The main objective of this study is to estimate the effects of some considerable fuel design parameters on the fluid elastic instability behavior of the fuel rod. For the estimation, 6 fuel design parameters which seem to have direct relation with fluid elastic instability behavior of the fuel rod have been selected and examined using the PLUS7 fuel rod for OPR1000 PWR plants in Korea. Those are fuel rod creep-down, spacer grid stiffness, spacer grid spring relaxation, inactive spacer grid spring, intermediate flow mixing grid effect and fuel rod damping. As a result, the fluid elastic instability factors are insensitive with spacer grid stiffness, relaxation and intermediate flow mixing grid effect, but the other parameters need to be controlled and evaluated appropriately to maintain stability with proper margins.