The Role of Tissue Thromboplastin in the Development of DIC Accompanying Neoplastic Diseases

2015 ◽  
pp. 23-39 ◽  
Author(s):  
Hidemi Gonmori ◽  
Tadashi Maekawa ◽  
Norio Kobayashi ◽  
Hiroshi Tanaka ◽  
Hiroyuki Tsukada ◽  
...  
Keyword(s):  
Neoplastic Diseases ◽  
Tissue Thromboplastin

scholarly journals Ovulation, A Sign of Health

2017 ◽  
Vol 84 (4) ◽  
pp. 343-355 ◽  
Author(s):  
Pilar Vigil ◽  
Carolina Lyon ◽  
Betsi Flores ◽  
Hernán Rioseco ◽  
Felipe Serrano
Keyword(s):  
Health Status ◽  
Healthcare Providers ◽  
Diagnosis And Treatment ◽  
Medical Professionals ◽  
Endocrine Disorders ◽  
Neoplastic Diseases ◽  
Intrauterine Life ◽  
Medical Healthcare ◽  
Hormonal Levels

The concept of the ovarian continuum can be understood as a process that occurs during a woman's lifetime and begins during intrauterine life with fertilization. Women start their reproductive years with approximately five hundred thousand follicles containing oocytes, of which only around five hundred will be released during ovulation. Ovulation has been recognized as an event linked with reproduction; however, recent evidence supports the role of ovulation as a sign of health. The use of biomarkers that help women recognize ovulation enables them to identify their health status. This knowledge helps medical healthcare providers in the prevention, diagnosis, and treatment of different pathologies related with endocrine disorders, gynecological abnormalities, autoimmune, genetic, and neoplastic diseases, as well as pregnancy-related issues. The knowledge of the ovarian continuum and the use of biomarkers to recognize ovulation should be considered a powerful tool for women and medical professionals. Summary The ovarian continuum is a process that occurs during a woman's lifetime. It begins during intrauterine life with fertilization and ends with menopause. This process can be greatly affected by different conditions such as changes in hormonal levels and illnesses. Therefore, understanding and promoting the knowledge and use of biomarkers of ovulation in women is a key aspect to consider when evaluating their health status. The knowledge and education about the ovarian continuum should be taken into account as a powerful tool for women and medical professionals.

The Role of Vitamins in Hemostasis

1975 ◽  
Vol 33 (02) ◽  
pp. 191-198
Author(s):  
Armand J Quick
Keyword(s):  
Vitamin K ◽  
Physiological Mechanism ◽  
Factor Vii ◽  
Clotting Factors ◽  
The Third ◽  
Abnormal Bleeding ◽  
Vitamin Q ◽  
Tissue Thromboplastin ◽  
And Control

SummaryThe physiological mechanism to prevent and control abnormal bleeding is dependent on three vitamins (C, K, and Q). Two of these are unequivocally established as essential for hemostasis while the existence of the third (Q) is supported by experimental evidence and by clinical and therapeutic observations (Quick 1972; Quick 1974). The interrelationship of these three vitamins has remained moot except for clue observations. Both vitamins C and K have a key structure in their molecules which supplies a redox mechanism, ascorbic acid and 2-methyl, 1,4-naphthoquinone, respectively. Both vitamins are concerned with growth. Lack of vitamin C, which clinically is the basic defect in scurvy, does not appear to cause a defect in blood coagulation while vitamin K affects the clotting mechanism by being essential for the production of four distinct clotting factors: prothrombin, factors VII, IX and X.In this presentation an attempt is made to correlate the action of the vitamin K-dependent clotting factors grouping them in a diagram to show how two systems of thrombin formation exist, one being essentially intrinsic, the second extrinsic requiring tissue thromboplastin and factor VII. The possible interlocking of vitamin Q in this mechanism is presented.

The Role of Factor IX in Tissue Thromboplastin Induced Coagulation

1982 ◽  
Vol 48 (01) ◽  
pp. 054-058 ◽  
Author(s):  
A M H P van den Besselaar ◽  
I E Ram ◽  
G H J Alderkamp ◽  
R M Bertina
Keyword(s):  
Human Factor ◽  
Factor Ix ◽  
Factor Vii ◽  
Factor Xii ◽  
Factor Xi ◽  
Proteolytic Activation ◽  
Human Factor Ix ◽  
Tissue Thromboplastin ◽  
The Difference

SummaryTissue thromboplastin apoprotein was partially purified from human brain. The apoprotein was recombined with mixed phospholipids to yield active thromboplastin. The recombined thromboplastin induced proteolytic activation of isolated human factor IX in the presence of factor VII and Ca2+. The clotting times of various deficient plasmas were determined as a function of apoprotein concentration, keeping the phospholipid concentration constant. The clotting times of a factor XII-deficient plasma were the same as those of a factor XII/factor IX-deficient plasma, except at very low apoprotein concentrations. However, under those conditions the difference in clotting times was independent of the presence of anti-factor VII serum. Similar observations were made for factor XI-deficient plasma in comparison with factor XI/factor IX-deficient plasma. These results indicate that activation of factor IX by factor VII/tissue thromboplastin does not significantly contribute to plasma coagulation.

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