EFFECT OF COLD ADAPTATION AND HIGH-FAT DIET ON COLD RESISTANCE AND METABOLIC RESPONSES TO ACUTE COLD EXPOSURE IN RATS

1974 ◽  
Vol 24 (3) ◽  
pp. 277-292 ◽  
Author(s):  
Akihiro KUROSHIMA ◽  
Masashi KURAHASHI ◽  
Katsuhiko DOI ◽  
Tomie OHNO ◽  
Ikuko FUJITA
Keyword(s):  
Cold Exposure ◽  
High Fat Diet ◽  
Cold Adaptation ◽  
Cold Resistance ◽  
Metabolic Responses ◽  
High Fat ◽  
Acute Cold Exposure

Improved cold tolerance and its mechanism in cold-acclimated rats by high fat diet feeding

1977 ◽  
Vol 55 (4) ◽  
pp. 943-950 ◽  
Author(s):  
Akihiro Kuroshima ◽  
Katsuhiko Doi ◽  
Takehiro Yahata ◽  
Tomie Ohno
Keyword(s):  
Fatty Acid ◽  
Blood Glucose ◽  
Cold Tolerance ◽  
Cold Exposure ◽  
High Fat Diet ◽  
Metabolic Responses ◽  
Standard Diet ◽  
Nonshivering Thermogenesis ◽  
High Fat ◽  
Colonic Temperature

Cold tolerance and metabolic responses to cold were studied in cold-acclimated rats on high fat diet (CAHF). Cold tolerance at −5 °C was assessed by fall of colonic temperature of clipped rats after 18 h of fasting. Rate of fall in colonic temperature was greatest in warm-acclimated control rats (WAST), slowest in cold-acclimated rats on standard diet (CAST), and remained unchanged in CAHF during cold exposure for 240 min. Increment in blood free fatty acid (FFA) concentration 80 min after cold exposure was greatest in WAST, less in CAST, and least in CAHF. Blood glucose decreased similarly in WAST and CAST after cold exposure, while it remained unchanged in CAHF. Blood β-hydroxybutyrate also increased similarly in WAST and CAST, while it did not change in CAHF. Nonshivering thermogenesis tested by noradrenaline was greatest in CAHF, followed by CAST and WAST. Shivering induced by cold exposure was less pronounced in CAST than in WAST and did not develop in CAHF; changes in colonic temperature were inversely related to the extent of shivering during cold exposure for 90 min.These results suggest that an integrating effect of cold and high fat diet could improve cold tolerance much more than cold acclimation itself, possibly through enhanced nonshivering thermogenesis caused by metabolic modifications such as increased lipid use and gluconeogenesis.

Catecholamine turnover in S 5B/P1 and Osborne-Mendel rats: response to a high-fat diet

1984 ◽  
Vol 247 (2) ◽  
pp. R290-R295 ◽  
Author(s):  
J. S. Fisler ◽  
T. Yoshida ◽  
G. A. Bray
Keyword(s):  
Adipose Tissue ◽  
Brown Adipose Tissue ◽  
Cold Exposure ◽  
High Fat Diet ◽  
Turnover Rate ◽  
High Fat ◽  
Interscapular Brown Adipose Tissue ◽  
Catecholamine Turnover ◽  
Norepinephrine Turnover ◽  
Brown Adipose

Catecholamine turnover in response to fasting, cold exposure, and a high-fat diet has been measured in the Osborne-Mendel rat, which readily develops obesity when fed a high-fat diet, and the S 5B/P1 rat, which does not. We have tested the hypothesis that this difference in response to diet might be associated with altered rates of norepinephrine or epinephrine turnover. The endogenous norepinephrine concentration in interscapular brown adipose tissue was significantly greater in fasted S 5B/P1 rats than in fasted Osborne-Mendel rats. The fractional norepinephrine turnover rate in interscapular brown adipose tissue of fasted animals was also greater in the S 5B/P1 rat than in the Osborne-Mendel rat. Cold exposure increased the fractional norepinephrine turnover rate in interscapular brown adipose tissue for both strains of rats but increased the fractional norepinephrine turnover rate in the pancreas in only the Osborne-Mendel rats. The turnover of epinephrine and the adrenal concentration of this hormone were not different between the two strains. Normal and high-fat diets were fed to both strains; the Osborne-Mendel rats were pair fed the high-fat diet to prevent excess weight gain. Endogenous concentrations of norepinephrine in interscapular brown adipose tissue was increased by the high-fat diet; the increase was greater in S 5B/P1 rats. The high-fat diet resulted in increased norepinephrine turnover in interscapular brown adipose tissue of the S 5B/P1 rat but not the Osborne-Mendel rat.(ABSTRACT TRUNCATED AT 250 WORDS)

scholarly journals A Direct Comparison of Metabolic Responses to High-Fat Diet in C57BL/6J and C57BL/6NJ Mice

Diabetes ◽  
2016 ◽  
Vol 65 (11) ◽  
pp. 3249-3261 ◽  
Author(s):  
Kelsey H. Fisher-Wellman ◽  
Terence E. Ryan ◽  
Cody D. Smith ◽  
Laura A.A. Gilliam ◽  
Chien-Te Lin ◽  
...  
Keyword(s):  
High Fat Diet ◽  
Metabolic Responses ◽  
High Fat

scholarly journals Improvement of cold resistance and performance of broilers by acute cold exposure during late embryogenesis

2011 ◽  
Vol 90 (3) ◽  
pp. 633-641 ◽  
Author(s):  
D. Shinder ◽  
M. Ruzal ◽  
M. Giloh ◽  
S. Druyan ◽  
Y. Piestun ◽  
...  
Keyword(s):  
Cold Exposure ◽  
Cold Resistance ◽  
Acute Cold Exposure ◽  
Late Embryogenesis ◽  
And Performance

scholarly journals EFFECT OF A HIGH-FAT DIET ON METABOLIC RESPONSES TO EXERCISE

1975 ◽  
Vol 25 (5) ◽  
pp. 575-584
Author(s):  
Akihiro KUROSHIMA ◽  
Tomie OHNO ◽  
Osamu HAYAMI ◽  
Ikuko FUJITA
Keyword(s):  
High Fat Diet ◽  
Metabolic Responses ◽  
High Fat

scholarly journals Disparate Metabolic Responses in Mice Fed a High-Fat Diet Supplemented with Maize-Derived Non-Digestible Feruloylated Oligo- and Polysaccharides Are Linked to Changes in the Gut Microbiota

PLoS ONE ◽  
2016 ◽  
Vol 11 (1) ◽  
pp. e0146144 ◽  
Author(s):  
Junyi Yang ◽  
Laure B. Bindels ◽  
Rafael R. Segura Munoz ◽  
Inés Martínez ◽  
Jens Walter ◽  
...  
Keyword(s):  
Gut Microbiota ◽  
High Fat Diet ◽  
Metabolic Responses ◽  
High Fat

scholarly journals Gene Expression Analysis of Environmental Temperature and High-Fat Diet-Induced Changes in Mouse Supraclavicular Brown Adipose Tissue

Cells ◽  
2021 ◽  
Vol 10 (6) ◽  
pp. 1370
Author(s):  
Yufeng Shi ◽  
Honglei Zhai ◽  
Sharon John ◽  
Yi-Ting Shen ◽  
Yali Ran ◽  
...  
Keyword(s):  
Gene Expression ◽  
Adipose Tissue ◽  
Brown Adipose Tissue ◽  
Cold Exposure ◽  
High Fat Diet ◽  
High Fat ◽  
Nutrient Processing ◽  
Expression Of Genes ◽  
Brown Adipose ◽  
Attractive Therapeutic Target

Obesity, a dysregulation of adipose tissue, is a major health risk factor associated with many diseases. Brown adipose tissue (BAT)-mediated thermogenesis can potentially regulate energy expenditure, making it an attractive therapeutic target to combat obesity. Here, we characterize the effects of cold exposure, thermoneutrality, and high-fat diet (HFD) feeding on mouse supraclavicular BAT (scBAT) morphology and BAT-associated gene expression compared to other adipose depots, including the interscapular BAT (iBAT). scBAT was as sensitive to cold induced thermogenesis as iBAT and showed reduced thermogenic effect under thermoneutrality. While both scBAT and iBAT are sensitive to cold, the expression of genes involved in nutrient processing is different. The scBAT also showed less depot weight gain and more single-lipid adipocytes, while the expression of BAT thermogenic genes, such as Ucp1, remained similar or increased more under our HFD feeding regime at ambient and thermoneutral temperatures than iBAT. Together, these findings show that, in addition to its anatomical resemblance to human scBAT, mouse scBAT possesses thermogenic features distinct from those of other adipose depots. Lastly, this study also characterizes a previously unknown mouse deep neck BAT (dnBAT) depot that exhibits similar thermogenic characteristics as scBAT under cold exposure and thermoneutrality.

Sign in / Sign up

Export Citation Format

Share Document