scholarly journals Influence of oral administration of HMB to pregnant dams on calbindin expression in the dentate gyrus of the hippocampus during postnatal development in spiny mice offspring

2017 ◽  
Vol 73 (6) ◽  
pp. 341-345
Author(s):  
Karol Rycerz ◽  
Aleksandra Krawczyk ◽  
Jadwiga Jaworska-Adamu ◽  
Radosław Szalak ◽  
Ewa Tomaszewska ◽  
...  
Keyword(s):  
Dentate Gyrus ◽  
Calcium Ion ◽  
Compensation Effect ◽  
Ion Homeostasis ◽  
Age Groups ◽  
Morphological Alterations ◽  
New Born ◽  
Calbindin D28k ◽  
Long Term Consequences

The aim of the study was to investigate the morphology, density and immunostaining intensity of calbindin (CB)-positive neurons of dentate gyrus (DG) in new-born (P0) and 21-day-old (P21) male Acomys cahirinus mice from dams receiving β-hydroxy-β-methylbutyrate (HMB) during pregnancy. Different substances administrated to pregnant dams may affect the calcium ion homeostasis which is crucial for the proper brain development of their offspring. DG with hilus (H) plays an important role in memory and learning processes. Calcium levels in DG are regulated by buffering proteins like calbindin D28k (CB). Experimental dams were orally treated with HMB at a dose of 0.2g/kg b.w. Half of new-born animals were euthanised after birth and the rest after the 21st day of life. The brains were dissected and embedded in paraffin blocks using a routine histological technique. In order to demonstrate CB protein expression an immunohistochemical peroxidase-antiperoxidase reaction was conducted. The results of the study did not reveal important morphological alterations. There were no statistically significant changes in the density of the studied cells either in P0 and P21 animals. However, the authors have demonstrated a statistically significant increase of the average CB-immunostaining intensity in nuclei and cytoplasm in both age groups. It may be a result of a compensation effect to alterations that occurred under the influence of HMB. On the basis of the conducted research, it may be assumed that HMB activity in DG may provide long-term consequences.

scholarly journals Radiation Doses and Risk Assessment during Computed Tomography of the Chest in COVID-19 Patients

2021 ◽  
Author(s):  
Elena Ivanovna Matkevich ◽  
Ivan Vasilievich Ivanov
Keyword(s):  
Radiation Risk ◽  
Age Groups ◽  
Chest Ct ◽  
Radiation Doses ◽  
Diagnostic Center ◽  
Carcinogenic Effects ◽  
Long Term Consequences ◽  
Effective Radiation ◽  
The City

Accounting for the effective dose (ED, mSv) and calculating the radiation risk during CT is necessary to predict the long-term consequences of radiation exposure on the population. We analyzed the results of 1003 CT examinations of the chest in patients with suspected COVID-19 in the city diagnostic center. The average ED and confidence intervals (p ≤ 0.05) for patients with a single CT scan were: children (12–14 years) 2.59 ± 0.19 mSv, adolescents (15–19 years) 3.23 ± 0.17 mSv, adults (20–64 years), 3.43 ± 0.08 mSv, older persons (65 years and older) 3.28 ± 0.19 mSv. The maximum radiation risk values were 31.2*10–5 in women children and 29.3*10–5 in women adolescents, which exceeds the risk values for men in these age groups by 2.3 and 1.9 times, respectively. For the group of adult patients the risk was 11.2*10–5 in men and 17.4*10–5 in women, which is 1.6 times higher than in men. All these risk values are in the range of 10*10–5–100*10–5, which corresponds to the level LOW. For the group of older age patients, the radiation risk was 2.6*10–5, which corresponds to the level of 1*10–5–10*10–5, VERY LOW. Our materials shows in detail the technique to evaluate effective radiation doses for chest CT and calculate the radiation risk of the carcinogenic effects of this exposure.

Barriers to Physical Activity in Adolescents

2015 ◽  
Vol 23 (2) ◽  
pp. 47-59 ◽  
Author(s):  
Nadine Langguth ◽  
Tanja Könen ◽  
Simone Matulis ◽  
Regina Steil ◽  
Caterina Gawrilow ◽  
...  
Keyword(s):  
Physical Activity ◽  
Leisure Activities ◽  
Outcome Expectations ◽  
Multidimensional Approach ◽  
Factor Analyses ◽  
Physical And Mental Health ◽  
Tailored Interventions ◽  
Long Term Consequences ◽  
Age Range

During adolescence, physical activity (PA) decreases with potentially serious, long-term consequences for physical and mental health. Although barriers have been identified as an important PA correlate in adults, research on adolescents’ PA barriers is lacking. Thus reliable, valid scales to measure adolescents’ PA barriers are needed. We present two studies describing a broad range of PA barriers relevant to adolescents with a multidimensional approach. In Study 1, 124 adolescents (age range = 12 – 24 years) reported their most important PA barriers. Two independent coders categorized those barriers. The most frequent PA barriers were incorporated in a multidimensional questionnaire. In Study 2, 598 adolescents (age range = 13 – 21 years) completed this questionnaire and reported their current PA, intention, self-efficacy, and negative outcome expectations. Seven PA barrier dimensions (leisure activities, lack of motivation, screen-based sedentary behavior, depressed mood, physical health, school workload, and preconditions) were confirmed in factor analyses. A multidimensional approach to measuring PA barriers in adolescents is reliable and valid. The current studies provide the basis for developing individually tailored interventions to increase PA in adolescents.

Responding to Immediate and Long-Term Consequences of Terror

2008 ◽  
Author(s):  
Mary Fabri ◽  
Amber Gray ◽  
Jeannette Uwineza
Keyword(s):  
Long Term Consequences

Themes, Diction, and Prosodic Systems in Yoruba Lullabies

2019 ◽  
Vol 12 (1) ◽  
pp. 18-33 ◽  
Author(s):  
Olusanmi Babarinde ◽  
Elizabeth Babarinde
Keyword(s):  
Participant Observation ◽  
Cultural Beliefs ◽  
Survey Method ◽  
World Views ◽  
Scholarly Research ◽  
Long Term Consequences ◽  
Analyse Data ◽  
Descriptive Survey ◽  
Future Learning

Lullabies are essentially sung for their soothing nature but, as this article shows, they have other important functions. One of the most important of these is that lullabies may provide much-needed language stimulation with important long-term consequences for future learning. This paper begins the work of addressing the dearth of scholarly research on lullabies, especially in the Yoruba (Nigeria: Niger-Congo) culture. It looks at the range of themes, dictions, and prosody that are intertwined to reveal Yoruba beliefs and world-views about children, starting with their time in the womb. The study uses a descriptive survey method to analyse data collected through participant observation. It shows that Yoruba lullabies not only offer insights into Yoruba cultural beliefs but also depend greatly on figurative expression and prosodic systems. These rich literary qualities identify lullabies as the earliest sub-genre of children's poetry.

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