scholarly journals ISOLATION AND CHARACTERIZATION OF A FLAVONE FROM SUDANESE VITEX DONIANA (SWEET)(VERBENACEAE) AND BIOLOGICAL ACTIVITY OF THE METHANOLIC FRACTION

2016 ◽  
Vol 4 (6) ◽  
pp. 615-624
Author(s):  
AbdelKarim M ◽  
◽  
Salah H ◽  
Sufian A. ◽  
Sayed. A ◽  
...  
2017 ◽  
pp. 313-329
Author(s):  
Yogesh K. Baravalia ◽  
Komal V. Pokar ◽  
Khyati C. Bhojani ◽  
Shailesh B. Gondaliya

2004 ◽  
Vol 52 (1) ◽  
pp. 65-70 ◽  
Author(s):  
Richard A. Anderson ◽  
C. Leigh Broadhurst ◽  
Marilyn M. Polansky ◽  
Walter F. Schmidt ◽  
Alam Khan ◽  
...  

1977 ◽  
Vol 55 (7) ◽  
pp. 747-754 ◽  
Author(s):  
M. R. Sairam ◽  
Choh Hao Li

Procedures have been described for the isolation of highly purified thyrotropin from frozen or acetone-preserved glands or from side fractions of somatotropin isolation and for the separation of its α and β subunits. The products have been characterized by terminal residue analyses, amino acid composition, carbohydrate content, disc electrophoresis, ultracentrifugation, and biological activity.


2020 ◽  
Vol 17 ◽  
Author(s):  
Rama Mohana Reddy Jaggavarapu ◽  
Venkatanarayana Muvvala ◽  
Venkata Reddy.G ◽  
Ravi Kumar Cheedarala

Introduction: The origin, isolation, and characterization of (Z)-isopropyl 7-((1R, 2R, 3R, 5S)-2-((1E, 3Z)-3-fluoro4-phenoxybuta-1, 3-dienyl)-3, 5-dihydroxycyclopentyl) hept-5-enoate, an impurity found in the preparation of an antiglaucoma agent-Tafluprost has been described. Materials and Methods: Further, an enantiospecific synthesis of (Z)-isopropyl 7-((1R, 2R, 3R, 5S)-2-((1E, 3Z)-3-fluoro-4- phenoxybuta-1, 3-dienyl)-3, 5-dihydroxycyclopentyl) hept-5-enoate has been revealed using deoxofluorination as a key transformation of the strategy. Results and Discussions: Moreover, the impurity showing anti-glaucoma properties in docking studies with respect to bimatoprost. Conclusion: The extent of our work towards docking studies, the present impurity molecule showing almost the same biological activity with respect to Tafluprost.


2020 ◽  
Vol 7 (17) ◽  
pp. 239-245
Author(s):  
H. Abubakar ◽  
A. M. Musa ◽  
M. I. Abdullahi ◽  
V. Mzozoyana ◽  
A. J. Yusuf

Tapinanthus globiferus (A. Rich) Tiegh (Loranthacae) is a semi-parasitic plant growing on several plant species such as Vitex doniana. it is used in ethno-medicine for the treatment of fungal infection, itching, hypertension, ulcers, epilepsy, diabetes and cancer. The aim of this study was to isolate bioactive compound(s) from the leaf of T. globiferus. The powdered plant material was extracted with 90% methanol using maceration method and the resulting crude methanol leaf extract was partitioned into n-hexane, chloroform, ethylacetate and n-butanol fractions. The ethylacetate fraction was chromatographed on a silica gel and sephadex LH-20 column which led to the isolation of two flavonoids, and the identity of the compounds was determined on the basis of chemical test and NMR analysis. Based on the 1D and 2D NMR data, the compounds were 2-(3’4’-dihydroxyphenyl)-3,5,7-trihydroxy-4H-chromane-4-one (quercetin) and 2-(2,4-dihydroxyphenyl)-5,7-dihydroxy-3-(3-methylhexyl)-4H-chromen-4-one. This is the first report of isolation of these compounds from T. globiferus growing on Vitex doniana.


2000 ◽  
Vol 31 (2) ◽  
pp. 149-149 ◽  
Author(s):  
T Tozaki ◽  
H Kakoi ◽  
S Mashima ◽  
K Hirota ◽  
T Hasegawa ◽  
...  

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