scholarly journals Toxicology Studies on Lewisite and Sulfur Mustard Agents: Subchronic Toxicity Study of Lewisite in Rats Final Report

1989 ◽  
Author(s):  
L. B. Sasser ◽  
J. A. Cushing ◽  
D. R. Kalkwarf ◽  
P. W. Mellick ◽  
R. L. Buschbom
Keyword(s):  
Sulfur Mustard ◽  
Toxicity Study ◽  
Final Report ◽  
Subchronic Toxicity

scholarly journals Toxicology Studies on Lewisite and Sulfur Mustard Agents: Subchronic Toxicity of Sulfur Mustard (HD) In Rats Final Report

1989 ◽  
Author(s):  
L. B. Sasser ◽  
R. A. Miller ◽  
Kalkwarf, D, R. ◽  
R. L. Buschbom ◽  
J. A. Cushing
Keyword(s):  
Sulfur Mustard ◽  
Final Report ◽  
Subchronic Toxicity

scholarly journals Acute and subchronic toxicity study of nonpolar extract of licorice roots in mice

2020 ◽  
Vol 8 (5) ◽  
pp. 2242-2250
Author(s):  
Hyun‐Yong Kim ◽  
Guanglei Zuo ◽  
Soo Kyeong Lee ◽  
Soon Sung Lim
Keyword(s):  
Toxicity Study ◽  
Subchronic Toxicity

Subchronic toxicity study of the total flavonoids from Rosa laevigata Michx fruit in rats

2012 ◽  
Vol 62 (2) ◽  
pp. 221-230 ◽  
Author(s):  
Shuai Zhang ◽  
Lingli Zheng ◽  
Lina Xu ◽  
Huijun Sun ◽  
Hua Li ◽  
...  
Keyword(s):  
Toxicity Study ◽  
Total Flavonoids ◽  
Subchronic Toxicity ◽  
Rosa Laevigata

Final Report on the Safety Assessment of Polyacrylamide

1991 ◽  
Vol 10 (1) ◽  
pp. 193-203 ◽  
Keyword(s):  
Body Weight ◽  
Adverse Effects ◽  
Safety Assessment ◽  
Maximum Dose ◽  
Toxicity Study ◽  
Final Report ◽  
Oral Toxicity ◽  
Monomer Content ◽  
Acrylamide Monomers ◽  
Reproductive Study

Polyacrylamide is a polymer of controllable molecular weight formed from the polymerization of acrylamide monomers. Average concentrations of the monomer were reported as less than 0.01% by several manufacturers. Polyacrylamide is used as a foam builder and stabilizer in shampoo products and as a vehicle in sunscreen preparations. An acute oral toxicity study of Polyacrylamide in rats reported that a single maximum oral dose of 4.0 g/kg body weight was tolerated. In a subchronic oral toxicity study in both rats and dogs, animals were given a maximum dose of 464 mg/kg body weight, with no signs of toxicity in any animals. Two separate studies in rats reported no absorption when the compound was administered by gavage. In a 2-year chronic oral toxicity study, rats fed between 500 and 10,000 ppm in their diet had no significant adverse effects. Similar results were obtained in dogs. A 2-year feeding study in rats fed up to 5.0% Polyacrylamide reported no significant adverse effects. Cutaneous tolerance tests performed to evaluate the irritation of Polyacrylamide indicated that the compound was relatively well tolerated. Undiluted Polyacrylamide applied to the conjunctival sac of the rabbit caused a very slight response. No compound-related lesions were noted in a three-generation reproductive study in which rats were fed either 500 or 2000 ppm Polyacrylamide. On the basis of data presented in this report, it is concluded that Polyacrylamide, with less than 0.01% acrylamide monomer content, is safe as a cosmetic ingredient as currently used.

Safety assessment of Apoaequorin, a protein preparation: Subchronic toxicity study in rats

2013 ◽  
Vol 57 ◽  
pp. 1-10 ◽  
Author(s):  
Daniel L. Moran ◽  
Palma Ann Marone ◽  
Mark R. Bauter ◽  
Madhu G. Soni
Keyword(s):  
Safety Assessment ◽  
Toxicity Study ◽  
Subchronic Toxicity ◽  
Protein Preparation

scholarly journals Safety assessment of Euglena gracilis ATCC 12894 whole cell biomass

2019 ◽  
Vol 3 ◽  
pp. 239784731989522
Author(s):  
Jennifer Symonds ◽  
Chonggang Zhang ◽  
Adam Noble ◽  
Claire Kruger
Keyword(s):  
Euglena Gracilis ◽  
Safety Assessment ◽  
Wistar Rats ◽  
Micronucleus Assay ◽  
Toxicity Study ◽  
Subchronic Toxicity ◽  
Whole Cell ◽  
Reverse Mutation ◽  
Test Article ◽  
Cell Biomass

A safety assessment of the dried whole cell biomass of Euglena gracilis ATCC 12894 was performed by the bacterial reverse mutation (Ames) assay, an in vitro micronucleus assay, and a 90-day repeat oral toxicity study in Wistar rats. E. gracilis ATCC 12894 whole cell biomass has no added excipients and contains 33.8% protein, 28.8% β-glucans, 19.8% fat, 7.1% ash, and 2.8% moisture. The bacterial reverse mutation assay found no evidence of mutagenicity after exposure to E. gracilis ATCC 12894 whole cell biomass, with or without metabolic activity, at levels up to 1581 µg/plate, the limit dose for the assay. Similarly, no evidence of genotoxicity was observed in the micronucleus assay, with or without metabolic activation, up to 320 µg/mL, the limit dose for the assay. The subchronic toxicity study was performed with the following test article dose groups: 0 (control), 1250, 2500, and 5000 mg/kg/day, administered to male and female Wistar rats via oral gavage for 90 days. No test article-related mortalities or adverse events were reported during the study. Histopathological examination revealed some vacuolation in the livers of males in the 5000 mg/kg/day group. This finding was considered adaptive, due to the approximately 20% fat content of whole cell biomass, and was therefore test article-related, but not adverse. No such findings were reported in female rats in the study. The results of the subchronic toxicity study describe a no observed adverse effect level of at least 5000 mg/kg/day.

Final Report on the Safety Assessment of Cetethyl Morpholinium Ethosulfate

2001 ◽  
Vol 20 (3_suppl) ◽  
pp. 99-102 ◽  
Keyword(s):  
Safety Assessment ◽  
Developmental Toxicity ◽  
Quaternary Salt ◽  
Skin Penetration ◽  
Toxicity Study ◽  
Final Report ◽  
Inhalation Toxicity ◽  
Absorption Data ◽  
Dermal Irritation ◽  
Safety Test

Cetethyl Morpholinium Ethosulfate is a quaternary salt used as an antistatic agent and as a surfactant in several hair care products. The concentration at which this ingredient is used is unknown, although data reported in 1984 indicated a maximum concentration of 1%. In an inhalation toxicity study, the approximate lethal concentration of Cetethyl Morpholinium Ethosulfate was 0.403 mg/mm3. This ingredient was shown to be a severe ocular irritant in an animal study. No other safety test data on this ingredient were available. These data were clearly insufficient to support the safety of Cetethyl Morpholinium Ethosulfate in cosmetics. Data available on Morpholine were summarized, but these data themselves were insufficient to support safety. The data needed in order to complete the safety assessment of Cetethyl Morpholinium Ethosulfate include: methods of manufacture and impurities, especially nitrosamines; current concentration of use; skin penetration; if there is significant skin penetration, then both a 28-day dermal toxicity study to assess general skin and systemic toxicity and a reproductive and developmental toxicity study are needed; two genotoxicity studies, at least one in a mammalian system, if positive, then a 2-year dermal carcinogenisis study using National Toxicology Program (NTP) methods may be needed; ultraviolet (UV) absorption data, if significantly absorbed, then photosensitization data are needed; dermal irritation and sensitization; and ocular toxicity, if available.

Subchronic toxicity study in rats fed gum karaya

1982 ◽  
Vol 20 (5) ◽  
pp. 513-517 ◽  
Author(s):  
P.J.Y. Taupin ◽  
D.M.W. Anderson
Keyword(s):  
Toxicity Study ◽  
Subchronic Toxicity ◽  
Gum Karaya

13‐Week subchronic toxicity study with morpholine oleic acid salt administered to B6C3F1 mice

1987 ◽  
Vol 22 (2) ◽  
pp. 187-194 ◽  
Author(s):  
Masa‐Aki Shibata ◽  
Yasushi Kurata ◽  
Seiko Tamano ◽  
Tadashi Ogiso ◽  
Shoji Fukushima ◽  
...  
Keyword(s):  
Oleic Acid ◽  
Toxicity Study ◽  
Acid Salt ◽  
Subchronic Toxicity ◽  
B6c3f1 Mice

scholarly journals Subchronic toxicity study of ethanolic extract of Uvaria chamae root in rats

2018 ◽  
Vol 17 (5) ◽  
pp. 831 ◽  
Author(s):  
Fidelis E. Olumese ◽  
Iyere O. Onoagbe ◽  
Gerald I. Eze ◽  
Felix O. Omoruyi
Keyword(s):  
Ethanolic Extract ◽  
Toxicity Study ◽  
Subchronic Toxicity
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