scholarly journals The Ability of a Single Serum Progesterone Measurement to Predict the Prognosis of First Trimester Pregnancy

2019 ◽  
pp. 1
Author(s):  
Mehmet Nafi Sakar ◽  
Deniz Balsak ◽  
Sureyya Demir ◽  
Mehmet Sukru Budak ◽  
Ali Emre Tahaoglu ◽  
...  
Keyword(s):  
Spontaneous Abortion ◽  
Serum Levels ◽  
First Trimester ◽  
Tertiary Hospital ◽  
Case Group ◽  
Serum Progesterone ◽  
Predictive Values ◽  
Elisa System ◽  
First Trimester Pregnancy ◽  
Trimester Pregnancy

<p><strong>OBJECTIVE:</strong> There are cases where ultrasonographic evaluation is inadequate in determining first-trimester healthy pregnancy. In these cases, both the patient and the clinician are involved in a worrying expectation. The single serum progesterone measurement was tried to predict pregnancy prognosis in short time period. This study evaluated the predictive value of a single serum progesterone measurement in first-trimester pregnancy loss.</p><p><strong>STUDY DESIGN:</strong> A prospective case-control study was conducted between July 2013 and July 2014 in Tertiary Hospital. The study compared 106 patients with threatened abortion (vaginal bleeding or spotting) before 13 weeks of gestation with 110 healthy control pregnancies. Samples of serum progesterone were obtained on the day each patient was admitted to the hospital. A Beckman-Coulter macro-Enzyme-linked immunoassay (ELISA) system was used to measure serum levels of progesterone (Beckman-Coulter, Ireland).</p><p><strong>RESULTS:</strong> Progesterone levels were measured when the patients first visited the hospital and they were followed until the end of the first trimester. Progesterone levels differed significantly (p=0.013) between the two groups. The spontaneous abortion rate was significantly (p=0.044) higher in the case group. Progesterone levels differed significantly (p=0.001) between ongoing pregnancy and spontaneous abortion groups. Using a cut-off level of 10.7 ng/mL, the sensitivity, specificity, and positive and negative predictive values were 92.1%, 44%, 92.6%, and 42.3%, respectively, for viable pregnancies.</p><p><strong>CONCLUSION:</strong> A single measurement of progesterone levels in serum can predict the prognosis of a viable first-trimester pregnancy, while it is less effective for identifying non-viable pregnancies.</p>

scholarly journals Baseline Levels of Serum Progesterone and the First Trimester Pregnancy Outcome in Women with Threatened Abortion: A Retrospective Cohort Study

2020 ◽  
Vol 2020 ◽  
pp. 1-8
Author(s):  
Yongshi Deng ◽  
Chi Chen ◽  
Siyun Chen ◽  
Guanyan Mai ◽  
Xiuping Liao ◽  
...  
Keyword(s):  
Cohort Study ◽  
Pregnancy Outcome ◽  
Retrospective Cohort Study ◽  
Retrospective Cohort ◽  
First Trimester ◽  
Outcome Variable ◽  
Serum Progesterone ◽  
First Trimester Pregnancy ◽  
Trimester Pregnancy ◽  
Threatened Abortion

Objective. The relationship between serum progesterone and the first trimester pregnancy outcome of threatened abortion is still controversial. Therefore, we aimed to further study the association between these two parameters. Methods. The present study is an observational retrospective cohort study. A total of 726 participants who had threatened abortion from a hospital in Guangdong, China, were included in this study from 17th August 2011 to 30th October 2018. The exposure variable and the outcome variable were serum progesterone measured at baseline and early pregnancy outcome, respectively. Covariates involved in this study included patients’ basic demographics, obstetric history, and clinical information. Results. A negative association and a saturation effect were detected between serum progesterone and the first trimester pregnancy outcome. When progesterone <90.62 nmol/L, an increase in 1 nmol/L of serum progesterone was associated with 3% decrease of the risk of miscarriage (OR: 0.97, 95% CI: 0.95-0.98). Conclusion. There was a greater risk of abortion when the serum progesterone level was less than 90.62 nmol/L. Our findings can better assist the clinician in understanding patients’ conditions and making medical decisions.

scholarly journals Impact of High-normal Serum TSH with First Trimester Pregnancy Loss: A Case-control Study in Tertiary Care Hospitals in Bangladesh

2018 ◽  
Vol 1 (1) ◽  
pp. 29-35
Author(s):  
Yisrat Jahan ◽  
M Anwar Hussain ◽  
Rezaul Karim Kazal ◽  
Mohammad Akhteruzzaman ◽  
Rifat Jahan
Keyword(s):  
Pregnancy Loss ◽  
Tertiary Care ◽  
First Trimester ◽  
Normal Serum ◽  
Control Group ◽  
Case Group ◽  
First Trimester Pregnancy ◽  
Trimester Pregnancy ◽  
Tertiary Care Hospitals ◽  
Serum Tsh

The relationship between existing thyroid autoimmunity and the probability of spontaneous abortion has been the subject of a number of studies. In this study, we evaluate the impact of `high normal' serum TSH levels (2.5-5.0 mlU/L) on first trimester pregnancy loss in anti-TPO Ab negative women in Bangladesh. Specifically, we wanted to know the average serum TSH levels for women who had a miscarriage (case group) and who did not have a miscarriage (control group) during the first trimester of pregnancy. Unmatched case-control study involving 119 women in their first trimester was conducted during July 2011 to June 2012 in three tertiary care hospitals in Bangladesh. We found average TSH level for the control group (1.42$\pm$0.86 mlU/L) to be lower than the average for the case group (1.74$\pm$1.15 mlU/L). However, we did not find statistically significant association between the serum TSH level and first-trimester pregnancy loss. The findings of this study will provide a baseline for future studies on this topic involving Bangladeshi women. In addition, our study adds to the growing discussion on redefining the lower limit for the `high normal' serum TSH level among the anti-TPO Ab negative women.

scholarly journals Association of TSH level above 2.1 mlU/L and first trimester pregnancy loss in anti-TPO antibody negative women

2015 ◽  
Author(s):  
Yisrat Jahan ◽  
Enayetur Raheem ◽  
Mohammad Akteruzzaman ◽  
M Anwar Hussain ◽  
Rezaul Karim ◽  
...  
Keyword(s):  
Pregnancy Loss ◽  
Local Level ◽  
First Trimester ◽  
Control Group ◽  
Case Group ◽  
Thyroid Autoantibody ◽  
First Trimester Pregnancy ◽  
Trimester Pregnancy ◽  
Group I ◽  
First Trimester Of Pregnancy

Although the exact level of TSH that is indicative of risk of pregnancy loss is not known, a number of studies have suggested a range of values for TSH level that are associated with first trimester pregnancy loss. We conducted an unmatched case-control study to test if a TSH level above 2.1 mlU/L is associated with first trimester pregnancy loss in anti-TPO antibody negative women. We found relatively higher number of women in the case group (18) whose TSH level was above 2.1 mlU/L compared to 7 women in control group. When considered patients in Group I (TSH ≤2.1 mlU/L), 45.74% had miscarriage while 54.26% did not have miscarriage within first trimester of pregnancy. Among the Group II patients (TSH >2.1 mlU/L), 78% had miscarriage and 28% did not have miscarriage. Noticeably there is a larger proportion of miscarriage among the women with TSH level above 2.1 mlU/L. The association between TSH level and first trimester pregnancy loss was statistically significant (p=.0196). From the multivariate analysis, odds ratio for TSH level (OR 4.0, 95% CI: 1.44-11.16) indicates that odds of having miscarriage whose TSH level is above 2.1 mlU/L is 4 times compared to those with TSH level below 2.1 mlU/L after adjusting for the effects of age and BMI. At a global level, the findings of this study provide evidence to the existing discussion on redefining the upper limit of TSH level that is related to first trimester pregnancy loss. At the local level, the results will have direct implication in facilitating management of future pregnancies particularly during the first trimester among Bangladeshi thyroid autoantibody negative women.

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