PROTECTIVE EFFECTS OF Β-CAROTENE ON GAMMA RADIATION-INDUCED RENALHISTOLOGICAL AND ULTRASTRUCTURAL CHANGES IN ALBINO RATS

2008 ◽  
Vol 4 (6) ◽  
pp. 552-566
Author(s):  
Seham, Abo Nour ◽  
Mohamed Rady ◽  
Ihab, Khalil
Keyword(s):  
Gamma Radiation ◽  
Ultrastructural Changes ◽  
Albino Rats ◽  
Protective Effects ◽  
Radiation Induced ◽  
Β Carotene

The role of Echinacea extract to protect the damage effects of gammaradiation on some biochemical constituents in male albino rats

2016 ◽  
Author(s):  
A. G. Ahmed ◽  
Nahed Abdelaziz ◽  
H. M. El-Shennawy ◽  
A. N. El Shahat ◽  
R. G. Hamza
Keyword(s):  
Tissue Damage ◽  
Male Rats ◽  
Albino Rats ◽  
Protective Effects ◽  
Severe Damage ◽  
Biochemical Alterations ◽  
Radiation Induced ◽  
Effects Of Radiation ◽  
Echinacea Extract

The present study was designed to determine the possible protective effects of E. purpurea extracts (EPE) against gamma (g-) radiation exposure (6Gy) induced biochemical alterations and oxidative tissue damage (liver and testes) in male rats given EPE (100 mg/kg/day for 8 weeks) prior to g-irradiation. It has been found that g-irradiation led to hepatic and testicular oxidative stress with concomitant increase in liver function enzymes. Serum lipid profile and hormone level has also been found altered. Rats dosed with EPE before exposure to g-rays showed significantly less severe damage and remarkable improvement in all of the measured parameters when compared to irradiated rats. It could be concluded that EPE attenuates the deleterious effects of radiation-induced biochemical disorders and tissue damage (liver and testes).

scholarly journals Synergistic Effect of β-Carotene and Metformin on Antihyperglycemic and Antidyslipidemic Activities in Streptozotocin-Induced Diabetic Rats

2021 ◽  
pp. 79-87
Author(s):  
Khadiza Khanam ◽  
Sultana Rajia ◽  
Mim Yeasmin ◽  
Munira Morshed ◽  
Rashidul Haque
Keyword(s):  
Combination Therapy ◽  
Low Density Lipoprotein ◽  
Fasting Blood Glucose ◽  
Density Lipoprotein ◽  
Diabetic Control ◽  
Biological Properties ◽  
Albino Rats ◽  
Protective Effects ◽  
Antidiabetic Therapy ◽  
Β Carotene

Purpose: Worldwide prevalence of diabetes mellitus (DM) has become an issue of great concern in current decades. To date, a large number of biological properties have been reported from carotenoids, particularly protective effects against cancer, cardiovascular diseases, and DM, including enhancement of insulin sensitivity.In this study, we aimed to evaluate the efficacy of β-carotene as an additive agent with metformin in ameliorating Type2 (T2)DM. Methods: In this experiment, fasting blood glucose level (BGL), low density lipoprotein (LDL), high density lipoprotein (HDL), total cholesterol (TC) and triglycerides (TG) were measured in serum of Wister albino rats with streptozotocin (STZ)-induced diabetes and after treatment with metformin (850mg/70kg b.w.) and β-carotene (10 mg/70kg b.w.) administered orally once daily for three weeks. Results: Metformin and β-carotene treatments individually resulted in significant (p<0.001) reversal of the diabetes induced increase in BGL, LDL, TC and TG, whereas significantly increased the STZ-induced decrease in HDL, compared to diabetic control. As compared to the monotherapy, the combination therapy with metformin and β-carotene showed a significant (p<0.001) attenuation of BGL and serum level of LDL, TC, and TG and a slight increase (p<0.05) in serum HDL level, as compared to the treatment with β-carotene, but not with metformin. Conclusion: The combination therapy of β-carotene and metformin produced a significant antidiabetic and antihyperlipidemic effect than the monotherapy alone and provides a scientific rationale for their use in antidiabetic therapy as a potential antioxidant.

scholarly journals Protective effects of caffeic acid phenethyl ester on radiation induced lung injury in rats

2008 ◽  
Vol 31 (5) ◽  
pp. 242 ◽  
Author(s):  
Oguz Galip Yildiz ◽  
Serdar Soyuer ◽  
Recep Saraymen ◽  
Celalettin Eroglu
Keyword(s):  
Radiation Therapy ◽  
Lung Injury ◽  
Caffeic Acid ◽  
Radiation Treatment ◽  
Caffeic Acid Phenethyl Ester ◽  
Albino Rats ◽  
Protective Effects ◽  
Sod Activity ◽  
Radiation Induced

Purpose: The prevention of radiation-induced pulmonary toxicity may help to improve radiation therapy in the cancer patient. The aim of this study was to investigate the pulmonary protective effects of caffeic acid phenethyl ester (CAPE), an antioxidant, on radiation-induced lung injury in rats. Methods:30 Wistar albino rats were divided into three groups and treated with saline, Radiation (RT) and RT + CAPE respectively. All rats were treated with CAPE (50 ?mol/kg i.p.) or saline. The first dose of CAPE was injected 24 h before radiation and application continued daily, with radiation in second day and 2 days more after the radiation treatment. Radiation dose was 800 cGy for total body. At 72 hr after the last radiation application, under general anesthesia using ip ketamine, the lungs were removed immediately after decapitation. After sacrification, antioxidant enzymes catalase (CAT), superoxide dismutase (SOD) activities and malondiadehyde (MDA) levels were evaluated in lung tissue. Results: The level of malondialdehyde (MDA) was higher in the RT group (233.4±1.5 nmol/g protein) than in both the control (131.8±0.92) and the RT + CAPE (151.4±1.8) groups (P < 0.001). However, CAT activity was decreased in the RT group (7.26±0.27 Umg protein) compared with control (8.49±0.51) and increased again in the RT + CAPE group (8.31±0.56; P < 0.001). In accord with CAT activity, SOD activity in the RT group (0.42±0.07 nmolMDA/g wet tissue) was different from the control (0.78±0.02) and RT + CAPE (0.86±0.06) groups (P < 0.001). Conclusion: CAPE aplication with radiation therapy attenuated radiation induced pulmonary injury in vivo, possibly by its antioxidant effect.

scholarly journals Aminoguanidine ameliorates radiation-induced oxidative lung damage in rats

2008 ◽  
Vol 31 (4) ◽  
pp. 182 ◽  
Author(s):  
Celalettin Eroglu ◽  
Oguz Galip Yildiz ◽  
Recep Saraymen ◽  
Serdar Soyuer ◽  
Eser Kilic ◽  
...  
Keyword(s):  
Lung Tissue ◽  
Lung Damage ◽  
Whole Body ◽  
Albino Rats ◽  
Protective Effects ◽  
Biological Damage ◽  
Radiation Induced ◽  
Wistar Albino Rats ◽  
Tissue Lipid Peroxidation ◽  
Endogenous Antioxidant

Purpose: To investigate the possible protective effects of aminoguanidine (AG ) on lung damage in whole body irradiated rats. Methods: To evaluate the biological damage of radiation on rat lung tissue, lipid peroxidation products were measured using biochemical parameters. Thirty Wistar albino rats were divided into three subgroups: control (C) , irradiation alone (RT), and RT + AG combined. After sacrificing the rats, antioxidant enzymes catalase (CAT), superoxide dismutase (SOD) and glutathione peroxidase (GSHPx) activities and malondiadehyde (MDA), nitric oxide (NO) levels were evaluated in lung tissue. Results: Administration of AG resulted in an increase in the activities of CAT, SOD and GSHPx in the lungs. All were reduced after radiatio. In addition, AG administration resulted in a decrease in both NO and MDA levels in lung compared with the irradiated group. Conclusion: Amnoguanidine increased the endogenous antioxidant defence mechanism in rats and protected the animals from radiation-induced lung toxicity. Moreover, AG may protect against ionizing radiation-induced lung damage because of its antioxidant effect.

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