scholarly journals Study on the role of tissue thromboplastin in the formation of thrombosis.

1987 ◽  
Vol 76 (1) ◽  
pp. 2-7
Author(s):  
Norio KOBAYASHI
Keyword(s):  
Tissue Thromboplastin

The Role of Vitamins in Hemostasis

1975 ◽  
Vol 33 (02) ◽  
pp. 191-198
Author(s):  
Armand J Quick
Keyword(s):  
Vitamin K ◽  
Physiological Mechanism ◽  
Factor Vii ◽  
Clotting Factors ◽  
The Third ◽  
Abnormal Bleeding ◽  
Vitamin Q ◽  
Tissue Thromboplastin ◽  
And Control

SummaryThe physiological mechanism to prevent and control abnormal bleeding is dependent on three vitamins (C, K, and Q). Two of these are unequivocally established as essential for hemostasis while the existence of the third (Q) is supported by experimental evidence and by clinical and therapeutic observations (Quick 1972; Quick 1974). The interrelationship of these three vitamins has remained moot except for clue observations. Both vitamins C and K have a key structure in their molecules which supplies a redox mechanism, ascorbic acid and 2-methyl, 1,4-naphthoquinone, respectively. Both vitamins are concerned with growth. Lack of vitamin C, which clinically is the basic defect in scurvy, does not appear to cause a defect in blood coagulation while vitamin K affects the clotting mechanism by being essential for the production of four distinct clotting factors: prothrombin, factors VII, IX and X.In this presentation an attempt is made to correlate the action of the vitamin K-dependent clotting factors grouping them in a diagram to show how two systems of thrombin formation exist, one being essentially intrinsic, the second extrinsic requiring tissue thromboplastin and factor VII. The possible interlocking of vitamin Q in this mechanism is presented.

The Role of Factor IX in Tissue Thromboplastin Induced Coagulation

1982 ◽  
Vol 48 (01) ◽  
pp. 054-058 ◽  
Author(s):  
A M H P van den Besselaar ◽  
I E Ram ◽  
G H J Alderkamp ◽  
R M Bertina
Keyword(s):  
Human Factor ◽  
Factor Ix ◽  
Factor Vii ◽  
Factor Xii ◽  
Factor Xi ◽  
Proteolytic Activation ◽  
Human Factor Ix ◽  
Tissue Thromboplastin ◽  
The Difference

SummaryTissue thromboplastin apoprotein was partially purified from human brain. The apoprotein was recombined with mixed phospholipids to yield active thromboplastin. The recombined thromboplastin induced proteolytic activation of isolated human factor IX in the presence of factor VII and Ca2+. The clotting times of various deficient plasmas were determined as a function of apoprotein concentration, keeping the phospholipid concentration constant. The clotting times of a factor XII-deficient plasma were the same as those of a factor XII/factor IX-deficient plasma, except at very low apoprotein concentrations. However, under those conditions the difference in clotting times was independent of the presence of anti-factor VII serum. Similar observations were made for factor XI-deficient plasma in comparison with factor XI/factor IX-deficient plasma. These results indicate that activation of factor IX by factor VII/tissue thromboplastin does not significantly contribute to plasma coagulation.

Assay and Content of Tissue Thromboplastin in Different Organs*

1965 ◽  
Vol 14 (03/04) ◽  
pp. 401-416 ◽  
Author(s):  
T Astrup
Keyword(s):  
Local Repair ◽  
Tissue Thromboplastin ◽  
Tissue Injuries ◽  
Animal Organs

Summary1. The assay of thromboplastin in tissues in terms of units of concentration by means of the double logarithmic graph is described and discussed. The significance of comparing thromboplastin in terms of concentrations and not in terms of activities is explained.2. The concentration of thromboplastin in some human and animal organs is estimated. Great variations are encountered in concentrations. The differences are larger than is generally assumed from activity assays only. The possible role of these differences in the local repair of tissue injuries as part of the hemostatic balance is mentioned.

The Role of Tissue Thromboplastin in the Development of DIC Accompanying Neoplastic Diseases

2015 ◽  
pp. 23-39 ◽  
Author(s):  
Hidemi Gonmori ◽  
Tadashi Maekawa ◽  
Norio Kobayashi ◽  
Hiroshi Tanaka ◽  
Hiroyuki Tsukada ◽  
...  
Keyword(s):  
Neoplastic Diseases ◽  
Tissue Thromboplastin
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