scholarly journals Effects of Full Inhalation of Sevoflurane and Total Intravenous Anesthesia on Hemodynamics, Serum Myocardial Enzymes, and Myocardial Markers in Elderly Patients Undergoing Hysterectomy

2021 ◽  
Vol 2021 ◽  
pp. 1-5
Author(s):  
Xing Lan ◽  
Dong Yang ◽  
Shengnan Xie ◽  
Zhenghua Zhao
Keyword(s):  
Blood Pressure ◽  
Elderly Patients ◽  
Recovery Time ◽  
Plasma Cortisol ◽  
Cortisol Concentration ◽  
Intravenous Anesthesia ◽  
Plasma Cortisol Concentration ◽  
Group A ◽  
Group B ◽  
Myocardial Enzymes

Objective. To compare the effects of sevoflurane inhalation and intravenous anesthesia on hemodynamics, serum myocardial enzymes, and myocardial markers in elderly patients undergoing hysterectomy. Methods. Group A and group B were established randomly regarding a total of 126 elderly patients who underwent an elective hysterectomy. Patients in group A were given full anesthesia with sevoflurane, and patients in group B were given anesthesia with intravenous anesthesia. The operation time, anesthesia time, and recovery time in Postanesthesia Care Unit (PACU) were compared; plasma cortisol concentration, hemodynamics, serum myocardial enzymes, and myocardial markers were detected and compared between the two groups of patients before anesthesia ( T 0 ), after anesthesia ( T 1 ), and after surgery ( T 2 ). Results. Group A observed a longer extubation time and recovery time in PACU than group B ( P < 0.05 ). Results show a lower systolic blood pressure (SBP), diastolic blood pressure (DBP), heart rate (HR), and plasma cortisol concentration of T 1 by comparison with those of T 0 ( P < 0.05 ), but no significant difference remains in terms of intergroup SBP, DBP, and HR ( P > 0.05 ), and there was no interaction effect of groups and time ( P > 0.05 ). The two groups showed no great disparity in the levels of lactate dehydrogenase (LDH), aspartate transaminase (AST), creatine kinase (CK), and CK-MB as a subtype of CK before surgery between the two groups of patients ( P > 0.05 ). After surgery, LDH, AST, CK, and CK-MB levels in both groups were witnessed a surge, in which group A obtained higher levels of LDH, AST, CK, and CK-MB (all P < 0.05 ). Conclusion. Total intravenous anesthesia will not increase the hemodynamic fluctuation of elderly patients undergoing hysterectomy and can reduce the damage to the myocardium of patients with surgical trauma, which can protect the myocardium of elderly patients to a certain extent, so it can be adopted as the optimal anesthesia protocol for surgery.

scholarly journals Comparison of Balanced General and Total Intravenous Anaesthesia for Gasser Ganglion Percutaneous Balloon Microcompression for Trigeminal Neuralgia

2021 ◽  
pp. 1-3
Author(s):  
Patricia Heise ◽  
◽  
Marcos Baabor ◽  
Claudia Marin ◽  
◽  
...  
Keyword(s):  
Blood Pressure ◽  
Trigeminal Neuralgia ◽  
General Anaesthesia ◽  
Total Intravenous Anaesthesia ◽  
Intravenous Anesthesia ◽  
Intravenous Anaesthesia ◽  
Percutaneous Balloon ◽  
Group A ◽  
Group B ◽  
To Receive

Objective: To compare the effectiveness between balanced general anaesthesia and total intravenous anaesthesia for the hemodynamic control of patients undergoing percutaneous balloon microcompression of the Gasser’s ganglion in trigeminal neuralgia. Patients and methods: A retrospective trial was conducted in thirty patients with the diagnosis of essential trigeminal neuralgia, aged 37 to 82 years old, ASA I and II. The participants were randomly allocated in two groups: Group A, to receive balanced general anaesthesia (BGA) with isoflurane/fentanyl, or Group B, to receive total intravenous anesthesia (TIVA) with propofol/remifentanil. The systolic, diastolic and mean arterial blood pressure, heart rate and oximetry were measured at basal state, entrance to Meckel’s cavum and during the balloon compression. Statistical analysis with the Student T test for continuous quantitative variables and x2 (Chi square) for qualitative variables was performed. Results: The systolic blood pressure was significantly higher in group A at the moment of greatest stimulation. The technique propofol/remifentanil (group B) obtained better hemodynamic control and its management was easier. The incidence of bradycardia was similar in both groups and kept inverse relation with use of previous atropine. Conclusions: Total intravenous anesthesia (TIVA) is an attractive alternative to balanced general anesthesia due to the better hemodynamic response and the quick recovery that this technique offers. Moreover, Atropine use before the procedure is a measure that could benefit patients

scholarly journals Light synchronization of the circadian rhythm of blood pressure and plasma cortisol concentration in a case of Shy-Drager syndrome in apallic state.

1987 ◽  
Vol 76 (5) ◽  
pp. 718-724 ◽  
Author(s):  
Masanari KUNIMOTO ◽  
Yoshikazu UGAWA ◽  
Masanobu SAKAMOTO ◽  
Kiyoharu INOUE ◽  
Manabu SAKUTA
Keyword(s):  
Blood Pressure ◽  
Circadian Rhythm ◽  
Plasma Cortisol ◽  
Cortisol Concentration ◽  
Plasma Cortisol Concentration

scholarly journals Effect of Bone Cement Implantation on Haemodynamics in Elderly Patients and Preventive Measure in Cemented Hemiarthroplasty

2015 ◽  
Vol 2015 ◽  
pp. 1-6 ◽  
Author(s):  
Xiangbei Qi ◽  
Yingze Zhang ◽  
Jinshe Pan ◽  
Lijie Ma ◽  
Lin Wang ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Pulmonary Embolism ◽  
Elderly Patients ◽  
Bone Cement ◽  
Statistical Significance ◽  
Preventive Measure ◽  
Effective Measure ◽  
Marrow Cavity ◽  
Group A ◽  
Group B

This study was to investigate the influence of bone cement implantation on haemodynamics and the preventive effect of epinephrine hydrochloride on pulmonary embolism in elderly patients with cemented semihip replacement. 128 patients were retrospectively analyzed. The patients were treated with (group A, 64 cases) or without (group B, 64 cases) epinephrine hydrochloride saline. The monitoring indicators included systolic blood pressure (SBP), diastolic blood pressure (DBP), mean arterial pressure (MAP), heart rate (HR), and pulse oxygen saturation (SPO2). The indicators of the two groups were compared before and 1, 2, 3, 4, 5, 6, 7, 8, 9, and 10 minutes after bone cement implantation. Analysis of variance and SNK-q test were used for the statistical analysis. Blood pressure and SPO2of group B decreased with statistical difference (P<0.05) and HR increased without statistical significance, comparing with those of group A. In group A, SBP, DBP, MAP, HR, and SPO2after bone cement implantation did not change significantly at each time point comparing with before implantation (P>0.05). Bone cement implantation has significant influence on hemodynamics in elderly patients with hemiarthroplasty. Flushing the bone marrow cavity with saline epinephrine hydrochloride is an effective measure to reduce the incidence of bone cement pulmonary embolism.

scholarly journals Perioperative plasma cortisol concentration in the horse

1998 ◽  
Vol 69 (4) ◽  
Author(s):  
G.F. Stegmann ◽  
R.S. Jones
Keyword(s):  
Abdominal Surgery ◽  
Plasma Cortisol ◽  
Early Morning ◽  
Cortisol Concentration ◽  
Plasma Cortisol Concentration ◽  
Slow Decline ◽  
Prolonged Recovery ◽  
Group A ◽  
Surgical Preparation ◽  
Induction Of Anaesthesia

The cortisol response to anaesthesia and surgery was studied in 2 groups of horses undergoing either abdominal or non-abdominal surgery. The preoperative mean plasma cortisol concentration (pcc) of 381.7 nmol/ℓ (s.d. 254.7) was markedly higher in the abdominal group than the early-morning mean pcc of 115.6 nmol/ℓ (s.d. 78.4) in the non-abdominal group. During halothane anaesthesia and surgery themeanpcc increased significantly (p< 0.05) from the preoperativemeanof 119.2 to 215.9 nmol/ℓ (s.d. 79.8) after 30 min of surgery in the non-abdominal group. In the abdominal group a decrease occurred after induction of anaesthesia and surgical preparation, but increased during surgery to a mean pcc of 418.1 nmol/ℓ (s.d. 236.5). In the postoperative period a large decrease in the mean pcc occurred after 24 h in the abdominal group. It was only after 60 h that the pcc (153.2 nmol/ℓ ) equalled the pcc of the non-abdominal group (171.4 nmol/ℓ ) at 24 h . The slow decline over 60 h could be an indication of the prolonged recovery associated with abdominal surgery in the horse.

scholarly journals HEMODYNAMIC STABILITY AND RECOVERY TIME OF PROPOFOL AND SEVOFLURANE IN ULIN GENERAL HOSPITAL BANJARMASIN

2017 ◽  
Vol 13 (2) ◽  
pp. 153
Author(s):  
Rina Lesiana ◽  
Kenanga Marwan Sikumbang ◽  
Istiana Istiana ◽  
Oky Susianto ◽  
Erida Wydiamala
Keyword(s):  
Blood Pressure ◽  
General Hospital ◽  
Recovery Time ◽  
Well Being ◽  
Residual Effects ◽  
Hemodynamic Stability ◽  
Significant Difference ◽  
Group A ◽  
Bonferroni Test ◽  
Group B

Abstract: The main interest in general anesthesia is safety and the well being of the patient especially the stability of hemodynamic during induction until extubation. The most common causes of prolonging awakening are residual effects of drugs either anesthetics, sedatives, and analgesics. This study aimed to compare hemodynamic stability and recovery time between propofol and sevoflurane at Ulin General Hospital Banjarmasin. This was an observational analytic study conducted in July until November 2016 on 31 patients. The result showed that mean systolic blood pressure, diastolic blood pressure and heart rate for 90 minutes maintenance were no significant difference in group-A (propofol) compare with group-B (sevoflurane), post hoc Bonferroni test showing p>0.05. Mean recovery time to consciousness was faster in group-A (10,46 minutes) than group-B (15,59 minutes), there was no significant difference in two group. In conclusion, there was no significant difference in hemodynamic stability and recovery time between propofol and sevoflurane. Keywords: hemodynamic stability, recovery time, propofol, sevoflurane.

scholarly journals Comparison of Nasopharyngeal Airway Device and Nasal Oxygen Tube in Obese Patients Undergoing Intravenous Anesthesia for Gastroscopy: A Prospective and Randomized Study

2016 ◽  
Vol 2016 ◽  
pp. 1-6 ◽  
Author(s):  
Qiansong Xiao ◽  
Yingying Yang ◽  
Yinbin Zhou ◽  
Yan Guo ◽  
Xing Ao ◽  
...  
Keyword(s):  
Adverse Events ◽  
Recovery Time ◽  
Randomized Study ◽  
Assisted Ventilation ◽  
Airway Device ◽  
Obese Patients ◽  
Intravenous Anesthesia ◽  
Nasopharyngeal Airway ◽  
Group A ◽  
Group B

Objective. This prospective and randomized study evaluated the efficacy and safety of the nasopharyngeal airway relative to the nasal oxygen tube in obese patients undergoing painless gastroscopy.Materials and Methods. Obese patients (BMI≥28 kg/m2;n=260) were randomly and equally apportioned to the nasopharyngeal airway (Group A) or nasal oxygen tube (Group B) group. Three patients were excluded due to failure of insertion of the nasopharyngeal airway. The duration of endoscopy, anesthetic dose, recovery time, and adverse events were recorded. The satisfaction of the anesthetist, physicians, and patient was scored.Results. The SpO2reduction was significantly less in Group A than in Group B. Use of a respirator for assisted ventilation occurred significantly less in Group A. The groups were similar regarding mean arterial pressure, heart rate, anesthetic dose, duration of gastroscopy, recovery time, and adverse events. Satisfaction of the physician and anesthetist was greater in Group A; the groups were similar in patient satisfaction.Conclusions. Use of the nasopharyngeal airway for obese patients during painless gastroscopy resulted in less SpO2reduction relative to the nasal oxygen tube. Altogether, it is a safe and effective device for obese patients undergoing painless gastroscopy.

Bioinformatics Study on Serum Triglyceride Levels for Analysis of a Potential Risk Factor Affecting Blood Pressure Variability

2019 ◽  
Vol 14 (5) ◽  
pp. 376-385 ◽  
Author(s):  
Lin Xu ◽  
Jiangming Huang ◽  
Zhe Zhang ◽  
Jian Qiu ◽  
Yan Guo ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Systolic Blood Pressure ◽  
Blood Pressure Variability ◽  
Partial Correlation ◽  
Pearson Correlation ◽  
Target Organ Damage ◽  
Serum Triglyceride ◽  
Hypertensive Patients ◽  
Group A ◽  
Group B

Objective: The purpose of this study was to establish whether Triglycerides (TGs) are related to Blood Pressure (BP) variability and whether controlling TG levels leads to better BP variability management and prevents Cardiovascular Disease (CVD). Methods: In this study, we enrolled 106 hypertensive patients and 80 non-hypertensive patients. Pearson correlation and partial correlation analyses were used to define the relationships between TG levels and BP variability in all subjects. Patients with hypertension were divided into two subgroups according to TG level: Group A (TG<1.7 mmol/L) and Group B (TG>=1.7 mmol/L). The heterogeneity between the two subgroups was compared using t tests and covariance analysis. Results: TG levels and BP variability were significantly different between the hypertensive and non-hypertensive patients. Two-tailed Pearson correlation tests showed that TG levels are positively associated with many BP variability measures in all subjects. After reducing other confounding factors, the partial correlation analysis revealed that TG levels are still related to the Standard Deviation (SD), Coefficient of Variation (CV) of nighttime systolic blood pressure and CV of nighttime diastolic blood pressure, respectively (each p<0.05). In the subgroups, group A had a lower SD of nighttime Systolic Blood Pressure (SBP_night_SD; 11.39±3.80 and 13.39±4.16, p=0.011), CV of nighttime systolic blood pressure (SBP_night_CV; 0.09±0.03 and 0.11±0.03, p=0.014) and average real variability of nighttime systolic blood pressure (SBP_night_ARV; 10.99±3.98 and 12.6±3.95, p=0.024) compared with group B, even after adjusting for age and other lipid indicators. Conclusion: TG levels are significantly associated with BP variability and hypertriglyceridemia, which affects blood pressure variability before causing target organ damage.

The Effect of Prophylactic Ephedrine on Systemic Hypotension Caused by Induction of Anaesthesia with Propofol and Sufentanil in Elderly Hypertensive Patients: A Prospective Randomized, Double-blind Placebo-controlled Clinical Trial

2020 ◽  
Keyword(s):  
Blood Pressure ◽  
General Anesthesia ◽  
Normal Saline ◽  
Saline Group ◽  
Normal Saline Group ◽  
Hypertensive Patients ◽  
Group A ◽  
Elderly Hypertensive ◽  
Elderly Hypertensive Patients ◽  
Group B

Objective: To study the effectiveness of prophylactic ephedrine to prevent hypotension caused by induction of anesthesia with propofol and sufentanil in elderly hypertensive patients. Methodology: 70 elderly ASA grade II-III hypertensive patients undergoing elective general anesthesia were randomized into two groups to receive either intravenous ephedrine,100 ug/kg in 5ml normal saline (Group B), or an equal volume of normal saline (Group A) before induction. Systolic Blood Pressure (SBP), Diastolic Blood Pressure (DBP) and Heart Rate (HR) were recorded at T0 (after entry to the operating room), T1 (1 min after induction), T2 (2 min after induction), T3 ( 3 min after induction), T4 (4 min after induction), T5 (when intubated), T6 (2 min after intubation), and T7 (at the start of the procedure), as well as the incidence of hypotension and bradycardia. Results: SBP, DBP and HR were not significantly different at T0 and were significantly different at T1 to T7 after anesthesia induction. There were statistically significant effect on hypotension and bradycardia between the two groups and group B have a lower risk of hypotension and bradycardia relative to group A. SBP and DBP decreased significantly after induction in both groups. HR decreased significantly in group A while increased in group B. Conclusion: Ephedrine pretreatment can minimize hypotension and bradycardia caused by propofol and sufentanil during the induction of general anesthesia in elderly patients with hypertension.

Intrauterine growth restriction delays surfactant protein maturation in the sheep fetus

2010 ◽  
Vol 298 (4) ◽  
pp. L575-L583 ◽  
Author(s):  
Sandra Orgeig ◽  
Tamara A. Crittenden ◽  
Ceilidh Marchant ◽  
I. Caroline McMillen ◽  
Janna L. Morrison
Keyword(s):  
Mrna Expression ◽  
Plasma Cortisol ◽  
Surfactant Protein ◽  
Cortisol Concentration ◽  
Plasma Catecholamine ◽  
Fetal Sheep ◽  
C Protein ◽  
Intrauterine Growth ◽  
Plasma Cortisol Concentration ◽  
The Impact

Pulmonary surfactant is synthesized by type II alveolar epithelial cells to regulate the surface tension at the air-liquid interface of the air-breathing lung. Developmental maturation of the surfactant system is controlled by many factors including oxygen, glucose, catecholamines, and cortisol. The intrauterine growth-restricted (IUGR) fetus is hypoxemic and hypoglycemic, with elevated plasma catecholamine and cortisol concentrations. The impact of IUGR on surfactant maturation is unclear. Here we investigate the expression of surfactant protein (SP) A, B, and C in lung tissue of fetal sheep at 133 and 141 days of gestation (term 150 ± 3 days) from control and carunclectomized Merino ewes. Placentally restricted (PR) fetuses had a body weight <2 SD from the mean of control fetuses and a mean gestational PaO2<17 mmHg. PR fetuses had reduced absolute, but not relative, lung weight, decreased plasma glucose concentration, and increased plasma cortisol concentration. Lung SP-A, -B, and -C protein and mRNA expression was reduced in PR compared with control fetuses at both ages. SP-B and -C but not SP-A mRNA expression and SP-A but not SP-B or -C protein expression increased with gestational age. Mean gestational PaO2was positively correlated with SP-A, -B, and -C protein and SP-B and -C mRNA expression in the younger cohort. SP-A and -B gene expression was inversely related to plasma cortisol concentration. Placental restriction, leading to chronic hypoxemia and hypercortisolemia in the carunclectomy model, results in significant inhibition of surfactant maturation. These data suggest that IUGR fetuses are at significant risk of lung complications, especially if born prematurely.

ANTIDIURETIC HORMONE AND CORTICOTROPHIN RELEASE IN MAN

1960 ◽  
Vol 21 (2) ◽  
pp. 171-176 ◽  
Author(s):  
S. SHUSTER
Keyword(s):  
Antidiuretic Hormone ◽  
Plasma Cortisol ◽  
Cortisol Concentration ◽  
Release Factor ◽  
Similar Increase ◽  
Rapid Infusion ◽  
Experimental Procedure ◽  
Plasma Cortisol Concentration ◽  
Corticotrophin Release Factor ◽  
Patients With Diabetes

SUMMARY Plasma cortisol concentrations increased after injections of nicotine. This increase was variable and was no greater than that seen after substitution of normal saline for nicotine. Plasma cortisol concentrations did not increase after nicotine in patients with hypopituitarism and after inhibition of corticotrophin release with triamcinolone. It is concluded that the increased plasma cortisol concentration after injection of nicotine was due to non-specific pituitary stimulation associated with the experimental procedure and not due to any direct effect of the nicotine. Nicotine resulted in a similar increase in plasma cortisol in four patients with diabetes insipidus. Neither rapid infusion of hypertonic mannitol nor ingestion of ethanol had a consistent effect on the plasma cortisol concentration. It is therefore concluded that the antidiuretic hormone is not the 'corticotrophin release factor' in man.

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