scholarly journals Multispecies Cohabitation and Future Design

2020 ◽  
Author(s):  
Stanislav Roudavski ◽  
Keyword(s):  
Future Design

Intestinal microbiota balance modulates host susceptibility to infection with enteric pathogenss

2007 ◽  
Vol 30 (4) ◽  
pp. 93
Author(s):  
I Sekirov ◽  
N Tam ◽  
M Robertson ◽  
C Lupp ◽  
B Finlay
Keyword(s):  
Intestinal Microbiota ◽  
Small Animal ◽  
Host Susceptibility ◽  
Morphological Development ◽  
Future Design ◽  
Susceptibility To Infection ◽  
Colonic Microbiota ◽  
Food Borne ◽  
Serovar Typhimurium ◽  
Intestinal Pathogens

Background: During our lifetimes we develop a very complex set of interactions with the multitude of microorganisms colonizing our bodies. In the gastrointestinal system, the microbiota is highly important for morphological development, nutrition, and protection against infectious diseases. The gastrointestinal pathogens, enterohemorrhagic and enteropathogenic Escherichia coli (EHEC and EPEC) and Salmonella enterica serovar Typhimurium (ST) are food-borne pathogens that cause much morbidity and mortality worldwide. Citrobacter rodentium (Cr) is a mouse pathogen that is used in small animal models to mimic EHEC and EPEC infections. Methods: We began to characterize the contribution of intestinal microbiota to the progression of these infections. Two main phyla comprise the majority of mouse intestinal microbiota: Bacteroidetes and Firmicutes. Bacteria from a number of additional phyla are also present in smaller numbers; among them γ-Proteobacteria class, belonging to Proteobacteria phylum, is note-worthy as this class harbours many intestinal pathogens, such as ST and Cr. The mouse intestinal microbiota was perturbed using tetracycline (Tet) and streptomycin (Sm) to increase the proportion of Bacteroidetes in the colonic microbiota, and using vancomycin (Vanc) to create a predominance of Firmicutes. The mice with this perturbed microbiota were infected with ST to investigate the resultant pathology and virulence characteristics, and any additional shifts in microbiota as a result of infection. Results: Treatment of mice with Sm and Vanc was found to decrease the resistance of mice to colonization with ST, while Tet-treated mice exhibited unchanged colonization resistance. Treatment of mice with gradually increasing doses of Sm, which gradually augmented the proportion of CFB bacteria in the microbiota, resulted in progressively increasing colonization of mice by ST, as well as a step-wise increase in the ST-induced typhlitis, associated with higher levels of inflammatory markers IL-6 and KC. The increasing levels of ST colonization following both Sm and Vanc treatment were associated with an increase in the proportion of γ-Proteobacteria in the cecal and colonic microbiota, as well as a decrease in the total bacterial numbers in both organs. Conclusions: It is evident that the intestinal microbiota plays a significant role in the host’s response to infection with enteric pathogens, and its composition and numbers are also affected by the offending bacteria. Elucidation of the details regarding the contribution of the microbiota to infectious disease progression will offer novel targets for the future design of superior prevention and treatment methods.

What do patients want? A qualitative exploration of patients’ needs and expectations regarding online access to their primary care record

2020 ◽  
Vol 70 (suppl 1) ◽  
pp. bjgp20X711245
Author(s):  
Gail Davidge ◽  
Caroline Sanders ◽  
Rebecca Hays ◽  
Rebecca Morris ◽  
Helen Atherton ◽  
...  
Keyword(s):  
Primary Care ◽  
Thematic Analysis ◽  
Support Needs ◽  
Future Design ◽  
Wide Range ◽  
Primary Care Record ◽  
Online Access ◽  
Qualitative Exploration ◽  
Nhs Health Check ◽  
Patients Wishes

BackgroundPrimary care records have traditionally served the needs and demands of clinicians rather than those of the patient. GP contracts in England state practices must promote and offer registered patients online access to their primary care record and research has shown benefits to both patients and clinicians of doing so. Despite this, we know little about patients’ needs and expectations regarding online access.AimTo explore patients’ views about accessing online primary care records and to find out how patients would like to interact with their records and what support they may need.MethodInterviews and focus groups with a sample of 50 patients from a variety of socio-demographic backgrounds who were either; eligible for the NHS Health Check; had multimorbidities or were carers. Thematic analysis of data identified major themes impacting upon patients’ wishes and needs as well as highlighting population-specific issues.ResultsParticipants highlighted a wide range of views about the benefits and drawbacks of accessing their records online. The majority of participants indicated that they would be more likely to access their online primary care record if improvements were made to the design, reliability and functionality of existing online record services. Carers found accessing online records particularly useful.ConclusionConsultation with patients and carers about their experiences of accessing online records; support needs and preferred functions can provide useful insights to inform the future design of online record services.

Increasing the capacity of an extended nutrient removal plant by using different techniques

1998 ◽  
Vol 37 (9) ◽  
pp. 175-183 ◽  
Author(s):  
B. Andersson ◽  
H. Aspegren ◽  
U. Nyberg ◽  
J. la Cour Jansen ◽  
H. Ødegaard
Keyword(s):  
Nitrogen Concentration ◽  
Treatment Plant ◽  
Appropriate Technology ◽  
Secondary Effluent ◽  
Suggested Approach ◽  
Future Design ◽  
Actual Load ◽  
Full Scale Tests ◽  
Plant Capacity ◽  
Treatment Step

A comprehensive investigation which included full scale tests was initiated towards the late 1980:s with the primary aim to find an appropriate technology for the Klagshamn wastewater treatment plant in Malmö, Sweden. The finally selected strategy enabled that a concentration of less than 8 mg N/l could be reached in the secondary effluent without having to extend either the primary or secondary treatment step at the actual load on the plant. In order to comply with a future stringent phosphorus standard however, a tertiary filtration plant has to be built. In future, it has to be anticipated that the load on the plant may be doubled due to the fact that a bridge between Malmö and Copenhagen is being built. As a consequence, it was important to continue the upgrading work by estimating the ultimate plant capacity and to look for measures to increase the capacity if necessary. By optimising the plant operation, it seems possible to reach an effluent nitrogen concentration of less than 12 mg/l at a load corresponding to the future design load. The suggested approach implies that the plant has to be operated on the margin and as a consequence the possibility to include a denitrification step as part of the filtration plant was also investigated. As a result, it was decided to build a separate denitrification step at the same time as the filtration plant was built.

A Design of Educational Game to Prevent Cyber-Bullying among Teenagers and An Analysis of Its Effect (Preprint)

2019 ◽  
Author(s):  
Hyung Yoon
Keyword(s):  
Game Design ◽  
Quantitative Research ◽  
Educational Games ◽  
Educational Game ◽  
Quantitative Research Methods ◽  
Prevention Education ◽  
Future Design ◽  
Sensitive Topics ◽  
Mode Of Development

UNSTRUCTURED This paper is a case study on the design of an educational game for the prevention of cyberbullying and an analysis of its educational effect. I selected a game titled “Angry Daddy,” which was developed based on the request of Korean government authority and analyzed the mode of development of the game and its educational effect. For this research, both qualitative and quantitative research methods were used. Moreover, advice regarding the game design was obtained from many experts belonging to various fields. Based on the analysis of the game design and its educational effect, it was confirmed that the following factors are important to design an educational game meant for the prevention of cyberbullying and to enhance its educational effect: First, cooperation between content experts and game development experts is essential to develop an educational game. Second, it should be verified whether the contents and the format of the game are appropriate by analyzing the play test results of the target audience. Third, it is essential to prepare a manual to guide teachers to apply the game to the field. Fourth, it was confirmed that educating students on sensitive topics like cyberbullying is very effective when educational games that make them feel and experience the outcomes of bullying are utilized. This research is expected to be helpful for future design of educational games and the research and development of the format of cyberbullying prevention education.

WITHWomen: User Centered Approach to the Design and Development of a suite of Intimate Partner Violence Screening and Safety Planning Web-Applications (Preprint)

2020 ◽  
Author(s):  
Patricia O'Campo ◽  
Alisa Velonis ◽  
Pearl Buhariwala ◽  
Janisha Kamalanathan ◽  
Maha Awaiz Hassan
Keyword(s):  
Partner Violence ◽  
Web Applications ◽  
Lessons Learned ◽  
Evidence Based ◽  
Safety Planning ◽  
Future Design ◽  
Mhealth Technology ◽  
The Right ◽  
Safe Access ◽  
Health Applications

BACKGROUND The popularity of mHealth technology has resulted in the development of numerous applications for almost every type of self-improvement or disease management. M- and e-health solutions for increasing awareness about and safety around partner violence is no exception. OBJECTIVE These applications allow women to control access to these resources and provide unlimited, and with the right design features, safe access when these resources are needed. Few applications, however, have been designed in close collaboration with intended users to ensure relevance and effectiveness. METHODS We report here on the design of a pair of evidence-based m- and e-health applications to facilitate early identification of unsafe relationship behaviors and tailored safety planning to reduce harm from violence including the methods by which we collaborated with and sought input from population of intended users. RESULTS The demographic characteristics of those who participated in the various surveys and interviews to inform the development of our screening and safety-decision support app are presented in (Table 2). CONCLUSIONS Finally, we share challenges we faced and lessons learned that might inform future design efforts of m- and e-health evidence-based applications.

Orchestrating Data, Design, and Narrative

2012 ◽  
Vol 2 (2) ◽  
pp. 1-15
Author(s):  
Charles Miller ◽  
Lucas Lecheler ◽  
Bradford Hosack ◽  
Aaron Doering ◽  
Simon Hooper
Keyword(s):  
Online Learning ◽  
Information Visualization ◽  
Essential Element ◽  
Complex Data ◽  
Daily Lives ◽  
Future Design ◽  
Science And Politics ◽  
Interactive Visualizations ◽  
Online Educators ◽  
Data Design

Information visualization involves the visual, and sometimes interactive, presentation and organization of complex data in a clear, compelling representation. Information visualization is an essential element in peoples’ daily lives, especially those in data-driven professions, namely online educators. Although information visualization research and methods are prevalent in the diverse fields of healthcare, statistics, economics, information technology, computer science, and politics, few examples of successful information visualization design or integration exist in online learning. The authors provide a background of information visualization in education, explore a set of potential roles for information visualization in the future design and integration of online learning environments, provide examples of contemporary interactive visualizations in education, and discuss opportunities to move forward with design and research in this emerging area.

An acoustic liner design methodology based on a statistical source model

2021 ◽  
pp. 1475472X2110238
Author(s):  
Douglas M Nark ◽  
Michael G Jones
Keyword(s):  
Design Methodology ◽  
Three Dimensional ◽  
Aircraft Engine ◽  
Flight Test ◽  
Source Model ◽  
Practical Implementation ◽  
Source Information ◽  
Fan Noise ◽  
Future Design ◽  
Acoustic Liner

The attenuation of fan tones remains an important aspect of fan noise reduction for high bypass ratio turbofan engines. However, as fan design considerations have evolved, the simultaneous reduction of broadband fan noise levels has gained interest. Advanced manufacturing techniques have also opened new possibilities for the practical implementation of broadband liner concepts. To effectively address these elements, practical acoustic liner design methodologies must provide the capability to efficiently predict the acoustic benefits of novel liner configurations. This paper describes such a methodology to design and evaluate multiple candidate liner configurations using realistic, three dimensional geometries for which minimal source information is available. The development of the design methodology has been guided by a series of studies culminating in the design and flight test of a low drag, broadband inlet liner. The excellent component and system noise benefits obtained in this test demonstrate the effectiveness of the broadband liner design process. They also illustrate the value of the approach in concurrently evaluating multiple liner designs and their application to various locations within the aircraft engine nacelle. Thus, the design methodology may be utilized with increased confidence to investigate novel liner configurations in future design studies.

scholarly journals Comparative Analysis of Shear Strength Parallel to Fiber of Different Local Bamboo Species in the Philippines

2021 ◽  
Vol 13 (15) ◽  
pp. 8164
Author(s):  
Brian E. Bautista ◽  
Lessandro E. O. Garciano ◽  
Luis F. Lopez
Keyword(s):  
Mechanical Properties ◽  
Shear Strength ◽  
Comparative Analysis ◽  
Strength Properties ◽  
The Philippines ◽  
Bamboo Species ◽  
Test Protocol ◽  
Future Design ◽  
Average Shear Strength ◽  
Bambusa Vulgaris

There are limited published studies related to the mechanical properties of bamboo species in the Philippines. In this study, the shear strength properties of some economically viable bamboo species in the Philippines were properly characterized based on 220 shear test results. The rationales of selecting this mechanical property are the following: (1) Shear strength, parallel to the fiber, has the highest variability among the mechanical properties; and (2) Shear is one of the governing forces on joint connections, and such connections are the points of failure on bamboo structures when subjected to extreme loading conditions. ISO 22157-1 (2017) test protocol for shear was used for all tests. The results showed that Bambusa blumeana has the highest average shear strength, followed by Gigantochloa apus, Dendrocalamus asper, Bambusa philippinensis, and Bambusa vulgaris. However, comparative analysis, using One-way ANOVA, showed that shear strength values among these bamboo species have significant differences statistically. A linear regression model is also established to estimate the shear strength of bamboo from the physical properties. Characteristic shear strength is also determined using ISO 12122-1 (2014) for future design reference.

scholarly journals Concept of an Ontology for Automated Vehicle Behavior in the Context of Human-Centered Research on Automated Driving Styles

Information ◽  
2021 ◽  
Vol 12 (1) ◽  
pp. 21
Author(s):  
Johannes Ossig ◽  
Stephanie Cramer ◽  
Klaus Bengler
Keyword(s):  
Driving Behavior ◽  
Automation System ◽  
Automated Driving ◽  
Driving Style ◽  
Driving Experience ◽  
Automated Vehicle ◽  
Future Design ◽  
Vehicle System ◽  
The Future ◽  
Conceptual Distinction

In the human-centered research on automated driving, it is common practice to describe the vehicle behavior by means of terms and definitions related to non-automated driving. However, some of these definitions are not suitable for this purpose. This paper presents an ontology for automated vehicle behavior which takes into account a large number of existing definitions and previous studies. This ontology is characterized by an applicability for various levels of automated driving and a clear conceptual distinction between characteristics of vehicle occupants, the automation system, and the conventional characteristics of a vehicle. In this context, the terms ‘driveability’, ‘driving behavior’, ‘driving experience’, and especially ‘driving style’, which are commonly associated with non-automated driving, play an important role. In order to clarify the relationships between these terms, the ontology is integrated into a driver-vehicle system. Finally, the ontology developed here is used to derive recommendations for the future design of automated driving styles and in general for further human-centered research on automated driving.

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