No evidence of direct cardiac action of leucine-enkephalin in canine heart-lung preparation.

1984 ◽  
Vol 34 (2) ◽  
pp. 351-355 ◽  
Author(s):  
Shozo KOYAMA ◽  
Nobuyuki TERADA ◽  
Yumiko SHIOJIMA ◽  
Toru TAKEUCHI
Keyword(s):  
Canine Heart ◽  
Leucine Enkephalin ◽  
Cardiac Action ◽  
Lung Preparation

scholarly journals Factors causing a spontaneous increase in coronary blood flow in the canine heart-lung preparation

1984 ◽  
Vol 36 ◽  
pp. 264
Author(s):  
Motoshi Kainuma ◽  
Itaru Ichimura ◽  
Naohisa Ishikawa ◽  
Tatsuro Shigei.
Keyword(s):  
Blood Flow ◽  
Coronary Blood Flow ◽  
Canine Heart ◽  
Lung Preparation

scholarly journals Effects of a new adrenergic β-blocking agent, Kö 1400 on the canine heart-lung preparation supported by a donor dog and the perfused hindlimb preparation of the dog

1977 ◽  
Vol 73 (4) ◽  
pp. 411-421 ◽  
Author(s):  
Yoshito NAKAGAWA ◽  
Keisuke TAKEDA ◽  
Yumi KATANO ◽  
Tokumasa TSUKADA ◽  
Issei MATSUBARA ◽  
...  
Keyword(s):  
Blocking Agent ◽  
Canine Heart ◽  
Lung Preparation

scholarly journals Action of Dinitrophenol and Lanatoside C on the Canine Heart-Lung Preparation

1955 ◽  
Vol 3 (1) ◽  
pp. 32-38 ◽  
Author(s):  
E. ROTHLIN ◽  
M. TAESCHLER ◽  
A. CERLETTI
Keyword(s):  
Canine Heart ◽  
Lung Preparation ◽  
Lanatoside C

An improved heart-lung preparation ventilated by negative pressure

1961 ◽  
Vol 16 (1) ◽  
pp. 186-190
Author(s):  
William L. Sheehan ◽  
William B. Kinzie ◽  
Kenneth L. Westbrook ◽  
William A. Spencer ◽  
Hebbel E. Hoff
Keyword(s):  
Survival Time ◽  
Negative Pressure ◽  
Canine Heart ◽  
Improved Performance ◽  
Lung Preparation

Five isolated canine heart-lung preparations were successfully ventilated with intermittent negative pressure in a specially constructed chamber. Improved cardiopulmonary dynamics resulted in increased survival time and improved performance of all preparations. Results obtained with these preparations exceed most of the others reported in the literature. Submitted on May 9, 1960

Mechanism of reduced LV afterload by systolic and diastolic positive pleural pressure

1988 ◽  
Vol 65 (3) ◽  
pp. 1244-1250 ◽  
Author(s):  
H. E. Fessler ◽  
R. G. Brower ◽  
R. A. Wise ◽  
S. Permutt
Keyword(s):  
Thoracic Aorta ◽  
Left Atrial ◽  
Statistical Difference ◽  
Venous Return ◽  
Left Ventricular ◽  
Pleural Pressure ◽  
Canine Heart ◽  
Central Blood Volume ◽  
Great Vessels ◽  
Lung Preparation

To investigate the mechanism by which increased pleural pressure (Ppl) assists left ventricular (LV) ejection, we compared the effects of phasic systolic or diastolic increases in Ppl (40-60 mmHg) with use of an isolated canine heart-lung preparation with constant venous return. Positive Ppl during systole (S) caused left atrial transmural pressure (Platm = Pla - Ppl) to decrease by 1.25 +/- 0.46 (SE) mmHg (P less than 0.025). Central blood volume (CBV), the volume of blood in the heart, lungs, and thoracic great vessels, decreased by 29 +/- 4.0 (SE) ml (P less than 0.001). When Ppl was raised for an equal duration during diastole (D), the decrease in Platm was not significant, but there was a significant decrease in CBV (10.5 +/- 4.1 ml, P less than 0.05). With constant venous return, these changes suggested that phasic elevations in Ppl in either S or D assisted LV ejection by decreasing LV afterload. To test the hypothesis that positive Ppl during D reduced afterload by emptying the thoracic aorta, we compared the effects of diastolic positive Ppl with a rigid aorta vs. a compliant aorta. Although there was no statistical difference in the effects of diastolic positive Ppl on Platm, the decrease in CBV was significantly greater when the aorta was compliant than when it was rigid (23 +/- 2.2 vs. 17 +/- 2.7 ml, P less than 0.05).(ABSTRACT TRUNCATED AT 250 WORDS)

scholarly journals Cardiotonic and Coronary Vasodilatatory Effects of Amrinone in the Canine Heart-Lung Preparation with a Support Dog as Compared with Those of Dobutamine

1986 ◽  
Vol 40 (3) ◽  
pp. 381-387 ◽  
Author(s):  
Keisuke TAKEDA ◽  
Kazuki MATSUI ◽  
Mikio NAKAZAWA ◽  
Hajime NAKAHARA ◽  
Hirohisa IMAI ◽  
...  
Keyword(s):  
Canine Heart ◽  
Lung Preparation

New Molecular Scaffolds for Fluorescent Voltage Indicators

2018 ◽  
Author(s):  
Steven Boggess ◽  
Shivaani Gandhi ◽  
Brian Siemons ◽  
Nathaniel Huebsch ◽  
Kevin Healy ◽  
...  
Keyword(s):  
Membrane Potential ◽  
Action Potentials ◽  
Induced Pluripotent Stem Cell ◽  
Molecular Wire ◽  
Voltage Sensing ◽  
Design Synthesis ◽  
Cardiac Action ◽  
Action Potential Waveform ◽  
Induced Pluripotent ◽  
Voltage Sensing Domain

<div> <p>The ability to non-invasively monitor membrane potential dynamics in excitable cells like neurons and cardiomyocytes promises to revolutionize our understanding of the physiology and pathology of the brain and heart. Here, we report the design, synthesis, and application of a new class of fluorescent voltage indicator that makes use of a fluorene-based molecular wire as a voltage sensing domain to provide fast and sensitive measurements of membrane potential in both mammalian neurons and human-derived cardiomyocytes. We show that the best of the new probes, fluorene VoltageFluor 2 (fVF 2) readily reports on action potentials in mammalian neurons, detects perturbations to cardiac action potential waveform in human induced pluripotent stem cell (hiPSC)-derived cardiomyocytes, shows a substantial decrease in phototoxicity compared to existing molecular wire-based indicators, and can monitor cardiac action potentials for extended periods of time. Together, our results demonstrate the generalizability of a molecular wire approach to voltage sensing and highlights the utility of fVF 2 for interrogating membrane potential dynamics.</p> </div>

How to Fluorescently Label the Potassium Channel: A Case in hERG

2020 ◽  
Vol 27 (18) ◽  
pp. 3046-3054
Author(s):  
Xiaomeng Zhang ◽  
Beilei Wang ◽  
Zhenzhen Liu ◽  
Yubin Zhou ◽  
Lupei Du
Keyword(s):  
Potassium Channel ◽  
Herg Channel ◽  
Pore Channel ◽  
Design Rationale ◽  
Related Gene ◽  
Open Conformation ◽  
Cardiac Action ◽  
Qt Syndrome ◽  
Herg Channels ◽  
Action Potential Repolarization

hERG (Human ether-a-go-go-related gene) potassium channel, which plays an essential role in cardiac action potential repolarization, is responsible for inherited and druginduced long QT syndrome. Recently, the Cryo-EM structure capturing the open conformation of hERG channel was determined, thus pushing the study on hERG channel at 3.8 Å resolution. This report focuses primarily on summarizing the design rationale and application of several fluorescent probes that target hERG channels, which enables dynamic and real-time monitoring of potassium pore channel affinity to further advance the understanding of the channels.

Biological Response to Bard Clamshell Septal Occluders in the Canine Heart

Circulation ◽  
1996 ◽  
Vol 93 (7) ◽  
pp. 1459-1463 ◽  
Author(s):  
Micheal A. Kuhn ◽  
Larry A. Latson ◽  
John P. Cheatham ◽  
Bruce McManus ◽  
James M. Anderson ◽  
...  
Keyword(s):  
Biological Response ◽  
Canine Heart
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