scholarly journals Effect of (Alpinia officinarum) Hance on Sex Hormones and Certain Biochemical Parameters of Adult Male Experimental Rats

2019 ◽  
Vol 10 (9) ◽  
pp. 315-322
Author(s):  
Shaimaa Negm ◽  
Eman Ragheb
Keyword(s):  
Sex Hormones ◽  
Adult Male ◽  
Biochemical Parameters ◽  
Alpinia Officinarum

Effects of BDE-99 on hormone homeostasis and biochemical parameters in adult male rats

2010 ◽  
Vol 48 (8-9) ◽  
pp. 2206-2211 ◽  
Author(s):  
Virginia Alonso ◽  
Victoria Linares ◽  
Montserrat Bellés ◽  
María Luisa Albina ◽  
Andreu Pujol ◽  
...  
Keyword(s):  
Adult Male ◽  
Biochemical Parameters ◽  
Male Rats ◽  
Hormone Homeostasis

scholarly journals Male-specific suppression of hepatic microsomal UDP-glucuronosyl transferase activities toward sex hormones in the adult male rat administered bisphenol A

2002 ◽  
Vol 368 (3) ◽  
pp. 783-788 ◽  
Author(s):  
Noriaki SHIBATA ◽  
Junya MATSUMOTO ◽  
Ken NAKADA ◽  
Akira YUASA ◽  
Hiroshi YOKOTA
Keyword(s):  
Bisphenol A ◽  
Mrna Expression ◽  
Sex Hormones ◽  
Adult Male ◽  
Endocrine Disruptor ◽  
Liver Microsomes ◽  
Female Rats ◽  
Male Rats ◽  
Male Rat ◽  
Blotting Analysis

Various adverse effects of endocrine disruptors on the reproductive organs of male animals have been reported. We found that UDP-glucuronosyltransferase (UGT) activities towards bisphenol A, testosterone and oestradiol were significantly decreased in liver microsomes prepared from adult male Wistar rats administered with the endocrine disruptor bisphenol A (1mg/2 days for 2 or 4 weeks). However, suppression of the transferase activities was not observed in female rats, even after bisphenol A treatment for 4 weeks. Diethylstilbestrol, which is well known as an endocrine disruptor, had the same effects, but p-cumylphenol had no effect on UGT activities towards sex hormones. Co-administration of an anti-oestrogen, tamoxifen, inhibited the suppression of the transferase activities by bisphenol A. Western blotting analysis showed that the amount of UGT2B1, an isoform of UGT which glucuronidates bisphenol A, was decreased in the rat liver microsomes by the treatment. Northern blotting analysis also indicated that UGT2B1 mRNA in the liver was decreased by bisphenol A treatment. The suppression of UGT activities, UGT2B1 protein and UGT2B1 mRNA expression did not occur in female rats. The results indicate that bisphenol A treatment reduces the mRNA expression of UGT2B1 and other UGT isoforms that mediate the glucuronidation of sex hormones in adult male rats, and this suggests that the endocrine balance may be disrupted by suppression of glucuronidation.

The Effect of Different Doses of Green Tea Extract on Hematological and Biochemical Parameters in Adult Male Rats

2020 ◽  
Vol 11 (2) ◽  
pp. 1418
Author(s):  
Omer Mahrouf Ali Shoshin ◽  
Ahmed Abdulaali Azeez Baker ◽  
Evan Mohammed Mostafa ◽  
Noor Abdulaali Azeez Baker ◽  
Ahmad Salih Helal
Keyword(s):  
Green Tea ◽  
Adult Male ◽  
Biochemical Parameters ◽  
Green Tea Extract ◽  
Male Rats ◽  
Hematological And Biochemical Parameters ◽  
Tea Extract ◽  
Different Doses

scholarly journals Influence of Fetoplacentary Insufficiency of Mothers on the State of Spermatogenesis of Male Offspring

2020 ◽  
Vol 5 (5) ◽  
pp. 343-348
Author(s):  
N. Yu. Seliukova ◽  
◽  
K. V. Misyura ◽  
D. V. Morozenko ◽  
R. V. Dotsenko ◽  
...  
Keyword(s):  
Sex Hormones ◽  
Adult Male ◽  
Reproductive System ◽  
The State ◽  
Male Offspring ◽  
Reproductive Age ◽  
Toxic Substances ◽  
Long Term Effects ◽  
Testosterone Levels

The demographic situation in most countries of the European region, which includes Ukraine, is characterized as quite complex. Nowadays the question of the long-term effects of maternal fetoplacental insufficiency on the functioning of human body systems, in particular on the reproductive system of male offspring, remains open. It is known that negative factors during pregnancy can affect the development and existence of the individual. The purpose of the work was to study the long-term effects of fetoplacental insufficiency on the functioning of the reproductive system of adult male offspring born by mothers of different ages. Material and methods. The study was performed on healthy adult female Wistar rats, young (3 months) and mature (10 months) of reproductive age. 4 groups were formed: the 1st and the 2nd groups included intact animals of young and mature age; the 3rd and the 4th had females with experimental fetoplacental insufficiency of young and mature reproductive age. Modeling of fetoplacental insufficiency was performed by daily subcutaneous injection to females from the 12th to the 18th day of pregnancy 50% oil solution of carbon tetrachloride at a dose of 2 ml/kg body weight. We studied the state of spermatogenesis, weight of internal organs, sex hormones in mature male offspring of 3 months of age after decapitation. Results and discussion. Fetoplacental insufficiency leads to lower testosterone levels in all offspring born to mothers of different reproductive ages. The total level of estradiol remained almost unchanged, but still, in animals there was a shift in the ratio of sex hormones in the direction of hyperestrogenism. Experimental fetoplacental insufficiency in females of different reproductive ages also affected the mass of the testes, epididymis and adrenal glands in their male offspring. According to the indicators of the functional state of epididymal sperm in animals born by reproductively young females, the share of pathological forms of sperm decreased by 45%, in the offspring born by reproductively mature females with fetoplacental insufficiency decreased the number of motile sperm by 46% compared to the intact group of animals. Conclusion. The penetration of toxic substances into the mother's body leads to varying degrees of total xenobiotic load, followed by induction of neutralization reactions and the development of metabolic forms of fetoplacental insufficiency, changing the function of the endocrine system and causing adverse effects on the reproductive system. Fetoplacental insufficiency affects the reproductive function of adult male offspring born to mothers of different reproductive ages, which is manifested in a decrease in testosterone levels and deterioration of the spermogram, which in turn can lead to problems with impregnation

Inductive influence of testosterone upon central sexual maturation in the rat

Development ◽  
1967 ◽  
Vol 17 (1) ◽  
pp. 171-175
Author(s):  
W. N. Adams Smith ◽  
M. T. Peng
Keyword(s):  
Corpus Luteum ◽  
Sex Hormones ◽  
Adult Male ◽  
Sexual Maturation ◽  
Male Genitalia ◽  
Testosterone Propionate ◽  
Single Injection ◽  
Male Rats ◽  
Corpora Lutea

The influence of the testis and of testosterone upon the development of the male genitalia has been extensively investigated and a number of reviews of this work have been published (Jost, 1960; Burns, 1961). However, Witschi (1957) has stressed the need to distinguish between adult sex hormones, such as testosterone, and the secretions of the immature gonad. The formation of corpora lutea in the ovaries transplanted to adult male rats which had been castrated at birth, and the absence of corpus luteum formation in ovaries transplanted to male hosts bearing transplanted testes in the neck from birth, was reported by Pfeiffer in 1936. Similar observations have been reported by Yazaki (1960) and Harris (1964). A single injection of testosterone propionate has been found to lead to permanent sterility and a loss of corpus luteum formation in the ovaries of mice (Barraclough & Leathern, 1954) and rats (Barraclough, 1961).

Effect of Alpinia Officinarum Rhizome Extract on Fertility and Sexual Behavior of Adult Male Albino Rats Treated with Sotalol

2021 ◽  
Vol 84 (1) ◽  
pp. 2285-2296
Author(s):  
Nourhan Mahmoud Abd El-Zaher Bebars ◽  
Mostafa M. El Habeby ◽  
Noha M. Issa ◽  
Nermeen M. Noor El-Dien
Keyword(s):  
Sexual Behavior ◽  
Adult Male ◽  
Albino Rats ◽  
Alpinia Officinarum
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