scholarly journals Association of TSH level above 2.1 mlU/L and first trimester pregnancy loss in anti-TPO antibody negative women

2015 ◽  
Author(s):  
Yisrat Jahan ◽  
Enayetur Raheem ◽  
Mohammad Akteruzzaman ◽  
M Anwar Hussain ◽  
Rezaul Karim ◽  
...  
Keyword(s):  
Pregnancy Loss ◽  
Local Level ◽  
First Trimester ◽  
Control Group ◽  
Case Group ◽  
Thyroid Autoantibody ◽  
First Trimester Pregnancy ◽  
Trimester Pregnancy ◽  
Group I ◽  
First Trimester Of Pregnancy

Although the exact level of TSH that is indicative of risk of pregnancy loss is not known, a number of studies have suggested a range of values for TSH level that are associated with first trimester pregnancy loss. We conducted an unmatched case-control study to test if a TSH level above 2.1 mlU/L is associated with first trimester pregnancy loss in anti-TPO antibody negative women. We found relatively higher number of women in the case group (18) whose TSH level was above 2.1 mlU/L compared to 7 women in control group. When considered patients in Group I (TSH ≤2.1 mlU/L), 45.74% had miscarriage while 54.26% did not have miscarriage within first trimester of pregnancy. Among the Group II patients (TSH >2.1 mlU/L), 78% had miscarriage and 28% did not have miscarriage. Noticeably there is a larger proportion of miscarriage among the women with TSH level above 2.1 mlU/L. The association between TSH level and first trimester pregnancy loss was statistically significant (p=.0196). From the multivariate analysis, odds ratio for TSH level (OR 4.0, 95% CI: 1.44-11.16) indicates that odds of having miscarriage whose TSH level is above 2.1 mlU/L is 4 times compared to those with TSH level below 2.1 mlU/L after adjusting for the effects of age and BMI. At a global level, the findings of this study provide evidence to the existing discussion on redefining the upper limit of TSH level that is related to first trimester pregnancy loss. At the local level, the results will have direct implication in facilitating management of future pregnancies particularly during the first trimester among Bangladeshi thyroid autoantibody negative women.

scholarly journals Impact of High-normal Serum TSH with First Trimester Pregnancy Loss: A Case-control Study in Tertiary Care Hospitals in Bangladesh

2018 ◽  
Vol 1 (1) ◽  
pp. 29-35
Author(s):  
Yisrat Jahan ◽  
M Anwar Hussain ◽  
Rezaul Karim Kazal ◽  
Mohammad Akhteruzzaman ◽  
Rifat Jahan
Keyword(s):  
Pregnancy Loss ◽  
Tertiary Care ◽  
First Trimester ◽  
Normal Serum ◽  
Control Group ◽  
Case Group ◽  
First Trimester Pregnancy ◽  
Trimester Pregnancy ◽  
Tertiary Care Hospitals ◽  
Serum Tsh

The relationship between existing thyroid autoimmunity and the probability of spontaneous abortion has been the subject of a number of studies. In this study, we evaluate the impact of `high normal' serum TSH levels (2.5-5.0 mlU/L) on first trimester pregnancy loss in anti-TPO Ab negative women in Bangladesh. Specifically, we wanted to know the average serum TSH levels for women who had a miscarriage (case group) and who did not have a miscarriage (control group) during the first trimester of pregnancy. Unmatched case-control study involving 119 women in their first trimester was conducted during July 2011 to June 2012 in three tertiary care hospitals in Bangladesh. We found average TSH level for the control group (1.42$\pm$0.86 mlU/L) to be lower than the average for the case group (1.74$\pm$1.15 mlU/L). However, we did not find statistically significant association between the serum TSH level and first-trimester pregnancy loss. The findings of this study will provide a baseline for future studies on this topic involving Bangladeshi women. In addition, our study adds to the growing discussion on redefining the lower limit for the `high normal' serum TSH level among the anti-TPO Ab negative women.

scholarly journals SARS-CoV-2 in first trimester pregnancy – does it affect the fetus?

2020 ◽  
Author(s):  
Nina la Cour Freiesleben ◽  
Pia Egerup ◽  
Kathrine Vauvert Römmelmayer Hviid ◽  
Elin Rosenbek Severinsen ◽  
Astrid Marie Kolte ◽  
...  
Keyword(s):  
Pregnant Women ◽  
Pregnancy Loss ◽  
Viral Infections ◽  
First Trimester ◽  
Nuchal Translucency ◽  
Grey Zone ◽  
First Trimester Pregnancy ◽  
Trimester Pregnancy ◽  
First Trimester Of Pregnancy ◽  
Test Serum

AbstractBackgroundSeveral viral infections are known to be harmful to the fetus in the first trimester of pregnancy and can cause increased nuchal translucency thickness and pregnancy loss. Currently, no evidence exists regarding possible effects of SARS-CoV-2 in first trimester pregnancies.MethodsCohort 1 included pregnant women with a double test taken between Feb. 17 and Apr. 23, 2020, during the SARS-CoV-2 epidemic peak in Denmark. The double test was taken as part of the first trimester risk assessment. Cohort 2 included women with a first trimester pregnancy loss before double test. Serum from the double test or from a blood sample, in case of pregnancy loss, was analyzed for SARS-CoV-2 antibodies. The results were correlated to the nuchal translucency thickness and the number of pregnancy losses.ResultsIn total, 1,019 pregnant women with double test and 36 women with pregnancy loss participated in the study. Thirty (2.9%) women had SARS-CoV-2 antibodies in the serum from the double test. All women with pregnancy loss prior to the double test were negative for SARS-CoV-2 antibodies. There were no significant differences in nuchal translucency thickness for women testing positive (n=14) versus negative (p=0.20) or grey zone (n=16) versus negative (p=0.28). In total, 54 women experienced a pregnancy loss of whom two had grey zone or positive SARS-CoV-2 antibodies.ConclusionMaternal SARS-CoV-2 infection did not seem harmful in first trimester pregnancies. Infection had no effect on the nuchal translucency thickness and women with SARS-CoV-2 antibodies were not overrepresented among women with pregnancy loss.

scholarly journals Incidental Endometrial Carcinoma Diagnosed at First Trimester Pregnancy Loss: A Case Report

2014 ◽  
Vol 36 (11) ◽  
pp. 1010-1013 ◽  
Author(s):  
Lana Saciragic ◽  
Christopher G. Ball ◽  
Shahidul Islam ◽  
Michael Fung-Kee-Fung
Keyword(s):  
Case Report ◽  
Endometrial Carcinoma ◽  
Pregnancy Loss ◽  
First Trimester ◽  
First Trimester Pregnancy ◽  
Trimester Pregnancy

Extensive Thrombosis and First-Trimester Pregnancy Loss Caused by Sticky Platelet Syndrome

2011 ◽  
Vol 117 (2, Part 2) ◽  
pp. 501-503 ◽  
Author(s):  
Martha W. F. Rac ◽  
Natalie Minns Crawford ◽  
Kevin C. Worley
Keyword(s):  
Pregnancy Loss ◽  
First Trimester ◽  
First Trimester Pregnancy ◽  
Trimester Pregnancy

scholarly journals Adjuvant acupuncture reduces first trimester pregnancy loss after IVF

2012 ◽  
Vol 02 (03) ◽  
pp. 283-286 ◽  
Author(s):  
Naseem M. Khorram ◽  
Susan Horton ◽  
Vicken Sahakian ◽  
Richard Chacon ◽  
Omid Khorram
Keyword(s):  
Pregnancy Loss ◽  
First Trimester ◽  
First Trimester Pregnancy ◽  
Trimester Pregnancy

scholarly journals EMBRYONIC HEART RATE: A PROGNOSTIC FACTOR OF FIRST TRIMESTER PREGNANCY OUTCOME

2021 ◽  
Vol 5 (2) ◽  
Author(s):  
Chetana Choudhary ◽  
Lata Rajoria ◽  
Chelsae Kuntal ◽  
Sunita Hemani ◽  
Aditi Bansal ◽  
...  
Keyword(s):  
Heart Rate ◽  
Gestational Age ◽  
Pregnancy Loss ◽  
Cardiac Activity ◽  
First Trimester ◽  
Good Prognosis ◽  
Embryonic Heart ◽  
Transvaginal Sonography ◽  
First Trimester Pregnancy ◽  
Trimester Pregnancy

Introduction: The earliest proof of a viable pregnancy is obtained when cardiac activity of the embryo can be observed. Transvaginal sonography can accurately demonstrate embryonic heart rate at 6 weeks of gestational age by using M-mode transvaginal sonography. Slow embryonic heart rate at 6-7 weeks of gestational age is associated with high rate of first trimester pregnancy loss. AIM:  The study was aimed to evaluate the role of embryonic heart rate (EHR) of early pregnancies as predictive factor of adverse outcome at end of first trimester of pregnancy. Methods: This observational study was conducted in the Department of Obstetrics and Gynecology Zenana Hospital, SMS Medical College, Jaipur. It included 300 pregnant women between 6 weeks to 9 weeks of gestational age attending antenatal OPD. Embryonic heart rate was measured by transvaginal sonography. Embryonic heart rate was classified as slow, if it was fewer than 110 beats/ mint or outcome was measured as occurance of spontaneous pregnancy loss prior to 12 weeks. Results: Out of 300 cases, 290 (96.67%) had embryonic heart rate ?100 beats per minutes and 10(3.33%) had embryonic heart rate <100 beats per minutes. Out of these 290, (Embryonic heart rate ?100 beats per minutes), 284 (97.93%) had good prognosis and 6 (2.07%) had abortion. In 10 women (Embryonic heart rate <100 beats per minutes), 3 (30.00%) had good prognosis and 7 (70.00%) had abortion. This observation was statistically significant. Conclusion: Slow embryonic heart rate on ultrasonography reduced the success of pregnancy and may lead to abortion. Keywords: Embryonic heart rate, Ultrasonography, Early pregnancy loss

First trimester pregnancy loss after fresh and frozen in vitro fertilization cycles

2016 ◽  
Vol 105 (3) ◽  
pp. 722-728 ◽  
Author(s):  
Heather Hipp ◽  
Sara Crawford ◽  
Jennifer F. Kawwass ◽  
Jeani Chang ◽  
Dmitry M. Kissin ◽  
...  
Keyword(s):  
In Vitro Fertilization ◽  
Pregnancy Loss ◽  
First Trimester ◽  
Vitro Fertilization ◽  
First Trimester Pregnancy ◽  
Trimester Pregnancy
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