scholarly journals Development of small-diameter lead-glass-tube matrices for gamma-ray conversion in positron emission tomography

1985 ◽  
Author(s):  
G.M. Schwartz
2007 ◽  
Vol 1038 ◽  
Author(s):  
Edgar Van Loef ◽  
Yimin Wang ◽  
Jarek Glodo ◽  
Charles Brecher ◽  
Alex Lempicki ◽  
...  

AbstractA review is presented of recent ceramic scintillator R&D. Attention is focussed on Ce doped gamma-ray scintillators for medical imaging applications. Ceramic scintillators discussed in detail include SrHfO3:Ce and Lu2Hf2O7:Ce. These materials combine a high density and high atomic number with fast emission and a good light yield and may find practical application in medical imaging modalities such as Positron Emission Tomography and Computed Tomography.


2008 ◽  
Vol 55 (1) ◽  
pp. 469-480 ◽  
Author(s):  
Virginia Ch. Spanoudaki ◽  
David P. McElroy ◽  
Irene Torres-Espallardo ◽  
Sibylle I. Ziegler

Small ◽  
2016 ◽  
Vol 12 (21) ◽  
pp. 2872-2876 ◽  
Author(s):  
Yonghua Zhan ◽  
Fanrong Ai ◽  
Feng Chen ◽  
Hector F. Valdovinos ◽  
Hakan Orbay ◽  
...  

Sensors ◽  
2021 ◽  
Vol 21 (16) ◽  
pp. 5566
Author(s):  
Kuntai Park ◽  
Jiwoong Jung ◽  
Yong Choi ◽  
Hyuntae Leem ◽  
Yeonkyeong Kim

The purpose of this study was to investigate the feasibility of a time-of-flight (TOF) brain positron emission tomography (PET) providing high-quality images. It consisted of 30 detector blocks arranged in a ring with a diameter of 257 mm and an axial field of view of 52.2 mm. Each detector block was composed of two detector modules and two application-specific integrated circuit (ASIC) chips. The detector module was composed of an 8 × 8 array of 3 × 3 mm2 multi-pixel photon counters and an 8 × 8 array of 3.11 × 3.11 × 15 mm3 lutetium yttrium oxyorthosilicate scintillators. The 64-channel individual readout ASIC was used to acquire the position, energy, and time information of a detected gamma ray. A coincidence timing resolution of 187 ps full width at half maximum (FWHM) was achieved using a pair of channels of two detector modules. The energy resolution and spatial resolution were 6.6 ± 0.6% FWHM (without energy nonlinearity correction) and 2.5 mm FWHM, respectively. The results of this study demonstrate that the developed TOF brain PET could provide excellent performance, allowing for a reduction in radiation dose or scanning time for brain imaging due to improved sensitivity and signal-to-noise ratio.


Nanomaterials ◽  
2020 ◽  
Vol 10 (6) ◽  
pp. 1090
Author(s):  
Andrey G. Kazakov ◽  
Bogdan L. Garashchenko ◽  
Milana K. Ivanova ◽  
Sergey E. Vinokurov ◽  
Boris F. Myasoedov

In present work, carbon nanomaterials (CNMs) are investigated as potential carriers of 68Ga, which is widely used in positron emission tomography (PET) in nuclear medicine. Sorption behavior of 68Ga was studied onto CNMs of various structures and chemical compositions: nanodiamonds (ND), reduced graphite oxide (rGiO) and multi-walled carbon nanotubes (MWCNT), as well as their oxidized (ND–COOH) or reduced (rGiO–H, MWCNT–H) forms. The physicochemical properties of the nanoparticles were determined by high resolution transmission electron microscopy, x-ray photoelectron spectroscopy, dynamic light scattering and potentiometric titration. The content of 68Ga in the solutions during the study of sorption was determined by gamma-ray spectrometry. The highest degree of 68Ga sorption was observed on ND and ND–COOH samples, and the optimal sorption conditions were determined: an aqueous solution with a pH of 5–7, m/V ratio of 50 μg/mL and a room temperature (25 °C). The 68Ga@ND and 68Ga@ND–COOH conjugates were found to be stable in a model blood solution—phosphate-buffered saline with a pH of 7.3, containing 40 g/L of bovine serum albumin: 68Ga desorption from these samples in 90 minutes was no more than 20% at 25 °C and up to 30% at 37 °C. Such a quantity of desorbed 68Ga does not harm the body and does not interfere with the PET imaging process. Thus, ND and ND–COOH are promising CNMs for using as carriers of 68Ga for PET diagnostics.


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