scholarly journals Fast Gradient Elution Reversed-Phase HPLC with Diode-Array Detection as a High Throughput Screening Method for Drugs of Abuse

2005 ◽  
Author(s):  
Peter W. Carr ◽  
K.M. Fuller ◽  
D.R. Stoll ◽  
L.D. Steinkraus ◽  
M.S. Pasha ◽  
...  
Keyword(s):  
High Throughput Screening ◽  
Drugs Of Abuse ◽  
Screening Method ◽  
Gradient Elution ◽  
Reversed Phase ◽  
Diode Array ◽  
Diode Array Detection ◽  
Reversed Phase Hplc ◽  
Array Detection ◽  
Fast Gradient

Amisulpride poisoning: a report on two cases

1995 ◽  
Vol 14 (3) ◽  
pp. 294-298 ◽  
Author(s):  
A. Tracqui ◽  
C. Mutter-Schmidt ◽  
P. Kintz ◽  
C. Berton ◽  
P. Mangin
Keyword(s):  
Qt Interval ◽  
Reversed Phase ◽  
Diode Array ◽  
Diode Array Detection ◽  
Reversed Phase Hplc ◽  
Drug Determination ◽  
Substituted Benzamides ◽  
Array Detection ◽  
Human Poisoning ◽  
Extrapyramidal Features

The first two observations of human poisoning involving the recently developed neuroleptic amisulpride are described. In both cases drug determination was per formed using reversed-phase HPLC coupled with diode- array detection. Case 1 was a nonfatal overdosage in which the ingestion of 3.0 g amisulpride induced an attack of seizures, then light coma with agitation, hyperthermia, mydriasis, minimal extrapyramidal features, tachycardia and slight prolongation of the QT interval; the blood con centration of amisulpride was 9.63 μg ml-1. Case 2 was a fatality attributed to amisulpride in which the measured blood concentration was 41.70 μg ml-1. Our results are discussed in the light of data previously reported on the toxicity of substituted benzamides.

Sign in / Sign up

Export Citation Format

Share Document