scholarly journals EVALUATION OF BIOCHEMICAL AND OXIDATIVE STRESS MARKERS AS PREDICTIVE TOOL FOR DIAGNOSIS OF BIRTH ASPHYXIA AND ENCEPHALOPATHY IN NEW BORN

2021 ◽  
Vol 9 (10) ◽  
pp. 891-897
Author(s):  
Shweta Singh ◽  
◽  
Babita Singhal ◽  
Bhumika Upadhyay ◽  
Chandra Mohan Kumar ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Cord Blood ◽  
Umbilical Cord Blood ◽  
Apgar Score ◽  
Oxidative Stress Markers ◽  
Term Neonates ◽  
Mean Values ◽  
Stress Markers ◽  
The Mean ◽  
And Oxidative Stress

Background:Birth asphyxia and resultanthypoxic ischemic encephalopathy (HIE), are leading cause of mortality and morbidity in newborns. Delayed diagnosis may lead to progression of HIE as its clinical features may not be evident at birth as they evolve with time. This study was done to identify asphyxia and HIE in term neonates by evaluating biochemical and oxidative stress markers in umbilical cord blood sample taken immediately after delivery. Methodology: This prospective cross sectional study was done on term neonates in a tertiary care hospital (n=60)Thestudy population was then divided into two equal groups on the basis of Apgar score at 1 minute, with score < 7 as cases (n=30) and ≥7 as controls ( n=30) . The umbilical cord blood was evaluated for biochemical and oxidative stress markers like lactate dehydrogenase (LDH), creatine kinase brain isoform (CK BB), superoxide dismutase (SOD,malondialdehyde (MDH) and catalase. Result: The mean values of LDH, CK BB, and MDA were higher in cases than controls and the differences were highly significant statistically. The mean values of SOD and catalase were higher in cases than controls and the differences were significant statistically. However, mean value of LDH & CKBB of cases with prolonged asphyxia with Apgar score < 7 at 5 minutes (n=4) versus cases with Apgar score > 7 (n=26) was not statistically significant at 95% CI. Conclusion: This study helps in diagnosis of neonatal asphyxia at an early stage thereby preserving the normal functioning of neonatal brain so that the brain functioning is not compromised.

scholarly journals Comparison of oxidative stress markers in umbilical cord blood after vaginal and cesarean delivery

2014 ◽  
Vol 57 (2) ◽  
pp. 109 ◽  
Author(s):  
Eun Ji Noh ◽  
Yoon Ha Kim ◽  
Moon Kyoung Cho ◽  
Jong Woon Kim ◽  
Jin Wook Kim ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Cord Blood ◽  
Cesarean Delivery ◽  
Umbilical Cord ◽  
Umbilical Cord Blood ◽  
Oxidative Stress Markers ◽  
Stress Markers

Analysis of Oxidative Stress Markers in Glucose-6-Phoshate Dehydrogenase Deficient Umbilical Cord Blood Samples in Kampala, Uganda

PEDIATRICS ◽  
2016 ◽  
Vol 137 (Supplement 3) ◽  
pp. 392A-392A
Author(s):  
Paul S. Stadem ◽  
Megan Hilgers ◽  
Derrick Bengo ◽  
Susan Nabadda-Ndidde ◽  
Troy Lund
Keyword(s):  
Oxidative Stress ◽  
Cord Blood ◽  
Umbilical Cord ◽  
Umbilical Cord Blood ◽  
Oxidative Stress Markers ◽  
Blood Samples ◽  
Stress Markers

Study of lipid profile, enzymatic antioxidant and oxidative stress in cardiovascular diseases

2016 ◽  
Vol 5 (08) ◽  
pp. 4759
Author(s):  
Binod Mahato
Keyword(s):  
Oxidative Stress ◽  
Cardiovascular Diseases ◽  
Lipid Profile ◽  
Mean Values ◽  
Enzymatic Antioxidant ◽  
Medical College ◽  
Stress Markers ◽  
Antioxidant Enzymes Activities ◽  
The Mean ◽  
And Oxidative Stress

Cardiovascular disease is one of the major causes of death in the India, therefore present study, was aimed to study the lipid profile, enzymatic antioxidant and oxidative stress in cardiovascular diseases. The study was carried out in the Department of Biochemistry and Medicine MGM Medical College and Hospital, Mumbai. 5ml. Blood sample was drawn into plain vacutainers and was utilised for estimation of lipid profile, oxidative stress markers concentration and antioxidant enzymes activities. The mean values of Total cholesterol, LDL TG, and MDA were significantly increased in CVD patients as compared to control (p<0.0001) and HDL, NO, SOD, CAT in CVD patients were significantly decreased as compared to control (p<0.0001). The present study reveals the importance of determining the lipid profile, free radicals and antioxidant status in CVD to enable the formulation of specific therapies for early intervention and better management of disease.

Comparison of Salivary Antioxidants and Oxidative Stress Status in Gestational Diabetes Mellitus and Healthy Pregnant Women

2020 ◽  
Vol 20 ◽  
Author(s):  
Fatemeh Ahmadi-Motamayel ◽  
Shima Fathi ◽  
Mohammad Taghi Goodarzi ◽  
Shiva Borzouei ◽  
Jalal Poorolajal ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Diabetes Mellitus ◽  
Gestational Diabetes ◽  
Pregnant Women ◽  
Oxidative Stress Markers ◽  
Blood Samples ◽  
Stress Markers ◽  
Total Antioxidant ◽  
Total Oxidative Stress ◽  
And Oxidative Stress

Background: One of the most common complications of pregnant women is gestational diabetes mellitus (GDM). Oxidative stress can play an important role in GDM. Objective: The aim of this study was to evaluate salivary antioxidants and oxidative stress markers in GDM. Method: Twenty pregnant women with GDM and 20 healthy pregnant women with normal blood glucose test participated in this study. Five mL of unstimulated saliva samples were collected. Spectrophotometric assay was carried out for sialochemical analysis. Stata software was used for data analysis. Results: The GDM group exhibited no significant difference in salivary total antioxidant capacity and malondialdehyde compared to the healthy control group. All of antioxidants markers, the uric acid, total antioxidant, peroxidase and catalase, decreased in GDM group that the difference of peroxidase and catalase was statistically significant. All of oxidative stress markers, the salivary malondyaldehid, total oxidative stress and total thiol, increased in GDM group. GDM group exhibited significantly higher salivary total oxidative stress levels. Conclusion: Catalase level was significantly lower and total oxidative stress was significantly higher. These two markers might have significant importance and might exhibit early changes compared to other factors in GDM. . Some of salivary antioxidants might have diagnostic, prognostic or therapeutic implications in GDM. Other studies with large sample size on salivary and blood samples need to be done to confirm this properties and salivary samples using instead of blood samples in GDM biomarkers changes.

Evaluation of Salivary Antioxidants and Oxidative Stress Markers in Type 2 Diabetes Mellitus: A Retrospective Cohort Study

2020 ◽  
Vol 20 (4) ◽  
pp. 584-590 ◽  
Author(s):  
Shima Fathi ◽  
Shiva Borzouei ◽  
Mohammad Taghi Goodarzi ◽  
Jalal Poorolajal ◽  
Fatemeh Ahmadi-Motamayel
Keyword(s):  
Oxidative Stress ◽  
Diabetes Mellitus ◽  
Control Group ◽  
Oxidative Stress Markers ◽  
Stress Markers ◽  
Type 2 Dm ◽  
Patients With Diabetes ◽  
The Difference ◽  
And Oxidative Stress

Background: Diabetes Mellitus (DM) is a progressive metabolic disorder. Objective: The aim of this study was to investigate the relationship between antioxidant and oxidative stress markers in the saliva of patients with type 2 DM and a healthy control group. Methods: In this study, 20 patients with diabetes and 20 healthy individuals were evaluated. Salivary antioxidants markers consisted of total antioxidant capacity (TAC), uric acid (UA), peroxidase and catalase. Oxidative stress markers included total oxidant status (TOS), malondealdehyde (MDA) and total thiol (SH). Sialochemical analysis was performed with spectrophotometric assay. All the statistical analyses were conducted using STATA software. Results: TAC decreased significantly in patients with diabetes. Although salivary UA and peroxidase were lower in patients with diabetes compared to the control group, the difference was not significant. Salivary catalase in patients with diabetes was significantly lower than that in the control group. MDA and TOS exhibited significantly higher levels in type 2 DM. SH levels were slightly higher in DM. Conclusions: According to the results of the present study, there were some changes in the salivary levels of some antioxidants and oxidative stress markers in patients with type 2 DM and could be measured as an indicator of serum changes..

Minocycline effects on cerebral edema: Relations with inflammatory and oxidative stress markers following traumatic brain injury in mice

2009 ◽  
Vol 1291 ◽  
pp. 122-132 ◽  
Author(s):  
Shadi Homsi ◽  
Fabiola Federico ◽  
Nicole Croci ◽  
Bruno Palmier ◽  
Michel Plotkine ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Traumatic Brain Injury ◽  
Brain Injury ◽  
Cerebral Edema ◽  
Oxidative Stress Markers ◽  
Stress Markers ◽  
And Oxidative Stress
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