scholarly journals The Chick Embryo Chorioallantoic Membrane as a Model for in vivo Research on Anti-Angiogenesis

2000 ◽  
Vol 1 (1) ◽  
pp. 73-82 ◽  
Author(s):  
Domenico Ribatti ◽  
Angelo Vacca ◽  
Luisa Roncali ◽  
Franco Dammacco
Keyword(s):  
Chick Embryo ◽  
Chorioallantoic Membrane ◽  
Chick Embryo Chorioallantoic Membrane

The Chick Embryo Chorioallantoic Membrane as an in vivo Wound Healing Model

1996 ◽  
Vol 192 (10) ◽  
pp. 1068-1076 ◽  
Author(s):  
D. Ribatti ◽  
A. Vacca ◽  
G. Ranieri ◽  
S. Sorino ◽  
L. Roncali
Keyword(s):  
Wound Healing ◽  
Chick Embryo ◽  
Chorioallantoic Membrane ◽  
Chick Embryo Chorioallantoic Membrane ◽  
Wound Healing Model ◽  
Healing Model

scholarly journals In vivo time-course of the angiogenic response induced by multiple myeloma plasma cells in the chick embryo chorioallantoic membrane

2003 ◽  
Vol 203 (3) ◽  
pp. 323-328 ◽  
Author(s):  
Domenico Ribatti ◽  
Giuseppe De Falco ◽  
Beatrice Nico ◽  
Roberto Ria ◽  
Enrico Crivellato ◽  
...  
Keyword(s):  
Multiple Myeloma ◽  
Chick Embryo ◽  
Time Course ◽  
Plasma Cells ◽  
Chorioallantoic Membrane ◽  
Angiogenic Response ◽  
Chick Embryo Chorioallantoic Membrane

scholarly journals Ring-Fused Diphenylchlorins as Potent Photosensitizers for Photodynamic Therapy Applications: In Vitro Tumor Cell Biology and in Vivo Chick Embryo Chorioallantoic Membrane Studies

ACS Omega ◽  
2019 ◽  
Vol 4 (17) ◽  
pp. 17244-17250 ◽  
Author(s):  
Bruno F. O. Nascimento ◽  
Mafalda Laranjo ◽  
Nelson A. M. Pereira ◽  
João Dias-Ferreira ◽  
Marta Piñeiro ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Chick Embryo ◽  
Tumor Cell ◽  
Cell Biology ◽  
Chorioallantoic Membrane ◽  
Tumor Cell Biology ◽  
Chick Embryo Chorioallantoic Membrane

scholarly journals The Potential Use of Electrochemotherapy in the Treatment of Uveal Melanoma: In Vitro Results in 3D Tumor Cultures and In Vivo Results in a Chick Embryo Model

Cancers ◽  
2019 ◽  
Vol 11 (9) ◽  
pp. 1344 ◽  
Author(s):  
Miltiadis Fiorentzis ◽  
Arne Viestenz ◽  
Udo Siebolts ◽  
Berthold Seitz ◽  
Sarah E. Coupland ◽  
...  
Keyword(s):  
Chick Embryo ◽  
Uveal Melanoma ◽  
Chorioallantoic Membrane ◽  
In Vivo Model ◽  
Metastatic Lesions ◽  
Diphenyltetrazolium Bromide ◽  
Chick Embryo Chorioallantoic Membrane ◽  
Tumors Of The Liver

Uveal melanoma (UM) is the most common primary intraocular tumor that arises from neoplastic melanocytes in the choroid, iris, and ciliary body. Electrochemotherapy (ECT) has been successfully established for the treatment of skin and soft tissue metastatic lesions, deep-seated tumors of the liver, bone metastases, and unresectable pancreas lesions. The aim of this study was to evaluate the effect of ECT in vitro in 3D spheroid culture systems in primary and metastatic UM cell lines. We also investigated the chick embryo chorioallantoic membrane (CAM) as an in vivo model system for the growth and treatment of UM tumors using ECT. The cytotoxic effect of ECT in 3D spheroids was analyzed seven days following treatment by assessment of the size and MTT [(3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) tetrazolium reduction] assay. The cytotoxicity of ECT after intratumoral or intraarterial administration was evaluated histologically. In vitro and in vivo ECT caused a significant reduction in tumor size and viability compared to electroporation or chemotherapy in both sections of our study. The current results underline the effectiveness of ECT in the treatment of UM and prepare the way for further investigation of its potential application in UM.

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