scholarly journals A Hierarchical Gibbs Sampler for Spatially Varying Multi-Regularization Image Reconstructions

2021 ◽  
Author(s):  
Marylesa Howard ◽  
Jesses Adams
Keyword(s):  
Gibbs Sampler ◽  
Image Reconstructions ◽  
Spatially Varying

scholarly journals Short-Time Recurrences of Plasmodium vivax Malaria as a Public Health Proxy for Chloroquine-Resistance Surveillance: A Spatio-Temporal Study in the Brazilian Amazon

2021 ◽  
Vol 18 (10) ◽  
pp. 5061
Author(s):  
Antonio A. S. Balieiro ◽  
Andre M. Siqueira ◽  
Gisely C. Melo ◽  
Wuelton M. Monteiro ◽  
Vanderson S. Sampaio ◽  
...  
Keyword(s):  
Plasmodium Vivax ◽  
Multilevel Models ◽  
Malaria Incidence ◽  
Chloroquine Resistance ◽  
Spatial Clusters ◽  
Temporal Study ◽  
Plasmodium Vivax Malaria ◽  
Spatio Temporal ◽  
Spatially Varying ◽  
Short Time

In Brazil, malaria caused by Plasmodium vivax presents control challenges due to several reasons, among them the increasing possibility of failure of P. vivax treatment due to chloroquine-resistance (CQR). Despite limited reports of CQR, more extensive studies on the actual magnitude of resistance are still needed. Short-time recurrences of malaria cases were analyzed in different transmission scenarios over three years (2005, 2010, and 2015), selected according to malaria incidence. Multilevel models (binomial) were used to evaluate association of short-time recurrences with variables such as age. The zero-inflated Poisson scan model (scanZIP) was used to detect spatial clusters of recurrences up to 28 days. Recurrences compose less than 5% of overall infection, being more frequent in the age group under four years. Recurrences slightly increased incidence. No fixed clusters were detected throughout the period, although there are clustering sites, spatially varying over the years. This is the most extensive analysis of short-time recurrences worldwide which addresses the occurrence of P. vivax CQR. As an important step forward in malaria elimination, policymakers should focus their efforts on young children, with an eventual shift in the first line of malaria treatment to P. vivax.

scholarly journals Azimuthal Anchoring Strength in Photopatterned Alignment of a Nematic

Crystals ◽  
2021 ◽  
Vol 11 (6) ◽  
pp. 675
Author(s):  
H. Nilanthi Padmini ◽  
Mojtaba Rajabi ◽  
Sergij V. Shiyanovskii ◽  
Oleg D. Lavrentovich
Keyword(s):  
Liquid Crystal ◽  
Point Defects ◽  
Elastic Energy ◽  
Separation Distance ◽  
Thin Layers ◽  
Uv Exposure ◽  
Surface Anchoring ◽  
Anchoring Strength ◽  
Spatially Varying

Spatially-varying director fields have become an important part of research and development in liquid crystals. Characterization of the anchoring strength associated with a spatially-varying director is difficult, since the methods developed for a uniform alignment are seldom applicable. Here we characterize the strength of azimuthal surface anchoring produced by the photoalignment technique based on plasmonic metamsaks. The measurements used photopatterned arrays of topological point defects of strength +1 and −1 in thin layers of a nematic liquid crystal. The integer-strength defects split into pairs of half-integer defects with lower elastic energy. The separation distance between the split pair is limited by the azimuthal surface anchoring, which allows one to determine the strength of the latter. The strength of the azimuthal anchoring is proportional to the UV exposure time during the photoalignment of the azobenzene layer.

scholarly journals INFORM: INFrared-based ORganizational Measurements of tumor and its microenvironment to predict patient survival

2021 ◽  
Vol 7 (6) ◽  
pp. eabb8292
Author(s):  
Saumya Tiwari ◽  
Andre Kajdacsy-Balla ◽  
Joshua Whiteley ◽  
Georgina Cheng ◽  
Stephen M. Hewitt ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Cancer Progression ◽  
Spatial Organization ◽  
Infrared Imaging ◽  
Patient Survival ◽  
High Definition ◽  
Risk Of Death ◽  
Measurement Framework ◽  
Spatially Varying ◽  
Physical And Chemical

The structure and organization of a tumor and its microenvironment are often associated with cancer outcomes due to spatially varying molecular composition and signaling. A persistent challenge is to use this physical and chemical spatial organization to understand cancer progression. Here, we present a high-definition infrared imaging–based organizational measurement framework (INFORM) that leverages intrinsic chemical contrast of tissue to label unique components of the tumor and its microenvironment. Using objective and automated computational methods, further, we determine organization characteristics important for prediction. We show that the tumor spatial organization assessed with this framework is predictive of overall survival in colon cancer that adds to capability from clinical variables such as stage and grade, approximately doubling the risk of death in high-risk individuals. Our results open an all-digital avenue for measuring and studying the association between tumor spatial organization and disease progression.

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