scholarly journals Bone marrow derived mesenchymal stem cells suppress diethylnitrosamine induced liver cirrhosis in rats

2019 ◽  
Vol 14 (1) ◽  
pp. 75-84
Author(s):  
Yousry E.AboEl-Magd ◽  
Mohamed G.Mohamed ◽  
Nermin Raafa ◽  
Hagar A.El-Turky
Keyword(s):  
Stem Cells ◽  
Bone Marrow ◽  
Mesenchymal Stem Cells ◽  
Liver Cirrhosis

Molecular and Cellular Functions Distinguish Superior Therapeutic Efficiency of Bone Marrow CD45 Cells Over Mesenchymal Stem Cells in Liver Cirrhosis

Stem Cells ◽  
2015 ◽  
Vol 34 (1) ◽  
pp. 135-147 ◽  
Author(s):  
Prakash Baligar ◽  
Snehasish Mukherjee ◽  
Veena Kochat ◽  
Archana Rastogi ◽  
Asok Mukhopadhyay
Keyword(s):  
Stem Cells ◽  
Bone Marrow ◽  
Mesenchymal Stem Cells ◽  
Liver Cirrhosis ◽  
Cellular Functions ◽  
Therapeutic Efficiency

Resveratrol pretreatment enhanced homing of SDF-1α-preconditioned bone marrow-derived mesenchymal stem cells in a rat model of liver cirrhosis

2017 ◽  
Vol 119 (3) ◽  
pp. 2939-2950 ◽  
Author(s):  
Mehrdad Hajinejad ◽  
Parichehr Pasbakhsh ◽  
Ameneh Omidi ◽  
Keywan Mortezaee ◽  
Saied Nekoonam ◽  
...  
Keyword(s):  
Stem Cells ◽  
Bone Marrow ◽  
Mesenchymal Stem Cells ◽  
Liver Cirrhosis ◽  
Rat Model

scholarly journals Functional properties of mesenchymal multipotent stromal stem cells obtained from bone marrow of patients with liver cirrhosis

2014 ◽  
Vol 95 (5) ◽  
pp. 669-674
Author(s):  
B A Agaev ◽  
R M Agaev ◽  
A G Popandopulo ◽  
R E Dzhafarli
Keyword(s):  
Stem Cells ◽  
Bone Marrow ◽  
Mesenchymal Stem Cells ◽  
Liver Cirrhosis ◽  
Functional Properties ◽  
Primary Cultures ◽  
Small Cells ◽  
Viral Etiology ◽  
Phenotypic Properties ◽  
Autologous Mesenchymal Stem Cells

Aim. To study of the functional properties of autologous mesenchymal multipotent stem cells in patients with cirrhosis of different etiologies. Methods. Studied were the functional and phenotypic properties of autologous mesenchymal stem cells derived from the bone marrow in 35 patients (26 men and 9 women) with cirrhosis of the liver at the age of 19-53 years. Among the patients studied viral etiology was diagnosed in 18 (51.4%), alcohol - in 13 (37.1%), autoimmune - in 4 (11.4%) patients with liver cirrhosis. Results. Autologous mesenchymal stem cells from all of the observed patients were able to divide. The highest yield and the doubling rate of cell populations were observed in patients with viral cirrhosis. Comparative morphometric study of primary cultures derived stem cells in patients with autoimmune and alcoholic hepatitis, showed the presence of relatively small cells (less than 20 microns), which make up about 30% of the total number of cells. At the same time, in bone marrow derived cell cultures of patients with viral etiology of the disease the number of small cells was 1.5 times greater which makes approximately 49% of the total cell population. The vast majority of cultured stem cells, regardless of the etiology of cirrhosis express specific for these cells «stromal» markers - CD73, CD90 and CD105. Autologous mesenchymal stem cells isolated from bone marrow of patients with alcoholic liver cirrhosis characterized by the most pronounced pro-inflammatory, immunoregulatory potential. Conclusion. Functional and phenotypic properties of autologous mesenchymal stem cells in various forms of cirrhosis are different which requires adequate cultivation and correction before their transplantation.

scholarly journals Progress of Interference of Traditional Chinese Medicine on Cirrhosis Treated with Bone Marrow Mesenchymal Stem Cells

2021 ◽  
Vol 2021 ◽  
pp. 1-7
Author(s):  
Yaxin Wang ◽  
Huicun Zhang ◽  
Hongbing Wang
Keyword(s):  
Stem Cells ◽  
Bone Marrow ◽  
Mesenchymal Stem Cells ◽  
Liver Cirrhosis ◽  
Chinese Medicine ◽  
Traditional Chinese Medicine ◽  
Specific Mechanism ◽  
Improve Liver Function ◽  
Marrow Mesenchymal Stem Cells ◽  
Stem Cells Transplantation

Transplantation of bone marrow mesenchymal stem cells has attracted more and more attention as a regenerative therapy for the treatment of liver diseases. A large number of studies have shown that this kind of cells can inhibit the activation of hepatic stellate cells and regulate tissue homeostasis and immune system via a variety of ways. Meanwhile, bone marrow mesenchymal stem cells can inhibit apoptosis of hepatocyte, improve liver function, and reduce inflammation through multiple pathways. These cells have a broad prospect in the treatment of liver cirrhosis. At present, there are many studies on the specific mechanism of bone marrow mesenchymal stem cells transplantation in the treatment of liver cirrhosis. This paper reviews the pathogenesis of liver cirrhosis and the mechanism of bone marrow mesenchymal stem cells transplantation in the treatment of liver cirrhosis, discusses the effectiveness of traditional Chinese medicine method in enhancing the efficacy of bone marrow mesenchymal stem cells transplantation, and looks forward to its application prospect in the future.

Effect of Genetic Instability on the Quality of Mesenchymal Stem Cells from Bone Marrow of Patients with Liver Cirrhosis

2017 ◽  
Vol 152 (5) ◽  
pp. S1160
Author(s):  
Smitha Mathews ◽  
Arish Naqvi ◽  
Rao Pn ◽  
Mithun Sharma ◽  
Ganesh Jaishetwar ◽  
...  
Keyword(s):  
Stem Cells ◽  
Bone Marrow ◽  
Mesenchymal Stem Cells ◽  
Liver Cirrhosis ◽  
Genetic Instability

scholarly journals Comparison of the Treatment Efficiency of Bone Marrow-Derived Mesenchymal Stem Cell Transplantation via Tail and Portal Veins in CCl4-Induced Mouse Liver Fibrosis

2016 ◽  
Vol 2016 ◽  
pp. 1-13 ◽  
Author(s):  
Nhung Hai Truong ◽  
Nam Hai Nguyen ◽  
Trinh Van Le ◽  
Ngoc Bich Vu ◽  
Nghia Huynh ◽  
...  
Keyword(s):  
Stem Cells ◽  
Bone Marrow ◽  
Mesenchymal Stem Cells ◽  
Liver Cirrhosis ◽  
Liver Fibrosis ◽  
Mouse Liver ◽  
Treatment Effects ◽  
Mouse Bone Marrow ◽  
Mesenchymal Stem Cell Transplantation ◽  
Portal Veins

Because of self-renewal, strong proliferationin vitro, abundant sources for isolation, and a high differentiation capacity, mesenchymal stem cells are suggested to be potentially therapeutic for liver fibrosis/cirrhosis. In this study, we evaluated the treatment effects of mouse bone marrow-derived mesenchymal stem cells (BM-MSCs) on mouse liver cirrhosis induced by carbon tetrachloride. Portal and tail vein transplantations were examined to evaluate the effects of different injection routes on the liver cirrhosis model at 21 days after transplantation. BM-MSCs transplantation reduced aspartate aminotransferase/alanine aminotransferase levels at 21 days after injection. Furthermore, BM-MSCs induced positive changes in serum bilirubin and albumin and downregulated expression of integrins (600- to 7000-fold), transforming growth factor, and procollagen-α1 compared with the control group. Interestingly, both injection routes ameliorated inflammation and liver cirrhosis scores. All mice in treatment groups had reduced inflammation scores and no cirrhosis. In conclusion, transplantation of BM-MSCs via tail or portal veins ameliorates liver cirrhosis in mice. Notably, there were no differences in treatment effects between tail and portal vein administrations. In consideration of safety, we suggest transfusion of bone marrow-derived mesenchymal stem cells via a peripheral vein as a potential method for liver fibrosis treatment.

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