PROTECTIVE EFFECT OF Β-CAROTENE ON GAMMA RADIATION- INDUCED RENAL HISTOLOGICAL AND ULTRASTRUCTURAL CHANGES IN MALE ALBINO RATS

2008 ◽  
Vol 19 (Issue 1-C) ◽  
pp. 27-44
Author(s):  
SEHAM ABU-NOUR ◽  
MOHAMED RADY ◽  
IHAB KHALIL
Keyword(s):  
Gamma Radiation ◽  
Protective Effect ◽  
Ultrastructural Changes ◽  
Albino Rats ◽  
Radiation Induced ◽  
Β Carotene

Protective effect of essential oil from Citrus limon against aspirin-induced toxicity in rats

2018 ◽  
Vol 38 (5) ◽  
pp. 499-509 ◽  
Author(s):  
H Bouzenna ◽  
N Samout ◽  
S Dhibi ◽  
S Mbarki ◽  
S Akermi ◽  
...  
Keyword(s):  
Essential Oil ◽  
Protective Effect ◽  
Antioxidant Activities ◽  
Reducing Power ◽  
Female Rats ◽  
Control Group ◽  
Albino Rats ◽  
Citrus Limon ◽  
Β Carotene ◽  
Aspirin Group

The present study is planned to examine the antioxidant activity (AA) and the protective effect of the essential oil of Citrus limon (EOC) against aspirin-induced histopathological changes in the brain, lung, and intestine of female rats. For this purpose, 28 albino rats were classified to control group (group C), aspirin group (group A), EOC group (group EOC), and pretreatment with EOC and treated with aspirin group (group EOC + A). The antioxidant activities of EOC were evaluated by three different assays including reducing power, β-carotene, and scavenging of hydrogen peroxide (H2O2). Our results found that EOC represents, respectively (0.064 ± 0.013 and 0.027 ± 00 mg Quer E/100 µL), of flavonoid and flavonol. Then, it exhibited a potential activity of reducing power (at 300 mg/mL, which was found to be 0.82 ± 0.07), β-carotene-linoleic acid (AA% = 69.28 ± 3.5%), and scavenging of H2O2 (IC50 = 0.23 ± 0.008 mg/mL). In vivo, aspirin given to rats at the dose of 600 mg/kg body weight induced histomorphological damage in brain, lung, and intestine. However, our data found that the pretreatment with EOC offered a significant protection against the injury induced by aspirin. It can be concluded that the protective effect of EOC can be due to its antioxidant activities.

scholarly journals Protective effect of phloroglucinol against gamma radiation-induced oxidative stress in hair follicles

2016 ◽  
Vol 56 (1) ◽  
pp. 29-35
Author(s):  
Areum Kim ◽  
So Jin Bing ◽  
Jinhee Cho ◽  
KHINM Herath ◽  
You-Jin Jeon ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Gamma Radiation ◽  
Protective Effect ◽  
Hair Follicles ◽  
Radiation Induced

Protective effects of erdosteine against nephrotoxicity caused by gamma radiation in male albino rats

2015 ◽  
Vol 35 (1) ◽  
pp. 21-28 ◽  
Author(s):  
AA Elkady ◽  
IM Ibrahim
Keyword(s):  
Body Weight ◽  
Gamma Radiation ◽  
Gamma Irradiation ◽  
Gastric Tube ◽  
Whole Body ◽  
Control Group ◽  
Albino Rats ◽  
Once Daily ◽  
Renal Lesions ◽  
Radiation Induced

The aim of this study was focused on investigating the possible protective effect of erdosteine against gamma radiation-induced renal lesions in male albino rats. Twenty-eight albino rats were divided into four equal groups as follows: control group, irradiated group (animals subjected to whole-body gamma irradiation at a dose of 5 Gy), treated group (each rat received 100 mg/kg body weight once daily, orally by gastric tube, erdosteine for 1 week), and treated irradiated group (each rat received 100 mg/kg body weight once daily, orally by gastric tube, erdosteine for 1 week, then exposed to whole-body gamma irradiation at a dose of 5 Gy). The results revealed that the administration of erdosteine to rats before irradiation significantly ameliorated the changes occurred in kidney function (creatinine and urea) compared with irradiated group. Also the changes in serum tumor necrosis factor α, interleukin 1β, and interleukin 6 activities were markedly improved compared with the corresponding values of irradiated group. Kidney catalase and glutathione peroxidase (GPx) activities and reduced glutathione concentration showed approximately normal level when compared with the irradiated group. The histopathological results showed distinctive pattern of renal lesions in irradiated group, while in treated irradiated group the renal tissues showed relatively well-preserved architecture. Erdosteine acts in the kidney as a potent scavenger of free radicals to prevent or ameliorate the toxic effects of gamma irradiation as shown in the biochemical and histopathological changes and might provide substantial protection against radiation-induced inflammatory damage.

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