scholarly journals Antidiabetic effect of Coccinia grandis (L.) Voigt (Cucurbitales: Cucurbitaceae) on streptozotocin induced diabetic rats and its role in regulating carbohydrate metabolizing enzymes

2018 ◽  
Vol 5 (11) ◽  
pp. 683-698
Author(s):  
Meenatchi Packirisamy ◽  
Purushothaman Ayyakkannu ◽  
Maneemegalai Sivaprakasam
Keyword(s):  
Glycosylated Hemoglobin ◽  
Tolerance Test ◽  
Diabetic Rats ◽  
Antidiabetic Activity ◽  
Perennial Herb ◽  
Optimum Dose ◽  
Oral Glucose ◽  
Metabolizing Enzymes ◽  
Coccinia Grandis ◽  
Treatment Of Diabetes

Coccinia grandis (L.) Voigt (Cucurbitales: Cucurbitaceae) is a climbing perennial herb, growing throughout India and it is widely used in the traditional treatment of diabetes. The aim of present study was to evaluate the antidiabetic potential of the mature unripe of Coccinia grandis in streptozotocin (STZ)-induced diabetic rats with special reference to carbohydrate metabolizing enzymes. The optimum dose of Coccinia grandis extract (GCE) was determined by oral glucose tolerance test. The effects of CGE were compared with glibenclamide. Oral administration of Coccinia grandis extract at a concentration of 250 mg/kg body weight once daily to diabetic rats for the period of 30 days resulted in significant reduction in the levels of plasma glucose and glycosylated hemoglobin. Administration of CGE showed a significant increase in the levels of glycolytic enzymes and glycogen content and decrease in the levels of gluconeogenic enzymes in the liver of diabetic treated rats. The anti-hyperglycemic effect of the extract was comparable with glibenclamide, a known hypoglycemic drug. Present findings provide experimental evidence that the fruits of C. grandis have potential antidiabetic activity which might be used as a functional food and safe remedy for the treatment of diabetes and associated complications.

Antihyperglycemic Effects of Tragia plukenetii Ethanolic Extract

2014 ◽  
Vol 7 (2) ◽  
pp. 2436-2440
Author(s):  
Venkatesh Sama ◽  
Rajini T ◽  
Humera Afrooz ◽  
Balaraju P ◽  
B. Madhava Reddy ◽  
...  
Keyword(s):  
Oral Dose ◽  
Ethanolic Extract ◽  
Tolerance Test ◽  
Diabetic Rats ◽  
Antidiabetic Activity ◽  
Oral Glucose ◽  
Alcoholic Extract ◽  
Antihyperglycemic Activity ◽  
Treatment Of Diabetes

Plants represent a major potential source of drugs for treating diabetes. The study of plants having antidiabetic activity may give a new approach in the treatment of diabetes mellitus. Tragia plukenetii is traditionally claimed to be useful in the treatment of diabetes. The present study was intended to evaluate the antihyperglycemic activity of aqueous ethanolic extract on normal fasted, glucose loaded and alloxan induced diabetic rats, at an oral dose of 75, 150 and 300 mg/kg in male Wistar rats. The alcoholic extract has not produced any hypoglycemia in normal fasted rats. The ethanolic extract has displayed a significant dose dependent antihyperglycemic activity in oral glucose tolerance test and in alloxan induced diabetic rats at an oral dose of 150 and 300 mg/kg. The ethanolic extract has effectively scavenged the stable free DPPH radical in-vitro. It is concluded that Tragia plukenetii aerial parts alcoholic extract is effective in controlling blood glucose levels in diabetic rats.

Antidiabetic Effects of Ethanolic Extract of Ficus glomerata (L.) Roots

2020 ◽  
Vol 16 (1) ◽  
pp. 33-41
Author(s):  
Mohini C. Upadhye ◽  
Uday Deokate ◽  
Rohini Pujari ◽  
Vishnu Thakare
Keyword(s):  
Body Weight ◽  
Glucose Tolerance ◽  
Density Lipoprotein ◽  
Ethanolic Extract ◽  
Tolerance Test ◽  
Diabetic Rats ◽  
Antidiabetic Activity ◽  
Control Group ◽  
Oral Glucose ◽  
Ficus Glomerata

Background: Ficus glomerata (F. glomerata) Linn. Family Moraceace is a large tree found all over India including outer Himalayan ranges, Punjab, Chota Nagpur, Bihar, Orissa, West Bengal, Rajasthan, Deccan and also as a common plant in South India. It is planted around the home and temples. It is cultivated throughout the year, distributed in evergreen forests and moist localities. Objective: The Ethanolic Extract of roots of F. Glomerata (EEFG) belonging to the family Moraceace, was investigated for its antidiabetic activity using alloxan induced diabetic rats. Methods: Thirty rats were divided into 5 groups having 6 rats in each group. The alloxan was administered to the rats of all groups except normal control group through intraperitoneal route at a concentration of 140mg/kg body weight. A dose of 100mg/kg and 200 mg/kg body weight of EEFG was administered to alloxan induced diabetic rats. The administration of the extract was lasted for 11 days. Effectiveness of the extract on glucose, cholesterol, triglycerides, and high density lipoprotein and protein concentrations was analyzed. Results: Significant (p<0.05) reduction in the levels of glucose, cholesterol, triglyceride of the diabetic rats was observed after treatment with ethanolic extract. After subjecting to oral glucose tolerance test EEFG also showed significant improvement in glucose tolerance. Conclusion: F. glomerata root ethanolic extract showed that it possesses antidiabetic effect and can be found useful for the management of diabetes mellitus.

scholarly journals Evaluation of Antihyperglycemic potential of homeopathic medicines Insulinum, Pancreatinum and Uranium nitricum in Streptozotocin Induced diabetic Rats.

2021 ◽  
Vol 19 (3) ◽  
pp. 02-17
Author(s):  
Aditya Dilipkumar Patil ◽  
Charusheela Dilipkumar Patil ◽  
Dilipkumar Kondiba Patil
Keyword(s):  
Diabetes Mellitus ◽  
Glucose Tolerance Test ◽  
Fasting Blood Glucose ◽  
Hdl Cholesterol ◽  
Holistic Approach ◽  
Tolerance Test ◽  
Serum Glucose ◽  
Diabetic Rats ◽  
Oral Glucose ◽  
Treatment Of Diabetes

INTRODUCTION – Diabetes Mellitus is an emerging endocrine and metabolic disorder which has affected millions of people globally. Homeopathy a science of ultra-molecular doses with a holistic approach is used in treatment of Diabetes Mellitus. Homeopathic medicines are prepared from plant, mineral, sarcodes, nosodes and animal parts. Insulinum, Pancreatinum and Uranium nitricum is used in homeopathy for treatment of Diabetes Mellitus. However no any preclinical studies have been investigated for the anti-diabetic effect and its safety. METHODS – Homeopathic medicines Insulinum, Pancreatinum and Uranium nitricum in 6C (1012) dilution factor were used to examine antihyperglycemic effects in streptozotocin induced diabetic rats. After 28 days treatment bodyweight, Hematology, Biochemistry (serum glucose, urea, creatinine, SGPT, SGOT, ALP, Triglyceride and HDL-cholesterol), Oral Glucose Tolerance Test, HbA1C with histopathology of (Liver, Kidney, Pancreas) was measured. RESULTS – After Streptozotocin induction, the animals have shown significant increase in the fasting blood glucose level (p

AN INVESTIGATION ON ANTIDIABETIC AND ANTIOXIDANT ACTIVITY OF EXTRACT OF LEAVES OF AMARANTHUS POLYGAMUS IN STREPTOZOTOCIN INDUCED DIABETIC RATS

INDIAN DRUGS ◽  
2018 ◽  
Vol 55 (10) ◽  
pp. 49-55
Author(s):  
M. P Singh ◽  
◽  
S. T Shukla ◽  
A. Pateriya
Keyword(s):  
Antioxidant Activity ◽  
Glucose Tolerance Test ◽  
Tolerance Test ◽  
Serum Glucose ◽  
Diabetic Rats ◽  
Antidiabetic Activity ◽  
Oral Glucose ◽  
Oral Glucose Tolerance ◽  
Dpph Assay ◽  
Slight Elevation

The aim of the present study was to assess the antihyperglycemic and antioxidant activites of the methanol extracts of Amaranthus polygamus (MEAP). Indian folklore suggests the plant as good liver tonic and is recommended as vegetable for diabetic and anemic patients. MEAP was evaluated for antidiabetic activity by using streptozotocin (STZ)- induced diabetic rats. The administration of MEAP and glibenclamide (GLB) to diabetic rats for 21 days showed marked fall in serum glucose (SG) levels compared to basal values i.e. at 1st day. MEAP (400 mg/kg) and GLB (0.5 mg/kg) showed significant reduction(P<0.0001) in SG level (37.2% and 52.9%, respectively). MEAP (400 mg/kg) and GLB showed significant improvement in oral glucose tolerance test (OGTT) and slight elevation in SG level, but after 60 min it showed marked downfall over the period of 120 min in comparison with 30 min. MEAP also possesses some antioxidant activity IC50 = 47.80 μg/ml in DPPH assay.

scholarly journals Protective Effect of Free and Bound Polyphenol Extracts from Ginger (Zingiber officinaleRoscoe) on the Hepatic Antioxidant and Some Carbohydrate Metabolizing Enzymes of Streptozotocin-Induced Diabetic Rats

2013 ◽  
Vol 2013 ◽  
pp. 1-7 ◽  
Author(s):  
Mutiu Idowu Kazeem ◽  
Musbau Adewunmi Akanji ◽  
Musa Toyin Yakubu ◽  
Anofi Omotayo Tom Ashafa
Keyword(s):  
Body Weight ◽  
Antioxidant Enzymes ◽  
Liver Function ◽  
Fasting Blood Glucose ◽  
Zingiber Officinale ◽  
Tolerance Test ◽  
Diabetic Rats ◽  
Oral Glucose ◽  
Metabolizing Enzymes ◽  
Antioxidant Enzymes Activities

This study investigated the hepatoprotective effects of polyphenols fromZingiber officinaleon streptozotocin-induced diabetic rats by assessing liver antioxidant enzymes, carbohydrate-metabolizing enzymes and liver function indices. Initial oral glucose tolerance test was conducted using 125 mg/kg, 250 mg/kg, and 500 mg/kg body weight of both free and bound polyphenols fromZ. officinale. 28 day daily oral administration of 500 mg/kg body weight of free and bound polyphenols fromZ. officinaleto streptozotocin-induced (50 mg/kg) diabetic rats significantly reduced (P<0.05) the fasting blood glucose compared to control groups. There was significant increase (P<0.05) in the antioxidant enzymes activities in the animals treated with both polyphenols. Similarly, the polyphenols normalised the activities of some carbohydrate metabolic enzymes (hexokinase and phosphofructokinase) in the liver of the rats treated with it and significantly reduced (P<0.05) the activities of liver function enzymes. The results from the present study have shown that both free and bound polyphenols fromZ. officinaleespecially the free polyphenol could ameliorate liver disorders caused by diabetes mellitus in rats. This further validates the use of this species as medicinal herb and spice by the larger population of Nigerians.

scholarly journals Mechanisms of Antidiabetic Activity of Methanolic Extract of Punica granatum Leaves in Nicotinamide/Streptozotocin-Induced Type 2 Diabetes in Rats

Plants ◽  
2020 ◽  
Vol 9 (11) ◽  
pp. 1609
Author(s):  
Shinu Pottathil ◽  
Parminder Nain ◽  
Mohamed A. Morsy ◽  
Jaspreet Kaur ◽  
Bandar E. Al-Dhubiab ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Methanolic Extract ◽  
Density Lipoprotein ◽  
Punica Granatum ◽  
Tolerance Test ◽  
Daily Basis ◽  
Diabetic Rats ◽  
Antidiabetic Activity ◽  
Oral Glucose

The current study aimed to establish the mechanisms of antidiabetic activity of methanolic extract of Punica granatum leaves (MEPGL) in nicotinamide/streptozotocin-induced type 2 diabetes in rats. Phytochemical screening, HPLC analysis, and acute toxicity study of MEPGL were carried out. Various concentrations of MEPGL (100, 200, 400, and 600 mg/kg) were administered orally to diabetic rats for 45 days on a daily basis. The antidiabetic effect of MEPGL was examined by measuring blood glucose, plasma insulin, and glycated hemoglobin (HbA1c) levels, as well as with an oral glucose tolerance test. The antioxidant effect of MEPGL was determined by analyzing hepatic and renal antioxidant markers, namely superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), reduced glutathione (GSH), and lipid peroxidation. The other biochemical markers alanine transaminase (ALT), aspartate transaminase (AST), alkaline phosphatase (ALP), urea, and creatinine, as well as total cholesterol, triglycerides, and high-density lipoprotein (HDL) were also studied. Type 2 diabetes significantly altered these parameters, while oral administration of the MEPGL significantly ameliorated them. Moreover, the pancreatic histopathological changes were attenuated with MEPGL treatment. In a nutshell, oral MEPGL administration in diabetic rats showed antidiabetic activity due to its antioxidant activity, most probably due to the gallic acid, ellagic acid, and apigenin found in MEPGL.

Antidiabetic Effect of Hydroalcoholic Extract of Barringtonia acutangula Linn. Root on Streptozotocin-induced Diabetic Rats

2010 ◽  
Vol 3 (3) ◽  
pp. 1158-1164
Author(s):  
Nilesh P Babre ◽  
Subal Debnath ◽  
Manjunath S Y ◽  
Malla Reddy V ◽  
Murlidharan Panda ◽  
...  
Keyword(s):  
Ethanolic Extract ◽  
Tolerance Test ◽  
Diabetic Rats ◽  
Antidiabetic Activity ◽  
Oral Glucose ◽  
Oral Toxicity ◽  
Toxic Reaction ◽  
Glucose Levels ◽  
Blood Glucose Levels ◽  
Pharmacological Screening

 Phytochemicals such as alkaloids, glycosides, phenols, tannins, carbohydrates and saponins have been known to possess antidiabetic activity. The crude aqueous ethanolic extract from roots of Barringtonia acutangula Linn (EBA) were prepared, subjected to preliminary photochemical analyses to know the presence of alkaloids, flavonoids, tannins and saponins, which are proved to act as potent antioxidants indicating the possibility of the antidiabetic nature. The crude aqueous extract at a dose of 2000 mg/kg bw/p.o were used for studying acute oral toxicity as per OECD 423 guideline. Neither lethality was observed nor any profound toxic reaction, indicating 2000 mg/kg /p.o of aqueous EBA to be safe for further studies. Thus the pharmacological screening was done with two doses, aqueous EBA 250 and 500 mg/kg b.w/p.o. In normal fasted rats, aqueous EBA treatment at both the dose levels were found to reduce the blood glucose levels, significantly. The aqueous EBA also showed a significant improvement in oral glucose tolerance test. 

scholarly journals Comparative Evaluation of the Antidiabetic Effects of Different Parts ofCassia fistulaLinn, a Southeast Asian Plant

2013 ◽  
Vol 2013 ◽  
pp. 1-10 ◽  
Author(s):  
John Wilking Einstein ◽  
Mustafa Mohd Rais ◽  
Mustafa Ali Mohd
Keyword(s):  
Glucose Uptake ◽  
Methanolic Extract ◽  
Glycosylated Hemoglobin ◽  
Tolerance Test ◽  
Serum Marker ◽  
Diabetic Rats ◽  
Oral Glucose ◽  
Sprague Dawley ◽  
Methanolic Extracts ◽  
Isolated Rat

The hypoglycemic effect of the methanolic and aqueous extracts of whole parts ofCassia fistulain both normoglycemic and streptozotocin-nictotinamide induced Type 2 diabetic rats were investigated. Acute toxicity, oral glucose tolerance test and glucose uptake in isolated rat hemidiaphragm were performed in normal rats. Diabetes was induced in Sprague Dawley rats by the administration of streptozotocin-nictotinamide (50, 110 mg/kg b.w., resp.) intraperitoneally. Different extracts ofCassiawas administered to diabetic rats at 250 and 500 mg/kg doses for 21 days. Biochemical parameters like blood glucose, insulin, glycosylated hemoglobin, lipid profile, and serum marker enzymes were determined. The methanolic extract of the bark and leaves were show more effective in causing hypoglycemia in normoglycemic rats. Diabetic rats showed increased levels of glycosylated hemoglobin, reduced levels of plasma insulin, were significantly reverted to near normal after oral administration of the bark and leaf methanolic extracts. Glucose uptake studies in isolated rat hemidiaphragm have shown enhanced peripheral utilization of glucose. Chronic treatment ofCassiaremarkably restored the normal status of the histopathological changes observed in the selected tissues. Dose dependent anti-diabetic effects with the cohorts receiving the methanolic extract of bark followed by leaves ofCassiawas revealed.

Antidiabetic Effect of Aqueous Corrigiola telephiifolia in Streptozotocin- Induced Diabetic Rats

2020 ◽  
Vol 10 (1) ◽  
pp. 61-68 ◽  
Author(s):  
Morad Hebi ◽  
Mohamed Eddouks
Keyword(s):  
Blood Glucose ◽  
Glucose Tolerance Test ◽  
Tolerance Test ◽  
Diabetic Rats ◽  
Oral Glucose ◽  
Oral Glucose Tolerance ◽  
Phytochemical Screening ◽  
Antidiabetic Effect ◽  
Glucose Levels ◽  
Blood Glucose Levels

Background: Corrigiola telephiifolia Pourr, is a perennial species, woody distributed throughout the north of Africa. This plant is used in traditional Mediterranean preparations and has many traditional uses especially treatment of diabetes. Aim/Methods: The current research was carried out to evaluate the antidiabetic effect of Aerial Parts of Aqueous Extract (APAE) of Corrigiola telephiifolia (C. telephiifolia) on both normal and streptozotocin (STZ)-induced diabetic rats treated at a dose of 5 mg/kg for fifteen days. Additionally, the histopathological changes in the liver, morphometric analysis, Oral Glucose Tolerance Test (OGTT) in normal rats and preliminary phytochemical screening for various components were realized. Results: Single oral administration of the APAE of C. telephiifolia (5mg/kg) showed no significant change in glycaemia of normal and STZ-induced diabetic rats. In contrast, repeated oral administration of C. telephiifolia reduced blood glucose levels from 4.11 ± 0.10 mmol/L to 3.16 ± 0.16 mmol/L (p<0.01) 15 days after administration in normal rats. Furthermore, blood glucose levels decreased from 17.84 ± 1.75mmol/L to 1.93 ± 0.33 mmol/L (p<0.0001) in STZ diabetic rats after fifteen days of treatment. According to the oral glucose tolerance test, C. telephiifolia (5 mg/kg) was shown to prevent significantly the increase in blood glucose levels in normal treated rats 30 min after glucose administration when compared to the control group. Also, the liver architecture of diabetic rats treated by C. telephiifolia was improved when compared with the liver architecture of untreated diabetic rats. Concerning the preliminary phytochemical screening of C. telephiifolia, several compounds have been found such as polyphenols, flavonoids, saponins, mucilage and terpenoids. Conclusion: The results show that the aqueous extract of C. telephiifolia possesses significant antihyperglycemic activity.

scholarly journals Pharmacological potential of methanol extract of Anacardium occidentale stem bark on alloxan-induced diabetic rats

2018 ◽  
Vol 5 (7) ◽  
pp. 2440-2454
Author(s):  
D. A. Omoboyowa ◽  
F. O. Afolabi ◽  
T. C. Aribigbola
Keyword(s):  
Blood Glucose ◽  
Glucose Tolerance ◽  
Glucose Tolerance Test ◽  
Methanol Extract ◽  
Stem Bark ◽  
Tolerance Test ◽  
Diabetic Rats ◽  
Oral Glucose ◽  
Oral Glucose Tolerance ◽  
Β Cells

Background: The anti-hyperglycemic potential of methanol stem bark extract of Anacardium occidentale (MSBEAO) was investigated using an alloxan-induced diabetic rat model. Alloxan administration induces the generation of free radicals which can affect antioxidant status resulting in the disruption of the β-cells of the pancreas. Therefore, this study examines the antioxidant potential of the plant extract and the ameliorating effect on the pancreas of alloxan-induced diabetic rats. Methods: Diabetes was induced by intraperitoneal injection of 150 mg/kg body weight of alloxan monohydrate. MSBEAO, at a concentration of 100 or 200 mg/kg b.w. was orally administered to alloxan-induced diabetic rats and normal rats. The hypoglycemic effect, oral glucose tolerance test, and biochemical assay of alloxan-induced diabetic rats were assayed using standard procedures. Results: Preliminary phytochemical screening of the extract revealed the presence of alkaloids, tannins, saponins, terpenoids, carbohydrates, and phenols at moderate concentrations. The lethality dose (LD50) of the plant extract was found to be equal to or less than 5000 mg/kg b.w. The hypoglycemic effect of the extract on the non-diabetic rats revealed a significant (p<0.05) decrease in the blood glucose concentration of animals administered with 1 g/kg b.w. of the extract, compared to normal control rats administered with normal saline. In the oral glucose tolerance test, the methanol extract exerted the highest response, similar to glibenclamide after 15 and 30 minutes of administration, compared to the control rats. The methanol extract yielded the highest blood glucose lowering effects after 9 days of treatment (p<0.05), compared to diabetic rats administered with normal saline and 0.3 mg/kg b.w. of glibenclamide. Administration of the extract at 200 mg/kg b.w. showed improved pancreas architecture and regeneration of the β-cells, compared with the pancreas of animals in the other groups. Conclusion: The results of this study suggest that MSBEAO is a potentially effective agent for the management of diabetes which might result from the antioxidant-generating capacity of the stem bark.

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