scholarly journals Effects of dietary chitosan nanoparticles on serum lipid concentration in hyperlipidemic rats induced by high-fat diet

2016 ◽  
Vol 54 (4) ◽  
pp. 17-21
Keyword(s):  
High Fat Diet ◽  
Serum Lipid ◽  
Chitosan Nanoparticles ◽  
Lipid Concentration ◽  
High Fat ◽  
Serum Lipid Concentration

scholarly journals PO-111 Effects of aerobic exercise on fatty acid metabolism in liver of NAFLD Rats

2018 ◽  
Vol 1 (4) ◽  
Author(s):  
Wen Jing ◽  
Chuanfen Li ◽  
Jingguo Zhao
Keyword(s):  
Fatty Acid ◽  
Liver Function ◽  
Aerobic Exercise ◽  
High Fat Diet ◽  
Acid Metabolism ◽  
Serum Levels ◽  
Lipid Concentration ◽  
High Fat ◽  
Expression Levels ◽  
Serum Lipid Concentration

 Objective Aerobic exercise can improve liver metabolic diseases such as non-alcoholic fatty liverdisease (NAFLD), but the molecular mechanism is not completely clear, which limits the applicationof aerobic exercise in the treatment and improvement of NAFLD. In this paper, the effects of aerobicexercise on the expression levels of important genes regulating fatty acid metabolism in the liver ofNAFLD rats were studied in order to explore the possible molecular mechanism of aerobic exerciseregulating hepatic fatty acid metabolism.Methods 1. Animal grouping. 36 male Sprague Dawley (SD) rats aged 21 days old were randomlydivided into three groups after 1 week of adaptive feeding: 10 in the normal diet quiet group (NCgroup), 10 in the high-fat diet quiet group (HC group) and 16 in the high-fat diet exercise group (HTgroup). 2. Training arrangements. After 12 weeks, the rats in the HT group underwent 8 weeks ofaerobic exercise with a training intensity of 25m/min, and continued exercise for 1h/d, 6d/w for atotal of 8 weeks. 3. Sample collection. After an overnight fast, rats in the three groups were weighedand anesthetized with an intraperitoneal injection of 10% chloral hydrate (0.3 ml/100 g bodyweight). Blood samples were collected from the aortaventralis, centrifuged, and kept frozen at -80 °Cfor chemical assays. The rat liver was removed, frozen in liquid nitrogen, and stored in a -80 °Cfreezer. 4. Serum lipid concentration and liver function detection. Serum levels of total cholesterol(TC), triglyceride (TG), high density lipoprotein cholesterol (HDL-C), low density lipoproteincholesterol (LDL-C), free fatty acid (FFA), aspartate aminotransferase (AST) and alanineaminotransferase (ALT) were detected in three groups of rats. 5. Detection of expression levels offatty acid metabolism related genes in liver. The expression levels of AMP-activated protein kinase(AMPK), silence information regulator 1 (SIRT1), peroxisome proliferator-activated receptor γcoactivator 1α (PGC-1α) in rat liver were detected by SYBR Green real-time PCR. 6. Data statistics.Results were expressed in the form of mean±standard deviation. Spss17.0 statistical software wasused to conduct one-way ANOVA to compare the differences between the groups, p<0.05 indicatessignificant difference between groups.Results 1. Effects of aerobic exercise on Blood lipids and liver function. The serum levels of TC, TG,LDL-C, FFA, AST and ALT in HC group were significantly higher than those in NC group (p < 0.05),while HDL-C level was significantly lower (p < 0.05). The serum concentrations of TC, TG, LDL-C, FFA,AST and ALT in HT group were significantly lower than those in HC group (p < 0.05), while HDL-Clevel was significantly higher (p < 0.05). 2.Effects of aerobic exercise on the expression of fatty acidmetabolism regulatory genes in liver of rats. The mRNA expression levels of AMPK, SIRT1 and PGC-1α in liver of HC group were significantly lower than those of NC group (p < 0. 05). While the mRNAexpression levels of AMPK, SIRT1 and PGC-1 α in liver of HT group were significantly higher thanthose of HC group (p < 0. 05).Conclusions Aerobic exercise can improve serum lipid concentration and liver function in NAFLDrats. It increased the consumption of ATP, led to an increase in AMP/ATP ratio, enhanced the mRNAexpression of AMPK, SIRT1 and PGC-1α, activated AMPK - SIRT1 - PGC-1α signaling pathway,reduced hepatic fat synthesis and accelerated fatty acid oxidation in NAFLD rats liver.  

scholarly journals SERUM LIPID PROFILE;

2008 ◽  
Vol 15 (04) ◽  
pp. 500-507
Author(s):  
MUHAMMAD ANWAR BURIRO ◽  
MUHAMMAD TAYYAB
Keyword(s):  
Sunflower Oil ◽  
High Fat Diet ◽  
Serum Lipid ◽  
Nigella Sativa ◽  
Albino Rats ◽  
High Fat ◽  
Low Fat ◽  
Control Groups ◽  
Low Fat Diet ◽  
Lipid Fractions

Objective: To determine the effects of Nigella sativa and sunflower oil diet intake on serum lipid profile in albino rats. Material& Methods: Eighty four albino rats with equal number of males and females were selected for the study, they were divided into six differentgroups, Control groups1,111,V,were given low fat diet(3%),high fat diet(20%), high fat diet supplemented with bile salt (1% colic acid) andantithyroid drug (0.5% propylthiouracil). The Experimental groups were given the above diets with supplemented Nigella sativa. Low fat dietincreased all the lipid fractions significantly when given at12 and 24 weeks duration as compared to 0 week. Results: The high fat diet whengiven at different intervals decreased all lipid fractions significantly as compared to baseline level. The high fat diet with propylthiouracil andbile salt also increased all the lipid fractions and the increase was more as compared to previous groups. The supplements of Nigella sativain the groups decreased all the lipid fractions significantly as compared to the control groups except HDL-c, which was significantly increasedin all the experimental groups as compared to control groups. Conclusion: On the basis of these findings conclusions are made, that Nigellasativa has got TG,TC, and LDL-c lowering and HDL-c raising effects.3% sunflower oil low fat diet has got TG,TC,HDL-c, and LDL-c raisingeffects.20% sunflower oil high fat diet has got TG,TC,HDL-c and LDL-c lowering effects. Both Nigella sativa and sunflower oil have got lowatherogenic index (TC/HDL) and may be recommended in hyperlipidaemic patients or normal individuals.

Soyasaponins Reduce Inflammation and Improve Serum Lipid Profiles and Glucose Homeostasis in High Fat Diet-Induced Obese Mice

2018 ◽  
Vol 62 (19) ◽  
pp. 1800205 ◽  
Author(s):  
Qunying Xie ◽  
Xiangfu Gu ◽  
Junbin Chen ◽  
Minshun Liu ◽  
Fei Xiong ◽  
...  
Keyword(s):  
Glucose Homeostasis ◽  
High Fat Diet ◽  
Serum Lipid ◽  
Lipid Profiles ◽  
Obese Mice ◽  
High Fat

Soyasaponins A1 and A2 exert anti-atherosclerotic functionalities by decreasing hypercholesterolemia and inflammation in high fat diet (HFD)-fed ApoE−/− mice

2020 ◽  
Vol 11 (1) ◽  
pp. 253-269 ◽  
Author(s):  
Qunying Xie ◽  
Fei Xiong ◽  
Xinglong Wu ◽  
Junbin Chen ◽  
Xiangfu Gu ◽  
...  
Keyword(s):  
Lipid Profile ◽  
High Fat Diet ◽  
Serum Lipid ◽  
Serum Lipid Profile ◽  
High Fat

To the best of our knowledge, this study firstly shows that soyasaponins (A1 & A2) exhibit antiatherosclerotic bioactivities by improving the serum lipid profile and reducing TLR4-/MyD88-/NF-κB-mediated inflammations in high fat diet-fed ApoE−/− mice.

Sign in / Sign up

Export Citation Format

Share Document