scholarly journals Light synchronization of the circadian rhythm of blood pressure and plasma cortisol concentration in a case of Shy-Drager syndrome in apallic state.

1987 ◽  
Vol 76 (5) ◽  
pp. 718-724 ◽  
Author(s):  
Masanari KUNIMOTO ◽  
Yoshikazu UGAWA ◽  
Masanobu SAKAMOTO ◽  
Kiyoharu INOUE ◽  
Manabu SAKUTA
Keyword(s):  
Blood Pressure ◽  
Circadian Rhythm ◽  
Plasma Cortisol ◽  
Cortisol Concentration ◽  
Plasma Cortisol Concentration

The effect of 6-hydroxydopamine infused into the third cerebral ventricle on the plasma cortisol concentration in sheep subjected to repeated and prolonged stress stimuli

1985 ◽  
Vol 110 (4) ◽  
pp. 546-552 ◽  
Author(s):  
E. Domański ◽  
E. Stupnicka ◽  
F. Przekop ◽  
E. Wolińska-Witort
Keyword(s):  
Circadian Rhythm ◽  
Cortisol Level ◽  
Plasma Cortisol ◽  
Plasma Cortisol Level ◽  
Cortisol Concentration ◽  
Cortisol Secretion ◽  
The Third ◽  
Plasma Cortisol Concentration ◽  
6 Hydroxydopamine ◽  
Prolonged Stress

Abstract. It has previously been observed that sheep subjected to repeated and prolonged stress stimuli showed biphasic cortisol responses. On the first and second day of stimulation an elevation was observed, while on the subsequent days and on the day after the stimulation a marked suppression of plasma cortisol level and a disappearance of its circadian rhythm was noted. It was hypothesized that these changes in the secretion of the hormone were caused by the alteration of catecholaminergic systems in the CNS. To verify this suggestion chemical lesions of the catecholergic systems of the diencephalon were carried out by the infusion of 6-hydroxydopamine (6-OHDA) into the third cerebral ventricle and animals treated in this fashion were subjected to repeated and prolonged electrical mild footshocking (applied during 3 days). The pretreated animals lost the circadian rhythm in cortisol secretion on the days before as well as during and after the electrical stimulation. The animals pretreated with 6-OHDA showed a significant rise of the plasma cortisol level during stimulation. This rise, as the highest daily concentration, occurring within about 1 h after the beginning of footshocking, was significantly accelerated in time with respect to the physiological acrophase, occurring in the early morning hours at the end of prestimulatory days. On the other hand, the pretreated animals did not show the decrease of plasma cortisol levels on the day after the stimulation, observed in normal non-pretreated ones. It is suggested that the absence of the suppression of plasma cortisol concentration in the animals pretreated with 6-OHDA on the day after the stimulation may be due to the blockade of the ventral noradrenergic bundle innervating the medial basal hypothalamus, while disappearance of the circadian rhythm of cortisol secretion was due to the disturbance in the function of retinohypothalamic projection.

scholarly journals Effects of Full Inhalation of Sevoflurane and Total Intravenous Anesthesia on Hemodynamics, Serum Myocardial Enzymes, and Myocardial Markers in Elderly Patients Undergoing Hysterectomy

2021 ◽  
Vol 2021 ◽  
pp. 1-5
Author(s):  
Xing Lan ◽  
Dong Yang ◽  
Shengnan Xie ◽  
Zhenghua Zhao
Keyword(s):  
Blood Pressure ◽  
Elderly Patients ◽  
Recovery Time ◽  
Plasma Cortisol ◽  
Cortisol Concentration ◽  
Intravenous Anesthesia ◽  
Plasma Cortisol Concentration ◽  
Group A ◽  
Group B ◽  
Myocardial Enzymes

Objective. To compare the effects of sevoflurane inhalation and intravenous anesthesia on hemodynamics, serum myocardial enzymes, and myocardial markers in elderly patients undergoing hysterectomy. Methods. Group A and group B were established randomly regarding a total of 126 elderly patients who underwent an elective hysterectomy. Patients in group A were given full anesthesia with sevoflurane, and patients in group B were given anesthesia with intravenous anesthesia. The operation time, anesthesia time, and recovery time in Postanesthesia Care Unit (PACU) were compared; plasma cortisol concentration, hemodynamics, serum myocardial enzymes, and myocardial markers were detected and compared between the two groups of patients before anesthesia ( T 0 ), after anesthesia ( T 1 ), and after surgery ( T 2 ). Results. Group A observed a longer extubation time and recovery time in PACU than group B ( P < 0.05 ). Results show a lower systolic blood pressure (SBP), diastolic blood pressure (DBP), heart rate (HR), and plasma cortisol concentration of T 1 by comparison with those of T 0 ( P < 0.05 ), but no significant difference remains in terms of intergroup SBP, DBP, and HR ( P > 0.05 ), and there was no interaction effect of groups and time ( P > 0.05 ). The two groups showed no great disparity in the levels of lactate dehydrogenase (LDH), aspartate transaminase (AST), creatine kinase (CK), and CK-MB as a subtype of CK before surgery between the two groups of patients ( P > 0.05 ). After surgery, LDH, AST, CK, and CK-MB levels in both groups were witnessed a surge, in which group A obtained higher levels of LDH, AST, CK, and CK-MB (all P < 0.05 ). Conclusion. Total intravenous anesthesia will not increase the hemodynamic fluctuation of elderly patients undergoing hysterectomy and can reduce the damage to the myocardium of patients with surgical trauma, which can protect the myocardium of elderly patients to a certain extent, so it can be adopted as the optimal anesthesia protocol for surgery.

Intrauterine growth restriction delays surfactant protein maturation in the sheep fetus

2010 ◽  
Vol 298 (4) ◽  
pp. L575-L583 ◽  
Author(s):  
Sandra Orgeig ◽  
Tamara A. Crittenden ◽  
Ceilidh Marchant ◽  
I. Caroline McMillen ◽  
Janna L. Morrison
Keyword(s):  
Mrna Expression ◽  
Plasma Cortisol ◽  
Surfactant Protein ◽  
Cortisol Concentration ◽  
Plasma Catecholamine ◽  
Fetal Sheep ◽  
C Protein ◽  
Intrauterine Growth ◽  
Plasma Cortisol Concentration ◽  
The Impact

Pulmonary surfactant is synthesized by type II alveolar epithelial cells to regulate the surface tension at the air-liquid interface of the air-breathing lung. Developmental maturation of the surfactant system is controlled by many factors including oxygen, glucose, catecholamines, and cortisol. The intrauterine growth-restricted (IUGR) fetus is hypoxemic and hypoglycemic, with elevated plasma catecholamine and cortisol concentrations. The impact of IUGR on surfactant maturation is unclear. Here we investigate the expression of surfactant protein (SP) A, B, and C in lung tissue of fetal sheep at 133 and 141 days of gestation (term 150 ± 3 days) from control and carunclectomized Merino ewes. Placentally restricted (PR) fetuses had a body weight <2 SD from the mean of control fetuses and a mean gestational PaO2<17 mmHg. PR fetuses had reduced absolute, but not relative, lung weight, decreased plasma glucose concentration, and increased plasma cortisol concentration. Lung SP-A, -B, and -C protein and mRNA expression was reduced in PR compared with control fetuses at both ages. SP-B and -C but not SP-A mRNA expression and SP-A but not SP-B or -C protein expression increased with gestational age. Mean gestational PaO2was positively correlated with SP-A, -B, and -C protein and SP-B and -C mRNA expression in the younger cohort. SP-A and -B gene expression was inversely related to plasma cortisol concentration. Placental restriction, leading to chronic hypoxemia and hypercortisolemia in the carunclectomy model, results in significant inhibition of surfactant maturation. These data suggest that IUGR fetuses are at significant risk of lung complications, especially if born prematurely.

ANTIDIURETIC HORMONE AND CORTICOTROPHIN RELEASE IN MAN

1960 ◽  
Vol 21 (2) ◽  
pp. 171-176 ◽  
Author(s):  
S. SHUSTER
Keyword(s):  
Antidiuretic Hormone ◽  
Plasma Cortisol ◽  
Cortisol Concentration ◽  
Release Factor ◽  
Similar Increase ◽  
Rapid Infusion ◽  
Experimental Procedure ◽  
Plasma Cortisol Concentration ◽  
Corticotrophin Release Factor ◽  
Patients With Diabetes

SUMMARY Plasma cortisol concentrations increased after injections of nicotine. This increase was variable and was no greater than that seen after substitution of normal saline for nicotine. Plasma cortisol concentrations did not increase after nicotine in patients with hypopituitarism and after inhibition of corticotrophin release with triamcinolone. It is concluded that the increased plasma cortisol concentration after injection of nicotine was due to non-specific pituitary stimulation associated with the experimental procedure and not due to any direct effect of the nicotine. Nicotine resulted in a similar increase in plasma cortisol in four patients with diabetes insipidus. Neither rapid infusion of hypertonic mannitol nor ingestion of ethanol had a consistent effect on the plasma cortisol concentration. It is therefore concluded that the antidiuretic hormone is not the 'corticotrophin release factor' in man.

Seasonal variation in plasma cortisol concentration during pregnancy and the puerperium

1980 ◽  
Vol 8 (5) ◽  
pp. 587-588 ◽  
Author(s):  
JUDITH M. BAKER ◽  
SHEILA L. HANDLEY ◽  
GILL WALDRON ◽  
T. LESLIE DUNN
Keyword(s):  
Seasonal Variation ◽  
Plasma Cortisol ◽  
Cortisol Concentration ◽  
Plasma Cortisol Concentration

PLASMA CONCENTRATIONS OF CORTISOL IN HYPOPHYSECTOMIZED AND SODIUM CHLORIDE-ADAPTED GOLDFISH (CARASSIUS AURATUS L.)

1974 ◽  
Vol 63 (2) ◽  
pp. 377-387 ◽  
Author(s):  
JACQUELINE PORTHÉ-NIBELLE ◽  
BRAHIM LAHLOU
Keyword(s):  
Sodium Chloride ◽  
Fresh Water ◽  
Plasma Cortisol ◽  
Carassius Auratus ◽  
Plasma Concentrations ◽  
Cortisol Concentration ◽  
Control Fish ◽  
Chloride Solutions ◽  
Sodium Chloride Solutions ◽  
Plasma Cortisol Concentration

SUMMARY Plasma cortisol concentrations, measured by competitive protein-binding, were examined in intact and hypophysectomized goldfish (Carassius auratus L.) adapted to fresh water or to 210 mm-sodium chloride solutions. The mean plasma cortisol concentration of freshwater-adapted fish (6·6 ± 1·8 (s.e.m.) μg/100 ml plasma) increased after stress and intraperitoneal injections of mammalian corticotrophin. Hypophysectomy resulted in a reduction in plasma cortisol concentration to about 2 μg/100 ml plasma. Transfer of fish to sodium chloride solutions caused rapid, but transitory increases in the plasma cortisol concentrations in intact, but not in hypophysectomized fish. After 3 days in the sodium chloride solution the cortisol levels were similar to those of control fish kept in fresh water. The plasma concentrations of this corticosteroid in goldfish appear to be unrelated to external salinity, although a 'mineralocorticoid' action of the hormone cannot be excluded.

ADRENOCORTICAL FUNCTION TESTS IN DOGS WITH HYPERFUNCTIONING ADRENOCORTICAL TUMOURS

1979 ◽  
Vol 80 (3) ◽  
pp. 315-319 ◽  
Author(s):  
J. C. MEIJER ◽  
A. A. M. E. LUBBERINK ◽  
A. RIJNBERK ◽  
R. J. M. CROUGHS
Keyword(s):  
Plasma Concentration ◽  
Plasma Cortisol ◽  
Cortisol Concentration ◽  
Adrenocortical Function ◽  
Plasma Cortisol Concentration ◽  
Function Tests ◽  
Lysine Vasopressin ◽  
Adrenocortical Tumours ◽  
Adrenocortical Tumour

The response has been studied in nine dogs with hyperadrenocorticism due to adrenocortical tumours to the administration of dexamethasone, insulin, lysine-vasopressin and tetracosactide by measuring the changes in plasma cortisol concentration. Administration of dexamethasone did not produce a decrease in the plasma concentration of cortisol in any of these dogs. Administration of insulin caused slight increases in the plasma concentration of cortisol in four out of eight dogs. Lysine-vasopressin increased the plasma concentration of cortisol in eight out of nine dogs, three responded supranormally. Eight out of the nine dogs responded to tetracosactide administration, three responded supranormally. It is concluded that in the dog, in contrast to man, the lysine-vasopressin test cannot be used to differentiate between pituitary-dependent hyperadrenocorticism and hyperadrenocorticism due to an adrenocortical tumour. Apparently pituitary ACTH is not completely depleted in dogs with hyperfunctioning adrenocortical tumours.

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