scholarly journals Short Term Alterations of Hormone Profile Following Oocyte Pick-Up in Women with Polycystic Ovarian Syndrome to Assess the Effect of Multiple Needle Entries Into the Ovarian Cortex and Stroma

2018 ◽  
Vol 24 (1) ◽  
pp. 17
Author(s):  
Enis Ozkaya ◽  
Cigdem Abide Yayla ◽  
Semra Kayatas Eser ◽  
Belgin Devranoglu ◽  
Ilhan Sanverdi ◽  
...  
Keyword(s):  
Polycystic Ovarian Syndrome ◽  
Total Testosterone ◽  
Short Term ◽  
Ovarian Cortex ◽  
Hormone Profile ◽  
Before And After ◽  
Profile Changes ◽  
Study Designs ◽  
Ovarian Syndrome ◽  
Ovarian Diathermy

<p><strong>Objective:</strong> Some hormonal alterations after ovarian diathermy have been proposed in previous studies. Based on this data, we aimed to analyze some hormone profile changes following oocyte pick-up in women with polycystic ovarian syndrome.<br /><strong></strong></p><p><strong>Study Designs:</strong> A total of 50 women with polycystic ovarian syndrome underwent ovarian stimulation for IVF cycle with an indication of anovulatory infertility. Some hormone profiles with the insulin resistance were assessed before and after oocyte pick-up to (early in the morning before starting stimulation and repeated 1 month later from oocyte pick-up day) assess whether high number of needle entries into the ovarian cortex and stroma result in similar effect with the diathermy.<br /><strong></strong></p><p><strong>Results:</strong> Comparison of some variables revealed significantly decreased HOMA-IR and serum total testosterone concentrations after intervention. Correlation analyses showed significant correlations between number of needle entries, change in HOMA-IR, baseline total testosterone level and change in AMH level. <br /><strong></strong></p><p><strong>Conclusion:</strong> Our data showed significant metabolic and hormonal alterations following oocyte pick up consistent with the effect of ovarian diathermy in women with polycystic ovarian syndrome.</p>

scholarly journals Influence of ovarian manipulation on reproductive endocrinology in polycystic ovarian syndrome and regularly cycling women

2013 ◽  
Vol 169 (4) ◽  
pp. 503-510 ◽  
Author(s):  
M L Hendriks ◽  
T König ◽  
R S Soleman ◽  
T Korsen ◽  
R Schats ◽  
...  
Keyword(s):  
Polycystic Ovarian Syndrome ◽  
Transvaginal Ultrasound ◽  
Ovarian Hormones ◽  
Pulse Interval ◽  
Hormonal Changes ◽  
Before And After ◽  
Mechanical Manipulation ◽  
Lh Secretion ◽  
Late Follicular Phase ◽  
Ovarian Syndrome

ObjectiveLittle is known about the function of the ovarian neuronal network in humans. In many species, copulation influences endocrinology through this network. As a first step, the possible influence of ovarian mechanical manipulation on pituitary and ovarian hormones was evaluated in polycystic ovarian syndrome (PCOS) and regularly cycling women. DesignProspective case–control study (2008–2010).MethodsTen PCOS women (Rotterdam criteria) undergoing ovulation induction with recombinant-FSH and ten normal ovulatory controls were included in an academic fertility clinic. In the late follicular phase blood was drawn every 10 min for 6 h. After 3 h the ovaries were mechanically manipulated by moving a transvaginal ultrasound probe firmly over each ovary ten times. Main outcome measures were LH and FSH pulsatility and ovarian hormones before and after ovarian manipulation.ResultsAll PCOS patients showed an LH decline after the ovarian manipulation (before 13.0 U/l and after 10.4 U/l, P<0.01), probably based on a combination of a longer LH pulse interval and smaller amplitude (P=0.07). The controls showed no LH change (before 9.6 U/l and after 9.3 U/l, P=0.67). None of the ovarian hormones (estradiol, progesterone, anti-Müllerian hormone, inhibin B, androstenedione and testosterone) changed in either group.ConclusionsOvarian mechanical manipulation lowers LH secretion immediately and typically only in preovulatory PCOS patients. The immediate LH change after the ovarian manipulation without any accompanying ovarian hormonal changes point to nonhormonal communication from the ovaries to the pituitary. A neuronal pathway from the ovaries communicating to the hypothalamic–pituitary system is the most reasonable explanation.

scholarly journals SUN-004 Case Study: A 17-year-old Girl with HAIR-AN Syndrome, T2DM and Primary Amenorrhea

2020 ◽  
Vol 4 (Supplement_1) ◽  
Author(s):  
Abdulghani Habib Alsaeed ◽  
Hayat Al Harthi
Keyword(s):  
Insulin Resistance ◽  
Adolescent Girl ◽  
Acanthosis Nigricans ◽  
Polycystic Ovarian Syndrome ◽  
Ethinyl Estradiol ◽  
Free Testosterone ◽  
Primary Amenorrhea ◽  
Total Testosterone ◽  
Thyroid Function Tests ◽  
Ovarian Syndrome

Abstract Introduction: HAIR-AN syndrome is a sub-type of polycystic ovarian syndrome which consists of virilization, insulin resistance and acanthosis nigricans. It may be associated with menstrual irregularity, and hyperandrogenic features such as hirsutism and masculinization. Aim: We report an adolescent girl with HAIR-AN syndrome, T2DM, a very high testosterone level (male range) and primary amenorrhea Case report: A 17-year-old female who had been investigated by pediatric endocrinology since the age of 13 because of hyperpigmentation which was proven to be acanthosis nigricans on skin biopsy. The patient was found to have insulin resistance with initially normal glucose level. She has hirsutism and hypertrichosis. There is no similar condition in her family, she has three siblings all are well. She developed T2DM with at the age of 14. She was started on Metformin 2 gram daily and them pioglitazone 30 mg was added when she was 16 years. She never had menarche. The clinical examination revealed an adolescent girl with normal BP 106/68 mmHg, and BMI 19.6kg/m2. She scored 24 onFerriman-Gallwey hirsutism scoring system. She had severe acanthosis nigricans on both axillae. She also had back and upper limbs hyperpigmentation.Lab tests revealed normal thyroid function tests, prolactin, cortisol, DHEA-S, and 17 hydroxy progesterone. Fasting glucose 7.2, insulin 123 μU/ml (2.6-24.9), c-peptide 964, HbA1c 8.2%. Total testosterone 24.61 nmol/L (0.069-2.715), SHBG 184.9 nmol/L, and Free testosterone index 13.31 (0.51-6.53). Her LH 8.9 and FSH 4.7.Radiological investigations revealed polycystic ovaries on pelvic ultrasound. MRI abdomen showed normal adrenals, and mildly enlarged ovaries with peripherally located follicles consistent with polycystic ovarian syndrome. The patient was started in Diane-35 (cyproterone acetate and ethinyl estradiol) oral pills. She started to have menarche three months after using Diane-35. Her Total testosterone had dropped from 24.61 to 1.69 nmol/L (0.069-2.715), SHBG 579 nmol/L, and Free testosterone index 0.29 (0.51-6.53). She reported that the hirsutism is getting less than before starting the treatment.Conclusion: Primary amenorrhea might be a manifestation of in HAIR-AN syndrome due to sever hyperandrogenism. The management of such condition is challenging. In addition to controlling the metabolic parameters, combined oral pills with antiandrogen effect might be effective.

scholarly journals The effect of progressive muscle relaxation on depression in polycystic ovarian syndrome

2018 ◽  
Vol 7 (8) ◽  
pp. 3029
Author(s):  
Jyoti Parle ◽  
Aishwarya D. Savant
Keyword(s):  
Polycystic Ovarian Syndrome ◽  
Polycystic Ovary ◽  
Muscle Relaxation ◽  
Progressive Muscle Relaxation ◽  
Reproductive Age ◽  
Ovary Syndrome ◽  
Exclusion Criteria ◽  
Before And After ◽  
Muscle Groups ◽  
Ovarian Syndrome

Background: Polycystic ovary syndrome (PCOS) is the most common endocrine disorder among women of reproductive age. Authors explored the effects of progressive muscle relaxation (PMR) on depression in females with polycystic ovarian syndrome (PCOS).Methods: In a 4-week study duration in which the intervention was for three times a week, 30 females which were selected according to the inclusion and exclusion criteria received a PMR protocol in which subjects were taught to contract and relax 16 muscle groups. The Becks Depression Inventory (BDI) was taken before and after the intervention as a depression analysis tool.Results: After 4 weeks of intervention, the patients showed significant improvement in depression (P < 0.05).Conclusions: In conclusion, this study suggests that PMR practice is effective in improving depression, in patients with PCOS.

scholarly journals Study of Serum Chemerin in Patients of Polycystic Ovarian Syndrome and its Relation to Insulin Resistance

QJM ◽  
2020 ◽  
Vol 113 (Supplement_1) ◽  
Author(s):  
M R Halawa ◽  
R S Abdelbaky ◽  
Y M Eid ◽  
M S Nasr ◽  
L M Hendawy ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Blood Glucose ◽  
Polycystic Ovarian Syndrome ◽  
Fasting Blood Glucose ◽  
Control Group ◽  
Total Testosterone ◽  
Model Assessment ◽  
Fasting Insulin ◽  
Obese Women ◽  
Ovarian Syndrome

Abstract Background study of chemerin level in polycystic ovarian syndrome (PCO) patients and its relation to insulin resistance (IR). Upon chemerin on adipose tissue and glucose metabolism, serum chemerin has been recently studied in (PCO) women Aim We aimed to study the level of serum chemerin in PCO patients and its relation to insulin resistance. Methods The current study included 45 subjects with PCO syndrome and 45 healthy subjects as a control group. PCO subjects were divided into 27 obese PCO and 18 lean PCO. Control women were divided into 25 obese women and 20 lean women. Measurement of serum chemerin levels, fasting blood glucose (FBG),fasting insulin (FIN), total testosterone and pelvic ultrasonography Results Serum chemerin was significantly higher in the obese PCOS group (99.65 ± 13.72 ng/mL) compared with lean PCOS (87.99 ± 5,64 ng/mL) and the obese (76.82 ± 2.39 ng/mL) and non-obese (69.19 ± 8.40 ng/mL) control groups. In PCOS women, serum chemerin levels were positively correlated with Body mass index (BMI) (r = 0.835, P &lt; 0.001), Fasting blood glucose (FBG) (r = 0.493, P &lt; 0.005), Fasting insulin (FIN) (r = 0.913, P &lt; 0.001), Homeostasis model assessment of insulin resistance (HOMA-IR) (r = 0.9181, P &lt; 0.001). Conclusion There is an increase in serum chemerin level in PCOS patients with even more significant increase in patients with obese PCOS.

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