Resveratrol pretreatment enhanced homing of SDF-1α-preconditioned bone marrow-derived mesenchymal stem cells in a rat model of liver cirrhosis

2017 ◽  
Vol 119 (3) ◽  
pp. 2939-2950 ◽  
Author(s):  
Mehrdad Hajinejad ◽  
Parichehr Pasbakhsh ◽  
Ameneh Omidi ◽  
Keywan Mortezaee ◽  
Saied Nekoonam ◽  
...  
Keyword(s):  
Stem Cells ◽  
Bone Marrow ◽  
Mesenchymal Stem Cells ◽  
Liver Cirrhosis ◽  
Rat Model

Bone marrow mesenchymal stem cells can improve the motor function of a Huntington's disease rat model

2011 ◽  
Vol 33 (3) ◽  
pp. 331-337 ◽  
Author(s):  
Yufeng Jiang ◽  
Hailong Lv ◽  
Shanshan Huang ◽  
Huiping Tan ◽  
Yinong Zhang ◽  
...  
Keyword(s):  
Stem Cells ◽  
Bone Marrow ◽  
Mesenchymal Stem Cells ◽  
Huntington's Disease ◽  
Huntington’S Disease ◽  
Motor Function ◽  
Rat Model ◽  
Marrow Mesenchymal Stem Cells

Transplantation of Bone Marrow Mesenchymal Stem Cells (BMSCs) Overexpressing Circular Zinc Finger Protein 609 Alleviates Diabetic Retinopathy

2021 ◽  
Vol 11 (12) ◽  
pp. 2497-2501
Author(s):  
Sheng Chen ◽  
Meiwen Tian ◽  
Shenwen Liu
Keyword(s):  
Stem Cells ◽  
Bone Marrow ◽  
Mesenchymal Stem Cells ◽  
Diabetic Retinopathy ◽  
Rat Model ◽  
Zinc Finger Protein ◽  
Retinal Thickness ◽  
Vitreous Body ◽  
Macular Volume ◽  
Marrow Mesenchymal Stem Cells

Diabetic retinopathy (DR) is a chronic complications and its pathogenesis remains unclear. This study aims to elucidate the underlying mechanism by how bone marrow mesenchymal stem cells (BMSCs) affects DR development in a rat model. A rat model of DR was established and injected with BMSCs overexpressing Cir-ZNF609 and shRNA Cir-ZNF609 to vitreous body followed by analysis of the retinal vascular permeability and macular retinal layers thickness, and the levels of HIF-1α, ICAM-1 and VEGF in rat retina by ELISA and immunohistochemistry. Injection of BMSCs overexpressing Cir-ZNF609 resulted in decreased HIF-1α ICAM-1 and VEGF expression, amelioration of retinal ganglion choriocapillaris injury and reducing ganglion cells. Twelve weeks after treatment, neovascularization took place and fibroblasts appeared with some nucleus disappearing and pigment taking off. Besides, permeability also elevated in the presence of overexpressing Cir-ZNF609 and penetration rate for Evans blue (16.36+3.25, 15.45±3.46 μg/g) was lower than healthy rats (28.66±2.08, 32.24±4.36 μg/g) and controls (26.93±3.03, 33.49±5.02 μg/g) (p < 0.01). Moreover, upregulation of Cir-ZNF609 decreased retinal thickness and macular volume in DR rats (p < 0.05). In conclusion, intravitreal injection of mouse BMSCs overexpressing Cir-ZNF609 alleviates retinal injury and decreases retinal thickness and macular volume, and enhances neovascularization. These evidence provides a novel insight into gene therapy for DR.

Bone Marrow Mesenchymal Stem Cells (BMSCs) Transplantation Ameliorates Joint Severity and Inflammation in Rats with Arthritis

2022 ◽  
Vol 12 (5) ◽  
pp. 1028-1033
Author(s):  
Liangbang Wu ◽  
Zhenhai Hou ◽  
Longbao Zheng ◽  
Zenghui Gu
Keyword(s):  
Stem Cells ◽  
Bone Marrow ◽  
Mesenchymal Stem Cells ◽  
Rat Model ◽  
Inflammatory Cells ◽  
Type Ii Collagen ◽  
Rankl Expression ◽  
Positive Expression ◽  
Marrow Mesenchymal Stem Cells ◽  
Bovine Type

This study analyzed the action of Bone marrow mesenchymal stem cells (BMSCs) transplantation on arthritis rat model. Arthritis rat model was established using bovine type II collagen and CFA. BMSCs phenotype was assessed by flow cytometry and pathological changes was analyzed by H&E staining along with analysis of joint severity by AI score, inflammation by ELISA as well as level of NPY, MMP-2, and MMP-9. The form of passaged BMSCs was spindle shaped with positive expression of CD29 and CD44. The structure of articular cavity in arthritis rats was disordered with infiltration of inflammatory cells which were ameliorated by BMSCs transplantation. In addition, BMSCs treatment also significantly reduced AI value, the level of VEGF, IL-17 and TNF-α as well as decreased RANK/RANKL expression and increased OPG level. In conclusion, BMSCs transplantation ameliorates inflammation and severity in arthritis rats possibly through regulation of RANK/OPG, indicating that it might be used for the treatment of arthritis patients.

Bone Marrow Mesenchymal Stem Cells (BMSCs) Restore Functional Endometrium in the Rat Model for Severe Asherman Syndrome

2018 ◽  
Vol 26 (3) ◽  
pp. 436-444 ◽  
Author(s):  
Lufen Gao ◽  
Zhongwei Huang ◽  
Haiyingjie Lin ◽  
Yuke Tian ◽  
Ping Li ◽  
...  
Keyword(s):  
Stem Cells ◽  
Bone Marrow ◽  
Mesenchymal Stem Cells ◽  
Rat Model ◽  
Marrow Mesenchymal Stem Cells

Bone marrow-derived mesenchymal stem cells ameliorate liver injury in a rat model of sepsis by activating Nrf2 signaling

2018 ◽  
Vol 151 (3) ◽  
pp. 249-262 ◽  
Author(s):  
Sally A. Selim ◽  
Samia A. Abd El-Baset ◽  
Asmaa A. A. Kattaia ◽  
Eman M. Askar ◽  
Eman Abd Elkader
Keyword(s):  
Stem Cells ◽  
Bone Marrow ◽  
Mesenchymal Stem Cells ◽  
Liver Injury ◽  
Rat Model

scholarly journals Author Correction: Repair of bone defects with prefabricated vascularized bone grafts and double-labeled bone marrow-derived mesenchymal stem cells in a rat model

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Xiao-Rui Jiang ◽  
Hui-Ying Yang ◽  
Xin-Xin Zhang ◽  
Guo-Dong Lin ◽  
Yong-Chun Meng ◽  
...  
Keyword(s):  
Stem Cells ◽  
Bone Marrow ◽  
Mesenchymal Stem Cells ◽  
Rat Model ◽  
Bone Grafts ◽  
Bone Defects ◽  
Vascularized Bone

An amendment to this paper has been published and can be accessed via a link at the top of the paper.

Molecular and Cellular Functions Distinguish Superior Therapeutic Efficiency of Bone Marrow CD45 Cells Over Mesenchymal Stem Cells in Liver Cirrhosis

Stem Cells ◽  
2015 ◽  
Vol 34 (1) ◽  
pp. 135-147 ◽  
Author(s):  
Prakash Baligar ◽  
Snehasish Mukherjee ◽  
Veena Kochat ◽  
Archana Rastogi ◽  
Asok Mukhopadhyay
Keyword(s):  
Stem Cells ◽  
Bone Marrow ◽  
Mesenchymal Stem Cells ◽  
Liver Cirrhosis ◽  
Cellular Functions ◽  
Therapeutic Efficiency
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