension; Triglycerides; Dyslipidemia.

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