scholarly journals A novel peptide of endothelin family, 31 amino-acid length endothelin in patients with acute myocardial infarction

2014 ◽  
Vol 61 (3.4) ◽  
pp. 298-305 ◽  
Author(s):  
Makiko Oka ◽  
Yasuharu Niwa ◽  
Kazuaki Mawatari ◽  
Yoshikazu Hiasa ◽  
Yutaka Nakaya
Keyword(s):  
Myocardial Infarction ◽  
Acute Myocardial Infarction ◽  
Amino Acid ◽  
Amino Acid Length

Streptokinase binds to lactate dehydrogenase subunit-M, which shares an epitope with plasminogen.

1989 ◽  
Vol 35 (1) ◽  
pp. 69-73 ◽  
Author(s):  
S J Podlasek ◽  
R A McPherson
Keyword(s):  
Myocardial Infarction ◽  
Acute Myocardial Infarction ◽  
Amino Acid ◽  
Lactate Dehydrogenase ◽  
Thrombolytic Agent ◽  
High Molecular Mass ◽  
General Mechanism ◽  
Amino Acid Sequence Homology ◽  
Binding Epitope ◽  
Therapeutic Administration

Abstract The bacterial thrombolytic agent streptokinase binds to human, porcine, and chicken lactate dehydrogenase (EC 1.1.1.27; LD) isoenzyme subunit M, but not to the H or C subunits. There is amino acid sequence homology between LD and the streptokinase binding site on plasminogen to account for this interaction that results in the formation of high-molecular-mass complexes in serum that contain LD activity. Binding of highly immunogenic streptokinase with LD may lead to induction of anti-LD autoantibodies, known to occur in some patients after therapeutic administration of streptokinase for treatment of acute myocardial infarction. This interaction may also be a general mechanism for inducing autoimmunity against other proteins that share the streptokinase binding epitope.

An electron microscopic study of the intra-myocardial lesions in cases of acute myocardial infarction

1978 ◽  
Vol 36 (2) ◽  
pp. 484-485
Author(s):  
Masahiro Ono ◽  
Kaoru Aihara ◽  
Gompachi Yajima
Keyword(s):  
Myocardial Infarction ◽  
Acute Myocardial Infarction ◽  
Coronary Vessels ◽  
Vascular Wall ◽  
Vascular Changes ◽  
Electron Microscopic ◽  
Main Trunk ◽  
Mechanical Destruction ◽  
Transmission Electron ◽  
Myocardial Lesions

The pathogenesis of the arteriosclerosis in the acute myocardial infarction is the matter of the extensive survey with the transmission electron microscopy in experimental and clinical materials. In the previous communication,the authors have clarified that the two types of the coronary vascular changes could exist. The first category is the case in which we had failed to observe no occlusive changes of the coronary vessels which eventually form the myocardial infarction. The next category is the case in which occlusive -thrombotic changes are observed in which the myocardial infarction will be taken placed as the final event. The authors incline to designate the former category as the non-occlusive-non thrombotic lesions. The most important findings in both cases are the “mechanical destruction of the vascular wall and imbibition of the serous component” which are most frequently observed at the proximal portion of the coronary main trunk.

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