scholarly journals Final technical report for Interagency Agreement No. DE-AI02-98ER62683: Development of a functional genomics approach to use radiation-induced changes in gene expression to monitor for low dose and low dose-rate exposures

2001 ◽  
Author(s):  
Jr. Albert J. Fornace
Keyword(s):  
Gene Expression ◽  
Functional Genomics ◽  
Dose Rate ◽  
Low Dose ◽  
Low Dose Rate ◽  
Technical Report ◽  
Radiation Induced ◽  
Induced Changes

scholarly journals Gene expression profiling in undifferentiated thyroid carcinoma induced by high-dose radiation

2016 ◽  
Vol 57 (3) ◽  
pp. 238-249 ◽  
Author(s):  
Hyun Soon Bang ◽  
Moo Hyun Choi ◽  
Cha Soon Kim ◽  
Seung Jin Choi
Keyword(s):  
Gene Expression ◽  
Gene Expression Profiling ◽  
Dose Rate ◽  
Expression Profiling ◽  
Low Dose ◽  
High Dose Rate ◽  
Human Thyroid ◽  
High Dose ◽  
Low Dose Rate ◽  
Radiation Induced

Abstract Published gene expression studies for radiation-induced thyroid carcinogenesis have used various methodologies. In this study, we identified differential gene expression in a human thyroid epithelial cell line after exposure to high-dose γ-radiation. HTori-3 cells were exposed to 5 or 10 Gy of ionizing radiation using two dose rates (high-dose rate: 4.68 Gy/min, and low-dose rate: 40 mGy/h) and then implanted into the backs of BALB/c nude mice after 4 (10 Gy) or 5 weeks (5 Gy). Decreases in cell viability, increases in giant cell frequency, anchorage-independent growth in vitro , and tumorigenicity in vivo were observed. Particularly, the cells irradiated with 5 Gy at the high-dose rate or 10 Gy at the low-dose rate demonstrated more prominent tumorigenicity. Gene expression profiling was analyzed via microarray. Numerous genes that were significantly altered by a fold-change of >50% following irradiation were identified in each group. Gene expression analysis identified six commonly misregulated genes, including CRYAB, IL-18, ZNF845, CYP24A1, OR4N4 and VN1R4, at all doses. These genes involve apoptosis, the immune response, regulation of transcription, and receptor signaling pathways. Overall, the altered genes in high-dose rate (HDR) 5 Gy and low-dose rate (LDR) 10 Gy were more than those of LDR 5 Gy and HDR 10 Gy. Thus, we investigated genes associated with aggressive tumor development using the two dosage treatments. In this study, the identified gene expression profiles reflect the molecular response following high doses of external radiation exposure and may provide helpful information about radiation-induced thyroid tumors in the high-dose range.

The Progress of ICRP New Recommendations

2010 ◽  
Author(s):  
Aiguo Shang ◽  
Changjie Lu ◽  
Jin Qin
Keyword(s):  
Comparative Analysis ◽  
Dose Rate ◽  
Low Dose ◽  
System Analysis ◽  
Weighting Factor ◽  
Radiological Protection ◽  
Stochastic Effects ◽  
Risk Coefficient ◽  
Low Dose Rate ◽  
Radiation Induced

In order to probe into the usage of the Recommendations of the ICRP, through comparative analysis of low-dose-rate radiation-induced stochastic effects of a nominal risk coefficient, radiation weighting factor, tissue weighting factor as well as the the implementation of changes on the radiological protection system, analysis of the international on Radiological Protection fundamental recommendations of the Committee on the latest changes in radiological protection and development, and that these changes can not affect the existing radiation protection of China’s basic policy and standards.

Low Doses of Very Low-Dose-Rate Low-LET Radiation Suppress Radiation-Induced Neoplastic TransformationIn Vitroand Induce an Adaptive Response

2008 ◽  
Vol 169 (3) ◽  
pp. 311-318 ◽  
Author(s):  
E. Elmore ◽  
X-Y. Lao ◽  
R. Kapadia ◽  
E. Giedzinski ◽  
C. Limoli ◽  
...  
Keyword(s):  
Dose Rate ◽  
Adaptive Response ◽  
Low Dose ◽  
Low Doses ◽  
Low Dose Rate ◽  
Radiation Induced

Radiation-Induced Segregation in 316 and 304 Stainless Steels Irradiated at Low Dose Rate

2000 ◽  
Vol 650 ◽  
Author(s):  
T. R. Allen ◽  
J. I. Cole ◽  
J. Ohta ◽  
K. Dohi ◽  
H. Kusanagi ◽  
...  
Keyword(s):  
Stainless Steel ◽  
Grain Boundary ◽  
Dose Rate ◽  
Stainless Steels ◽  
Low Dose ◽  
Bulk Composition ◽  
304 Stainless Steel ◽  
316 Stainless Steel ◽  
Low Dose Rate ◽  
Radiation Induced

ABSTRACTAs part of the shutdown of the EBR-II reactor, structural materials were retrieved to analyze the effects of long-term irradiation on mechanical properties and microstructure. In this work, the effect of low dose rate irradiation (10−7 to 10−8 dpa/s) on grain boundary composition in 316 and 304 stainless steels was analyzed. Samples were taken from surveillance specimens and subassemblies irradiated in the reflector region of EBR-II at temperatures from 371-390°C to maximum doses of 30 dpa. The effects of dose, dose rate, and bulk composition on radiation- induced segregation are analyzed. In 316 stainless steel, changes in grain boundary chromium and nickel concentrations occur faster than changes in iron and molybdenum concentrations. In 304 stainless steel, decreasing the dose rate increases the amount of grain boundary segregation. For a dose of 20 dpa, chromium depletion and nickel enrichment are greater in 304 stainless steel than in 316 stainless steel, the difference most likely due to dose rate. In both 304 and 316 stainless steels, the presence of a grain boundary precipitate significantly changes the composition of the adjacent grain boundary.

Low-dose, low-dose-rate proton radiation modulates CD4+T cell gene expression

2009 ◽  
Vol 85 (3) ◽  
pp. 250-261 ◽  
Author(s):  
Daila S. Gridley ◽  
Michael J. Pecaut ◽  
Asma Rizvi ◽  
George B. Coutrakon ◽  
Xian Luo-Owen ◽  
...  
Keyword(s):  
Gene Expression ◽  
T Cell ◽  
Dose Rate ◽  
Low Dose ◽  
Cd4 T Cell ◽  
Proton Radiation ◽  
Low Dose Rate ◽  
Cell Gene Expression ◽  
Cell Gene
Sign in / Sign up

Export Citation Format

Share Document